230 research outputs found
Is Interchangeability Possible? Understanding and Evaluating the Evidence Base-Implications for Quality and Safety
No full textGeno Merli, a board-certified specialist in internal medicine and physical medicine and rehabilitation, is Director of the Jefferson Center for Vascular Disease at Jefferson Medical College and Senior Vice President and Chief Medical Officer at Thomas Jefferson University Hospital.
Dr. Merli received his medical degree from Jefferson Medical College and completed his residency in rehabilitation medicine and internal medicine at Thomas Jefferson University Hospital. Dr. Merli is a nationally recognized expert in the areas of prophylaxis for and management of deep-vein thrombosis and pulmonary embolism (DVT/PE), as well as for the medical consultation of surgical patients. His research interests have focused on prophylaxis for DVT/PE and the management of DVT in acute spinal cord injury, total joint replacement, trauma, and high-risk cancer patients.
Former editor-in-chief of Internal Medicine, Dr. Merli currently serves on the editorial board of Patient Care, Journal of the Society of Hospital Medicine, and The Hospitalist. He is also a reviewer for the Archives of Internal Medicine, Annals of Internal Medicine, Chest, Journal of Thrombosis and Thrombolysis, Journal of Thrombosis and Hemostasis and JAMA. He is co-editor of the book Medical Management of the Surgical Patient and co-chairs for a national course on the perioperative care of the surgical patient with medical problems.
Dr. Merli is a fellow of the American College of Physicians and a member of American Venous Forum, the Society of Hospital Medicine, American Medical Association, Society of Vascular Medicine and Biology, and the International Society of Thrombosis and Hemostasis
Dr. Geno Merli Honored at Gala
No full textGeno J. Merli, MD, ’75, MACP, FHM, FSVM, received the Achievement Award in Medicine at the 23rd Annual Jefferson Gala on November 18, 2025. The award recognizes Dr. Merli’s extraordinary contributions to medical education and vascular medicine over a distinguished five-decade career.
Now Senior Vice President and Associate Chief Medical Officer at Thomas Jefferson University Hospital, Dr. Merli has been a cornerstone of Jefferson’s medical community since completing residencies in rehabilitation medicine and internal medicine. He served as Chief Resident in Rehabilitation Medicine in 1978. In the decades since, he has trained generations of physicians and pioneered approaches to managing deep vein thrombosis and pulmonary embolism that have become standard practice nationwide.
Since 2013, Dr. Merli has co-hosted “Annals Consult Guys” – a popular web series produced by the American College of Physicians – with Howard H. Weitz, MD, FACP, FACC, the Bernard L. Segal Endowed Professor in Clinical Cardiology at Jefferson. The duo has hosted more than 125 episodes, bringing fresh perspectives to complex medical cases through engaging discussions and in-depth analyses.
Dr. Merli has been recognized with several esteemed designations, including Master of the American College of Physicians, Fellow of the Society of Hospital Medicine, and Fellow of the Society for Vascular Medicine. He also chairs the Governance Committee of the Pulmonary Embolism Response Team (PERT) Consortium and holds membership in numerous professional societies dedicated to advancing cardiovascular care.
His commitment to innovation in patient care continues today. Most recently, under his leadership, the Division of Vascular Medicine received a $10,000 grant from the Thomas Jefferson University Hospital Women’s Board to launch the CATCHem (Comprehensive Atherosclerosis Treatment Collaborative Health System) program at the Jefferson Vascular Center, part of the Bruce & Robbi Toll Heart and Vascular Institute. This initiative expands access to critical screening and treatment services for patients with peripheral arterial disease, reflecting Dr. Merli’s ongoing dedication to improving outcomes for underserved populations.
“The Achievement Award in Medicine is a muchdeserved recognition not only of Dr. Merli’s remarkable clinical and educational achievements but also his mentorship of countless medical students, residents, and fellows who have gone on to leadership positions across the country,” says Charles J. Yeo, MD, FACS, Enterprise Chair of Surgery. “He has made, and continues to make, a lasting impact on our institution, the community, and the field of medicine.
Grateful Mother Honors Merli: ‘Great Doctor, Even Better Human Being’
No full textFor Peggy Bertorelli, family has always come first. The 77-year-old has devoted her life to loving and caring for her husband, three children and their spouses, and her eight grandchildren. Recent years have brought heartbreaking changes to her family: the loss of her son, Andrew, following a brief illness in 2021 and her husband, David, in 2024.
More than 20 years ago, she nearly lost her daughter, Cristina. Through that ordeal, she met Geno J. Merli, MD. Dr. Merli, who is now celebrating 50 years of service at Jefferson Health, quickly became an honorary member of the Bertorelli clan.
In December 2003 – just weeks before Cristina’s wedding – severe blood clots in her abdomen prompted the family to seek emergency treatment at Thomas Jefferson University Hospital. Bertorelli, a retired school nurse who lives in Lincroft, NJ, recalls the feelings of overwhelming fear as they navigated Cristina’s condition, which required them to reschedule her wedding.
Bertorelli still vividly remembers Dr. Merli’s role in leading the team that helped Cristina make a full recovery. She appreciates the expert clinical care that was pivotal to restoring Cristina’s health. But she’s equally grateful for Dr. Merli’s compassion, which she says was a source of strength and hope for the entire family.
“We met Dr. Merli by chance, and it was instant comfort,” Bertorelli says. “We felt like he truly cared about Cristina.”
On Christmas Eve, Bertorelli’s late husband reached out to Dr. Merli for moral support: “He talked to my husband on the phone for 40 minutes to help get him back on track,” she says. “I will never forget that.”
Over the past 20 years, she has expressed the family’s gratitude by making an annual gift to honor Dr. Merli and support his work in vascular medicine.
“No matter what your career, you have to exude compassion,” she reflects. “It’s something Dr. Merli would have even if he worked at a deli counter. He’s a great doctor but an even better human being.”
Someday soon, Bertorelli hopes to bring her grandchildren for a visit. As she puts it, “Dr. Merli needs to see the fruits of his labor – Cristina’s three children who, along with my other five grandchildren, are the light of my life.”
To learn more or make a gift online, please visit: jefferson.edu/GiveSurgery or contact Kelly Austin at 215-955-6383 or [email protected]
sj-pdf-1-vmj-10.1177_1358863X211047270 – Supplemental material for Apixaban Discontinuation for Invasive Or major Surgical procedures (ADIOS): A prospective cohort study
No full textSupplemental material, sj-pdf-1-vmj-10.1177_1358863X211047270 for Apixaban Discontinuation for Invasive Or major Surgical procedures (ADIOS): A prospective cohort study by Geno J Merli, Walter K Kraft, Luis H Eraso, Taki Galanis, Lynda J Thomson, Geoffrey O Ouma, Eugene Viscusi, Jerald Z Gong and Edwin Lam in Vascular Medicine</p
Nota sul Silio 'politico' negli epigrammi di Marziale
No full textIn Martial’s epigrams Silius Italicus is portrayed as a man of learning, author of the Punica and admirer of Vergil’s works, but also as a public figure and a former consul of Rome. My paper focuses on the epigrams devoted to the ‘political’ Silius, and suggests to relate them mainly to a certain stage in Silius Italicus’ life and to a specific communication strateg
La lima e il testo da Ovidio a Marziale: poetica e comunicazione
No full textIn the poetic texts from the Imperial age (from exiled Ovid to Martial and Statius) the metaphor of poetic lima undergoes
a deep transformation: the lima is no longer in the hands of the poet, who polishes his verses for years and years, but
(often) in those of a cultivated patron, requested by the author to correct the book before publication.
In the Flavian age the lima is then placed within the complex communication system of literary patronage, where it
becomes an element of homage and compliment. However, the metaphor never loses its original poetological meaning:
both Martial and Statius use it differently, in relation to themselves and in relation to intellectual patrons, thus subtly
reaffirming their own different and higher commitment to literature
Un'idea di Marziale : a proposito di un recente commento al V libro degli epigrammi
No full textThe article discusses some aspects of the fifth book of Martial's epigrams, starting from the new commentary by A Canobbio (Naples 2011). The structure of the book's prefatory section (epigr. 1-20) is particularly interesting because it creates a complex strategy of communication to the audience princepy, patrons, anonymous lector) and of self-fashioning of the author. The intertextual relationship with poetic authorities of the Augustan age, especially Horace and Ovid, is strongly present here while in the corpus of the book the dialogue with Catullus and the theater of Plautus becomes more evident - As Canobbio shows in relation to the 'cycle' of the subsellia. The fifth book proves to be a complex poetic text which enacts a multi-level dialogue with the Roman public and with the Latin literary tradition
La lima e il testo da Ovidio a Marziale : poetica e comunicazione
No full textIn the poetic texts from the Imperial age (from exiled Ovid to Martial and Statius) the metaphor of poetic lima undergoes
a deep transformation: the lima is no longer in the hands of the poet, who polishes his verses for years and years, but
(often) in those of a cultivated patron, requested by the author to correct the book before publication.
In the Flavian age the lima is then placed within the complex communication system of literary patronage, where it
becomes an element of homage and compliment. However, the metaphor never loses its original poetological meaning:
both Martial and Statius use it differently, in relation to themselves and in relation to intellectual patrons, thus subtly
reaffirming their own different and higher commitment to literature
Stability of wide-graded rubble mounds
No full textThe reshaping of temporary rubble mounds like the core of breakwaters or reclamation bunds is often a concern for contractorsi n the construction stages of marine structures. The formulas found in literature for the prediction of such behavior are few, and they do not provide clear insight on the influence of relevant parameters, in particular the small dimensions and wide stone-size gradation of the material involved, usually consisting of quarry run or resulting from dredging. The previous research in the field of dynamic stability focused on berm breakwaters and gravel beaches. These two typologies of structures define the range to which the rubble mounds considered in this study generally belong. An overview on the design tools provided by the technical literature shows that, whenever the grading was included as a governing parameter, some influence was recognized in the characteristics of the structure (e.g. the permeability) and in the dynamism of the different fractions of stone sizes. However, very wide ranges of the parameter grading were never investigated and a specific analysis in this direction constitutes the main significance of this study. The Delft University of Technology provided the laboratory facilities to carry out physical model tests on a wide graded rubble mound structure representative of the core of a breakwater. The parameter D85/D15, describing the stone-size gradation of the construction material, was varied between the values 2.71 and 17.7, and two different seaward slopes of the model structure were also tested. The reshaped cross-shore profiles measured during the tests showed how if the grading increases the stability of the structure is reduced. This is not always in accordance with the findings of previous researchers, showing how the extrapolation of existing empirical formulas to structures with high values of the ratio D85/D15 do not give reliable results. Instead, the formulas given by van de Meer (1992) to estimate the whole reshaped profile of a dynamic slope predict with good agreement the shape of the measured profiles, although the physical model shows a larger horizontal extension of the displacements. This difference is governed by the grading, being more noticeable as this parameter increases. This result leads to the definition of new formulas, some of them being modifications of the ones given by van der Meer, to describe the geometry of a reshaped profile. The formulas, all including the parameter grading, are derived through curve fitting of the measured data. Also a formula for the direct estimation of the crest recession is given. As a final step, a simple numerical model is proposed in which the new formulas are implemented, constituting a quick way to assess the shape of a slope after a wave attack. As a suggestion for further utilization of the results of physical modeling, a brief comparison is also carried out between the output of the tests and the prediction of the numerical model XBeach (developed mainly at UNESCO-IHE). In conclusion, this research points out how the formulas provided by the technical literature are not reliable in representing the effects of a very wide stone-size gradation in the stability of a rubble mound structure. Physical model tests proved to be a suited way to investigate these effects, as the nature of the phenomena who play a role in the stability does not allow a simple analytical representation. The tests carried out within the present study lead to the implementation of a numerical model of practical use for engineers and contractors: further investigations through laboratory tests are recommended to validate and extend the findings of this study. Another proposed direction for further research is the comparison between the results of physical model tests and the output of numerical models.Hydraulic EngineeringCivil Engineering and Geoscience
Bleeding with direct oral anticoagulants vs warfarin: clinical experience
No full textAbstractThe risk of bleeding in the setting of anticoagulant therapy continues to be re-evaluated following the introduction of a new generation of direct oral anticoagulants (DOACs). Interruption of DOAC therapy and supportive care may be sufficient for the management of patients who present with mild or moderate bleeding, but in those with life-threatening bleeding, a specific reversal agent is desirable. We review the phase 3 clinical studies of dabigatran, rivaroxaban, apixaban, and edoxaban in patients with nonvalvular atrial fibrillation, in the context of bleeding risk and management
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