242 research outputs found
[Stammbuch Johann Daniel Halder] / Joannes Daniel Halder
No full text[STAMMBUCH JOHANN DANIEL HALDER] / JOANNES DANIEL HALDER
[Stammbuch Johann Daniel Halder] / Joannes Daniel Halder ( - )
Cover ( - )
Beschreibung, Eintrag von Christian Ulrich Wagner II., Blatt [I]r ([I]r)
Besitzvermerk: Halder, Johann Daniel; Blatt [II]r-[III]r ([I]v-[II]r)
Register über sämtliche hierinn befindliche Namen, Blatt [III]v, [IV]v ([III]v-1)
Cabrera, Juan Simon Henrique de; Blatt 1 ([III]v-1)
Schad, Theodor August; Blatt 2 ( - )
Baldinger, Alexander; Blatt 3 (3v-4r)
Krafft von Dellmensingen, Raymund; Blatt 7 (6v-7r)
Wucherer, Caspar; Blatt 11 (11r)
Guther, David; Blatt 12 (11v-12r)
Stromeyer, Friedrich; Blatt 13 (12v-13r)
Struve, Burkhard Gotthelf; Blatt 14 (13v-14r)
Dietmar, Johann Wilhelm; Blatt 15 (14v-15r)
Wagner, Christoph; Blatt 16 (15v-16r)
Beck, Michael; Blatt 17 (16v-17r)
Roth, Eberhard Rudolph; Blatt 18 (17v-18r)
Ringmacher, Daniel; Blatt 19r (18v-19r)
Frick, Johann; Blatt 19v (19v-20r)
Weyhenmeyer, Elias; Blatt 20r (19v-20r)
Baier, Johann; Blatt 20v (20v-21r)
Dietz, Johann Georg; Blatt 21 (20v-21r)
Elwerth, Johann Philipp; Blatt 22 (21v-22r)
Beger, Johann Georg; Blatt 23 (22v-23r)
Cadisch, Moritz; Blatt 25 (24v-25r)
Fritz, Sigmund; Blatt 28 (27v-28r)
Welser, Marx Christoph von; Blatt 40 (39v-40r)
Otto, Sebastian; Blatt 44 (43v-44r)
Gockel, Balthasar; Blatt 45r (44v-45r)
Veiel, Elias Jacob; Blatt 45v (45v-46r)
Algoewer, David; Blatt 46 (45v-46r)
Herttenstein, Johann Friedrich; Blatt 47 (46v-47r)
Usenbenz, Johann Andreas; Blatt 48 (47v-48r)
Holl, Johann; Blatt 49 (48v-49r)
Frick, Albrecht; Blatt 50 (49v-50r)
Gerhard, Sebastian Konrad; Blatt 51 (50v-51r)
Frick, Septimus Helvig; Blatt 52 (51v-52r)
Stölzlin, Timotheus; Blatt 53r (52v-53r)
Stölzlin, David; Blatt 53v (53v-54r)
Halder, Jakob Ulrich; Blatt 54v (54v-55r)
Philon; Blatt 55 (54v-55r)
Burmeister, Johann Christian; Blatt 56 (55v-56r)
Hocheisen, Eberhard; Blatt 59 (58v-59r)
Scheifelen, Johann Sigismund; Blatt 60 (59v-60r)
Andler, Friedrich Isaak; Blatt 62r (61v-62r)
Haupt, Johann Georg; Blatt 62v (62v-63r)
Hoser, Paul Burckhard; Blatt 63r (62v-63r)
Dinckel, Balthasar Friedrich; Blatt 63v (63v-64r)
Unbekannt, Blatt 64r (63v-64r)
Keßler, Georg Heinrich; Blatt 64v (64v-65r)
Rau, David Wilhelm; Blatt 65r (64v-65r)
Heckel, Christoph Benjamin; Blatt 65v (65v-66r
Christologie als Philosophie: Georg Wilhelm Friedrich Hegel
No full textChristologie als Philosophie : Georg Wilhelm Friedrich Hegel. - In: Auf der Suche nach dem verborgenen Gott / hrsg. von Alois Halder ... - Düsseldorf : Patmos-Verl., 1987. - S. 127-145. - (Beiträge zur Theologie und Religionswissenschaft : Experiment Religionsphilosophie ; 1
Marc Halder: Der Titokult. Charismatische Herrschaft im sozialistischen Jugoslawien [review in German]
No full textMarc Halder: Der Titokult. Charismatische Herrschaft im sozialistischen Jugoslawien [The Tito Cult. Charismatic Rule in Socialist Yugoslavia], München, Oldenbourg, 2013. 367 pp. (Südosteuropäische Arbeiten. 149). – ISBN 978-3-486-72289-5.Universität TrierDeutschlan
"... im Schlamme des Lebens die wahre Würde bewahren": Freiheit, Gott und Natur im Werk Georg Büchners
No full text"... im Schlamme des Lebens die wahre Würde bewahren" : Freiheit, Gott u. Natur im Werk Georg Büchners. - In: Spuren der Erlösung / hrsg. von Alois Halder ... - Düsseldorf : Patmos-Verl., 1986. - S. 175-182. - (Beiträge zur Theologie und Religionswissenschaft : Experiment Religionsphilosophie ; 2
Transduction of mechanical and cytoskeletal cues by YAP and TAZ.
No full textThe physical and mechanical properties of the cellular microenvironment regulate cell shape and can strongly influence cell fate. How mechanical cues are sensed and transduced to regulate gene expression has long remained elusive. Recently, cues from the extracellular matrix, cell adhesion sites, cell shape and the actomyosin cytoskeleton were found to converge on the regulation of the downstream effectors of the Hippo pathway YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) in vertebrates and Yorkie in flies. This convergence may explain how mechanical signals can direct normal and pathological cell behaviour
Dynamic Super Round Based Distributed Task Scheduling for UAV Networks
No full textNetworks of Unmanned Aerial Vehicles (UAVs) are emerging in many application domains, e.g., military surveillance. To perform collaborative tasks, the involved UAVs exchange several types of information, e.g., sensor data and commands. The major question here is how to schedule the tasks under dynamic traffic flows to provide network services. Existing solutions use the Round-Robin Strategy (RRS), where the tasks are scheduled statistically by dividing the time into fixed-length rounds. However, the RRS wastes significant network and device resources due to task scheduling in each round. This paper proposes DROVE – a novel clustering approach that allows the UAVs for dynamic task scheduling. However, determining the task scheduling is crucial, as it significantly affects several network parameters, e.g., throughput. Therefore, we devise the problem of distributed task scheduling under dynamic traffic flow scenarios to optimize the throughput. We propose a clustering task scheduling algorithm to serve dynamic traffic flows. Particularly, we integrate the dynamic traffic flows into the Lyapunov drift analysis framework, and determine the throughput optimality of our proposed scheduling algorithm. We perform extensive simulations to validate the effectiveness of DROVE. The results show that DROVE outperforms the state-of-the-art solutions in terms of energy consumption, clustering overhead, throughput, end-to-end delay, flow success rate and packet drop rate. </p
Modulatie van de Hippo Signaalweg en Orgaangroei door RNA-bindende Proteïnen
No full textThe Hippo pathway is an important regulator of animal organ growth and regeneration. The Hippo pathway effector Yorkie (Yki) in flies and YAP/TAZ in humans is a transcriptional co-activator that drives the expression of genes needed for cell proliferation and survival. Deregulation of the Hippo pathway leads to growth defects and tumorigenesis. Although the core Hippo pathway components have been identified and characterized, our current knowledge cannot fully explain how YAP/TAZ/Yki activity is regulated.
In an effort to identify new regulators of Yki, a genetic modifier screen has been performed in Drosophila. In this screen, an hnRNP (heterogeneous nuclear Ribonucleoprotein) Hrb27C has been identified as a positive regulator of Yki activity. Hrb27C turned out to be required for Yki target gene expression and it is likely to intersect with the Hippo pathway upstream of Yki. Additional experiments identified Hrb27C interacting proteins Glorund (Glo), Halfpint (Hfp) and Squid (Sqd) as new modulators of Yki activity. Interestingly, the loss of Glo, Hfp or Sqd had an opposite effect to that of Hrb27C on Yki activity and tissue size. The loss of Hfp showed the most striking phenotype: prominent overgrowth accompanied by a strong induction of Yki activity reporters. Our data suggest that Yki is absolutely required for the loss of Hfp to induce overgrowth and that Yki-induced overgrowth can be enhanced by the loss of Hfp. Hfp is most likely to intersect with the Hippo pathway downstream of Yki.
The results presented in this work suggest a novel link between the Hippo pathway and a large group of proteins commonly referred to as RNA binding factors. Although the exact molecular mechanism has not been identified, these data provide sufficient evidence to conclude that RNA binding proteins are important regulators of the Hippo pathway.status: Publishe
De Hippo-pathway-effectoren YAP en TAZ induceren celcompetitie om levertumoren door autofagie te elimineren
No full textDespite progress in cancer therapies, there are still no effective therapies for several cancers, like liver cancers. Excitingly, my host laboratory recently made an astonishing discovery: using a mouse model for liver cancer, they discovered that genetic stimulation of regeneration by activating the transcriptional co-activator YAP in normal hepatocytes caused tumor cell death and dramatic tumor regression. Therefore, stimulating regeneration in normal cells around tumors initiated a healing process that not only replenished hepatocytes but also caused the elimination of tumor cells. These experiments thus identify a completely novel approach for cancer therapy that we call 'Regenerative Cancer Therapy'. In my project I propose investigate the molecular mechanisms that trigger tumor elimination and develop gene therapy vehicles to activate this anti-tumor process. Given the striking anti‐tumor effect of YAP‐activated hepatocytes, my projects have the potential to provide groundbreaking new insights into a completely novel strategy for cancer therapy.status: Publishe
De rol van de Hippo signaalcascade in leverregeneratie
No full textAccording to the current dogma, the Hippo pathway is a major regulator of organ growth and regeneration. In this model, Hippo pathway effectors YAP and TAZ directly drive cell proliferation during organ growth and regeneration by promoting the expression of target genes involved in cell proliferation. This idea is largely based on results from gain-of-function experiments, which showed that artificial activation of YAP/TAZ is sufficient to trigger ectopic cell proliferation and dramatic overgrowth in many organs including the liver. Notably, however, tissue-specific deletion of Yap and Taz was inconsequential for cell proliferation during developmental liver growth. Similarly, the role of YAP and TAZ in regenerative growth is unclear, and many questions remain until this day.
We and others found that YAP is transiently activated in hepatocytes in response to liver injury. In addition, loss of Yap/Taz in the regenerating liver resulted in regeneration defects. These observations, in combination with the massive proliferative reaction in gain-of-function studies, led to the assumption that YAP/TAZ are required to drive hepatocyte proliferation during regeneration. However, we provide evidence that YAP and TAZ are not essential in regenerating hepatocytes. Instead, we show that impaired liver regeneration is a consequence of Yap/Taz knockout in biliary epithelial cells (BECs), where they play an essential role in development and maintenance.
Since the used knockout model causes gene deletion simultaneously in embryonic hepatocytes and BECs, we aimed to distinguish YAP/TAZ functions in hepatocytes from their functions in BECs using knockout models separately targeting each of these cell types. An in-depth characterization of several BEC-specific knockout mouse models was first performed to choose the most appropriate model. Surprisingly, regenerative defects were observed in BEC-specific Yap/Taz knockout mice, but not in hepatocyte-specific knockouts. The defects appear to be secondary effects of bile duct disruption and cholestasis, which arises as a consequence of Yap/Taz deletion in BECs. Our data suggests that cholestasis impairs the recruitment and activation of macrophages through PXR signaling, thereby delaying the clearance of necrotic cell corpses after toxic injury. The presence or absence of YAP/TAZ in hepatocytes does not affect this regeneration process.
In conclusion, we did not observe a regeneration-specific function for YAP/TAZ in the liver after toxic injury, but instead uncovered an important role for BEC maintenance which, when lost, has far-reaching consequences on homeostasis and regeneration in the whole organ. Since the generally accepted hypothesis for YAP/TAZ as master regulators of growth was largely based on incorrectly interpreted phenotypes in the liver, endogenous YAP/TAZ functions might differ between organs and should be reassessed in a tissue- and cell type-specific manner. Indeed, our study reveals highly surprising results that will force a fundamental change in how we think about the function of the Hippo pathway, not only in regeneration, but in growth control in general.status: Publishe
Dnp Jakobus Spengler 1580 : Consul Reipubl. Sangallensis
No full textPorträt des Bügermeisters Jakob Spengler mit Halskrause und Pelzumhang in einem profilierten Rahmen mit FamilienwappenG. L. Hartman del. ; Laur. Halder sc.Gemäss dem gedruckten Verweis "ex. Bib. Sangal" unterhalb des Porträts stammt das Blatt aus der "Bibilia Sangallensis
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