149 research outputs found
Measurement of insulin-mediated glucose uptake: Direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp
No full textBackground: Two direct measurements of peripheral insulin sensitivity are the M value derived from the euglycemic, hyperinsulinemic clamp (EC) and the steady-state plasma glucose (SSPG) concentration derived from the insulin suppression test (IST). Prior work suggests that these measures are highly correlated, but the agreement between them is unknown. To determine the agreement between SSPG and M and to develop transformation equations to convert SSPG to M and vice versa, we directly compared these two measurements in the same individuals. Methods: A total of 15 nondiabetic subjects (9 women and 6 men) underwent both an EC and a modified version of the IST within a median interval of 5 days. We performed standard correlation metrics of the two measures and developed transformation regression equations for the two measures. Results: The mean ± SD age of the subjects was 57 ± 7 years and body mass index, 27.7 ± 3.9 kg/m2. The median (interquartile range) SSPG concentration was 6.7 (5.1, 9.8) mmol/L and M value, 49.6 (28.9, 64.2) μmol/min/kg-LBM. There was a highly significant correlation between SSPG and M (r = - 0.87, P < 0.001). The relationship was best fit by regression models with exponential/logarithmic functions (R2 = 0.85). Bland-Altman plots demonstrated an excellent agreement between these measures of insulin action. Conclusion: The SSPG and M are highly related measures of insulin sensitivity and the results provide the means to directly compare the two measurements. © 2013 Elsevier Inc
Why Syndrome X? From Harold Himsworth to the Insulin Resistance Syndrome
No full textAlthough the concept of Syndrome X was introduced in the Banting Medal address of 1988 (Reaven, 1988), the notion that led to its genesis had started approximately 50 years earlier. In this short history, an attempt will be made to trace the two paths of scientific discovery that were formally merged in New Orleans in 1988 to form the scientific foundation of Syndrome X. In addition, the developments in the last 16 years that have led from the notion of Syndrome X to the broader concept of an Insulin Resistance Syndrome (IRS) will be briefly summarized
Beneficial Effect of Moderate Weight Loss in Older Patients with Non‐Insulin‐dependent Diabetes Mellitus Poorly Controlled with Insulin
No full textInsulin-Stimulated Glucose Disposal in Patients with Type I (IDDM) and Type II (NIDDM) Diabetes Mellitus
No full textRole of Abnormalities of Carbohydrate and Lipoprotein Metabolism in the Pathogenesis and Clinical Course of Hypertension
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