1,179 research outputs found
Enterotoxigenic Escherichia coli Flagellin Inhibits TNF-Induced NF-κB Activation in Intestinal Epithelial Cells
No full textCitation: Wang, G.; Geisbrecht, B.V.; Rueter, C.; Hardwidge, P.R. Enterotoxigenic Escherichia coli Flagellin Inhibits TNF-Induced NF-κB Activation in Intestinal Epithelial Cells. Pathogens 2017, 6, 18.Enterotoxigenic Escherichia coli (ETEC) causes childhood diarrhea in developing countries. ETEC strains produce the heat-labile enterotoxin (LT) and/or heat-stable enterotoxins (ST) and encode a diverse set of colonization factors used for adherence to intestinal epithelial cells. We previously found that ETEC secretes a heat-stable protein we designated as ETEC Secreted Factor (ESF) that inhibits the extent of NF-κB activation normally induced by tumor necrosis factor alpha (TNF). Here we fractionated ETEC supernatants using fast protein liquid chromatography (FPLC) and determined that ETEC flagellin was necessary and sufficient to protect IκBα from degradation in response to TNF stimulation. These data suggest a potentially novel mechanism by which ETEC may evade the host innate immune response by down-regulating NF-κB-dependent host responses
\u3ci\u3ePLIVA v. Mensing\u3c/i\u3e and Its Implications
No full textThe U.S. Supreme Court ruling in PLIVA Inc. v. Mensing will immunize generic drug manufacturers facing failure-to-warn claims from state-law liability, and may also have implications for preemption jurisprudence more generally, says attorney Brian Wolfman and co-author Dena Feldman in this BNA Insight. The authors analyze the ruling, and offer their views on the questions that PLIVA raises about the ongoing vitality of the presumption against preemption, the standard for determining ‘‘impossibility’’ preemption, and the propriety of deference to an agency’s views on preemption
Mannheimsia tianzena Brown 2005, comb. n.
No full textMannheimsia tianzena (Liu, 1995), comb. n. Figs 10, 13 Chouomyia tianzena Liu, 1995: 186, figs 1–10. Material examined: CHINA: Shaanxi, 1ơ 22.vi.1993, G. Liu (LACM). Remarks: The original description did not include the secondary process of the right hypandrial lobe; likely the author considered it to be part of the aedeagus. My illustration (Fig. 10) differs somewhat from that of Liu because it is drawn at a slightly different angle.Published as part of Brown, Brian V., 2005, Classification of two poorly known genera of African Phoridae (Diptera), pp. 133 in African Invertebrates 46 on page 139, DOI: 10.5281/zenodo.766688
Protein structure and function / Brian W. Matthews
No full textConsists of offprints of the author's articlesIncludes bibliographies1 v. (various pagings) :This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exceptions. If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legalsThesis (D. Sc.)--University of Adelaide, 198
FIGURE 9 in A Revision of the Australian species of Lynceus Müller, 1776 (Crustacea: Branchiopoda: Laevicaudata, Lynceidae)
No full textFIGURE 9. Images of sites where new species have been found. A, Peewah Ck, Pilbara, L. argillaphilus sp. nov., image courtesy A. Pinder, DEC, WA; B, middle gnamma in row of five,14.6 km N of Trayning, L. baylyi sp. nov., image by author; C, East Oak Park gnamma, via Goomalling, L. magdaleanae sp. nov., image by author; D. Gnamma in limestone, 12 km south of Cocklebiddy, Nullarbor Plain, L. susanneae sp. nov., image courtesy A. Clarke, DEC, WA. Gnammas B, C and D are the type localities for their respective species.Published as part of <i>TIMMS, BRIAN V, 2013, A Revision of the Australian species of Lynceus Müller, 1776 (Crustacea: Branchiopoda: Laevicaudata, Lynceidae), pp. 501-533 in Zootaxa 3702 (6)</i> on page 516, DOI: 10.11646/zootaxa.3702.6.1, <a href="http://zenodo.org/record/10099172">http://zenodo.org/record/10099172</a>
Staphylococcal Complement Inhibitors: Biological Functions, Recognition of Complement Components, and Potential Therapeutic Implications
No full textTwo Saints : The martyrdom of St. Sergius & St. Bacchus.
No full textBook 1 v. (unpaged) : col. ill. ; 23 cm.'This second offering from Seven Hills Press was printed in late spring 2004. The paper is a conglomeration of cotton, abaca, and iris leaves from the garden. The cover stock has been dyed with black walnut stain provided by Lisa Beth Robinson. The typeface is primarily Garamond.' -- Colophon. Limited ed. of 35. Concertina binding with signatures stitched in.Signed by the author/printer/artist Brian Borchardt. No. 12 of a limited ed
Host Glycan Recognition by a Pore Forming Toxin
No full textAn exposed F-type lectin domain fused to the N-terminus of a cholesterol-dependent cytolysin scaffold allows Streptococcus mitis lectinolysin to cluster at fucose-rich sites on target cell membranes, thereby leading to increased pore-forming toxin activity. In this issue of Structure, Feil and coworkers define the structural basis for lectinolysin glycan-binding specificity
Psychometric properties of the Jewish beliefs actions and living evaluation middle school form
No full textThere is significant empirical support for the positive short- and long-term academic, behavioral, social, and emotional outcomes associated with religiosity and spirituality. A review of the literature suggests that preadolescence is a key period for religious and spiritual development. There is a need for a reliable and valid measure to assess the religiosity and spirituality of preadolescents. The purpose of this study is to evaluate the psychometric properties of the Jewish Beliefs Actions and Living Evaluation (JewBALE) Middle School Form, a 186-item survey designed to assess preadolescents in the core components of Modern Orthodox Judaism. Modern Orthodoxy is a sect of Judaism that tries to balance religious obligation with engagement of the modern world. The JewBALE Middle School Form is a downward extension of a JewBALE High School Form and consists of 2 composites - Total Beliefs and Total Actions. Subjects included 176 children (ages 10 to 14) attending a Modern Orthodox Jewish residential camp in Northern Pennsylvania during the Summer of 2011. Findings from the study suggest that there are no gender or grade differences between subjects on Total Beliefs and Total Actions mean scores. Both composites demonstrate good internal consistency reliability. Principal components analysis using oblimin rotation indicates that there are 17 factors that underlie the JewBALE Middle School Form. Correlations between newly added items and composite scores indicate strong relationships between items related to the Bar and Bat Mitzvah experience and other items, while only limited relationships exist between bullying items and composite scores. These results provide evidence for the reliability and validity for the JewBALE Middle School Form as a measure of religiosity and spirituality of Modern Orthodox Jewish preadolescents. Limitations of the study are discussed and recommendations are offered in terms of improving the measure.Psy. D.Includes bibliographical referencesby Brian Jay Friedma
Chief Justice Brian Dickson's Influence in Interpreting the Charter
No full textBrian Dickson was the first chief justice during the enactment of The Canadian Charter of Rights and Freedoms. The Charter is enshrined in the Canadian constitution and became the supreme law of Canada when enacted with the purpose being to protect the rights and freedoms it established for Canadians. Dickson’s exceptional impact on a variety of cases led him to being one of the most revered figures in Canadian legal history. His numerous landmark decisions are accentuated by his abounding number of Supreme Court decisions that have affirmed many aspects of the Charter. This thesis will attempt to highlight his many decisions and the sections of the Charter they recognized. This will be done by analyzing Dickson’s reasoning through a qualitative study. A mixed method research design will be paired with a mixture of purposive and convenience sampling to acquire cases with the greatest thematic value. Then, a thematic analysis will be conducted to highlight Dickson’s interpretation of the case and the language of the Charter. The five cases chosen for this thesis will be the s.8 case of Hunter et.al v. Southam Inc. (1984), a s.2 freedom of religion case in R. v. Big M Drug Mart Ltd (1985), a s.1 and s.11(d) case of R. v. Oakes (1986), a s.2(b) freedom of expression case in Irwin Toy Ltd. v. Quebec (Attorney General) (1989) and a s.15 case in Andrews v. Law Society of British Columbia (1989). The chosen cases are described as being the first major decisions for their respective Charter sections and will help illustrate the important effect Dickson had in setting up the Canadian Charter of Rights and Freedoms for its sustained and ever-lasting success
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