98,151 research outputs found
Ausgewaehlte Probleme der Strukturmechanik. Sammlung der Vortraege des Kolloquiums am 11. Mai 1995 zu Ehren von Herrn Dr.-Ing. Bodo Geier. T. 1
No full textTo honor Dr. Geier, the Institute for Structural Mechanics organized a scientific colloquium on 11 May 1995, the topics of which are oriented both to the special scientific interests of Dr. Geier and to the future responsibilities of the institute. The present report contains summaries of the contributions to the colloquium documenting the contributions concerning quick design, design rules and standards for structural calculation; sandwiches, an analytical tidbit; calculation of the buckling load reduction as a result of stringer separation; experimental investigations into the buckling of imperfectly loaded CFRP shells; numerical analysis of future thermostable structures; and adaptive structure systems - state of the art and perspectives. (orig./RHM)SIGLEAvailable from TIB Hannover: RN 4165(1995,13) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman
Joshua Davis: Author of Spare Parts
No full textCitation: K-State First (2016). Joshua Davis: Author of Spare Parts [Flier]. Manhattan, Kansas: K-State First.Flyer advertising Joshua Davis's author talk at Kansas State University
Steven Johnson Author Talk Poster
No full textK-State Book NetworkA poster advertising an author talk by Steven Johnson at Kansas State University on September 3, 2014. Steven Johnson's book "The Ghost Map" was the 2014-2015 common book
Histone deacetylase inhibitors, Thimerosal, and autism spectrum disorder
No full text[no abstract available
SHOTGLAS
No full textThe presence of extreme horizontal branch (EHB) and blue hook stars in some Galactic globular clusters (GGCs) constitutes one of the remaining mysteries of stellar evolution. While several evolutionary scenarios have been proposed to explain the characteristics of this peculiar population of evolved stars, their observational verification has been limited by the availability of spectroscopic data for a statistically significant sample of such objects in any single GGC. We recently launched the SHOTGLAS project with the aim of providing a comprehensive picture of this intriguing stellar population in terms of spectroscopic properties for all readily accessible GGCs hosting an EHB. In this first paper, we focus on ω Cen, a peculiar, massive GGC that hosts multiple stellar populations. We use non-LTE model atmospheres to derive atmospheric parameters (Teff, log g and N(He)/N(H)) and spectroscopic masses for 152 EHB stars in the cluster. This constitutes the largest spectroscopic sample of EHB stars ever analyzed in a GGC and represents ≈20% of the EHB population of ω Cen. We also search for close binaries among these stars based on radial velocity variations. Our results show that the EHB population of ω Cen is divided into three spectroscopic groups that are very distinct in the Teff − helium abundance plane. The coolest sdB-type stars (Teff ≲ 30 000 K) have a hydrogen-rich atmosphere, populate the theoretical EHB region in the Teff − log g plane, and form 26% of our sample. The hottest sdO-type stars (Teff ≳ 42 000 K) make up 10% of the sample, have a hydrogen-rich atmosphere and are thought to be in a post-EHB evolutionary phase. The majority of our sample is found at intermediate temperatures and consists of sdOB stars that have roughly solar or super-solar atmospheric helium abundances. It is these objects that constitute the blue hook at V > 18.5 mag in the ω Cen color-magnitude diagram. Interestingly, the helium-enriched sdOBs do not have a significant counterpart population in the Galactic field, indicating that their formation is dependent on the particular environment found in ω Cen and other select GGCs. Another major difference between the EHB stars in ω Cen and the field is the fraction of close binaries. From our radial velocity survey we identify two binary candidates, however no orbital solutions could be determined. We estimate an EHB close binary fraction of ≈5% in ω Cen. This low fraction is in line with findings for other GGCs, but in sharp contrast to the situation in the field, where around 50% of the sdB stars reside in close binaries. Finally, the mass distribution derived is very similar for all three spectroscopic groups, however the average mass (0.38 M⊙) is lower than that expected from stellar evolution theory. While this mass conundrum has previously been noted for EHB stars in ω Cen, it so far appears to be unique to that cluster
Developmental neurotoxicants and the vulnerable male brain: a systematic review of suspected neurotoxicants that disproportionally affect males
No full textThe prevalence of neurodevelopmental disorders (NDs), including autism spectrum disorder, attention‐deficit/hyperactivity disorder, tic disorder, obsessive‐compulsive disorder, and emotional disturbances, has increased notably in the past few decades. To date, debate continues as to the origins of NDs. Increases in widespread exposure to and bioaccumulation of chemical neurotoxicants have paralleled the upsurge in NDs, and are suggested to be causal agents for NDs. One consistent aspect of NDs is the male preponderance. This review considers the issue of male preponderance by reviewing the gender‐specific neurotoxic effects of recognized neurotoxicant chemicals to assess their possible etiology in NDs. This investigation consisted of a systematic literature review of original studies published from 1970-2016 on suspected neurotoxicants, to examine whether they have a disproportionate adverse effect based on gender. Based on that review, the neurotoxicants exhibiting consistent gender‐specific effects, with exposed males being more affected (than similarly exposed females), were: lead, Thimerosal/ethylmercury, some organochlorine pesticides (e.g., dieldrin, endosulfan, and heptachlor), and air pollution. The next group identified were neurotoxicants exhibiting gender‐specific neurotoxic effects, with males being somewhat (but not consistently) more affected than females: mercury vapor, polychlorinated biphenyls (PCBs), and organophosphate pesticides. Finally, there was a group of studies in which the neurotoxicants exhibited apparent gender‐related neurotoxic effects but failed to show whether exposed males were consistently more affected than females: inorganic mercury salts, methylmercury species, and certain endocrine disruptors (e.g., phthalates and BPA). The overall conclusion from the studies reviewed was that the brain in males is more vulnerable to many toxic exposures than it is in females. Evidence suggests that the reasons for the male brain being more vulnerable include: (1) greater glutathione availability in females; (2) greater sulfate‐based detoxification capacity in females; (3) potentiating effects of co‐exposure to neurotoxicants and testosterone; (4) greater neuroinflammatory response in males; (5) reduced vulnerability to oxidative stress in females; and (6) neuroprotective effects of female hormones (estrogen and progesterone), especially in the reduction of inflammation and oxidative stress
Immune dysfunction and neuroinflammation in autism spectrum disorder
No full textAutism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder with a complex pathogenesis. Many studies over the last four decades have recognized altered immune responses among individuals diagnosed with ASD. The purpose of this critical and comprehensive review is to examine the hypothesis that immune dysfunction is frequently present in those with ASD. It was found that often individuals diagnosed with ASD have alterations in immune cells such as T cells, B cells, monocytes, natural killer cells, and dendritic cells. Also, many individuals diagnosed with ASD have alterations in immunoglobulins and increased autoantibodies. Finally, a significant portion of individuals diagnosed with ASD have elevated peripheral cytokines and chemokines and associated neuroinflammation. In conclusion, immune dysregulation and inflammation are important components in the diagnosis and treatment of ASD
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