997,353 research outputs found
Patrimonio culturale e festività dei carnevali: gli itinerari urbani dei rituali storici in Campania
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Toro-Tapia poster BSDB
No full textDifferentiating neurons delaminate from the neuroepithelium via the process of apical abscission, which involves loss of apical polarity and primary cilium disassembly. This corresponds with cessation of canonical, Gli transcription factor-dependent Shh signalling and leads to cell cycle exit. Newborn neurons undergo a switch to non-canonical, transcription factor-independent Shh signalling, which mediates axon navigation. As cilia play important roles transducing extracellular signals, it is conceivable that the switch from canonical to non-canonical Shh signalling is mediated by remodelling the cilium during early stages of neuronal differentiation. Live tissue imaging reveals that differentiating neurons retain an Arl13b+ particle which elongates and progressively initiates intraflagellar trafficking as it transits towards the cell body, indicating cilium remodelling. Strikingly, disruption of cilia during and after remodelling inhibits axon extension and leads to dramatic axon collapse respectively. Remarkably, ciliary accumulation of the Shh transducer Smoothened is progressively restored during cilium remodelling in the absence of Gli transcriptional activity. Furthermore, the remodelled cilium also accumulates GPR161, a negative regulator of Gli dependent Shh signalling. These results indicate that newborn neurons are responding to Shh via a non-canonical pathway through the remodelled cilium, providing differentiating neurons the opportunity to configure a new signalling centre. </p
Choice Experiments in Enviromental Impact Assessment: The Toro 3 Hydroelectric Project and the Recreo Verde Tourist Center in Costa Rica
No full textChoice experiments, a stated preference valuation method, are proposed as a tool to assign monetary values to environmental externalities during the ex-ante stages of environmental impact assessment. This case study looks at the impacts of the Costa Rican Institute of Electricity’s Toro 3 hydroelectric project and its affects on the Recreo Verde tourism center in San Carlos, Costa Rica. Compared to other valuation methods (e.g., travel cost and contingent valuation), choice experiments can create hypothetical but realistic scenarios for consumers and generate restoration alternatives for the affected good. Although they have limitations that must be taken into account in environmental impact assessments, incorporating economic parameters—especially resource constraints and tradeoffs—can substantially enrich the assessment process.stated-preference, economic valuation, choice experiments, hydropower, tourism, Costa Rica
Prefazione
No full textLe politiche sull’ambiente assumono un ruolo fondamentale e sempre più importante, perché possono riuscire a modificare quei comportamenti che, se accompagnati a politiche economiche di sostenibilità, possono permetterci di raggiungere un equilibrio tra la salvaguardia delle risorse naturali esistenti, e un loro corretto utilizzo, in modo da proteggerne l’integrità.
Il volume contiene i contributi presentati in occasione del convegno organizzato dall’AIL e dall’Università degli studi di Palermo su “Cancerogenesi Ambientale” (Palermo 2013)
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