202 research outputs found
Beyond the Trees: A Systems Approach to Understanding Forest Health in the Southeastern United States
No full textForest health is an important topic for biology, agriculture, current issues, and environmental science classes. But conversations with educators suggested that they were not equipped to teach about it given their existing curricula. This 79-page educator guide includes six activities designed to help learners consider forest health from various viewpoints; understand interrelationships and feedback mechanisms in a forest system; visualize spatial and temporal mechanisms of forest system functions; appreciate the variety of threats to forest health; and consider their role as future forest stewards. Written by Geetha S. Iyer, Martha M. Monroe, and Jason A. Smith, and published by the UF Department of School of Forest Resources and Conservation, July 2011.
FOR287/FR355: Beyond the Trees: A Systems Approach to Understanding Forest Health in the Southeastern United States (ufl.edu
Beyond the Trees: A Systems Approach to Understanding Forest Health in the Southeastern United States
No full textForest health is an important topic for biology, agriculture, current issues, and environmental science classes. But conversations with educators suggested that they were not equipped to teach about it given their existing curricula. This 79-page educator guide includes six activities designed to help learners consider forest health from various viewpoints; understand interrelationships and feedback mechanisms in a forest system; visualize spatial and temporal mechanisms of forest system functions; appreciate the variety of threats to forest health; and consider their role as future forest stewards. Written by Geetha S. Iyer, Martha M. Monroe, and Jason A. Smith, and published by the UF Department of School of Forest Resources and Conservation, July 2011.
FOR287/FR355: Beyond the Trees: A Systems Approach to Understanding Forest Health in the Southeastern United States (ufl.edu
What Is a Healthy Forest? A Supplement to Florida Project Learning Tree
No full textThere is no question that forests provide important ecological services and economic resources to Floridians. Similarly, there is no doubt that the health of our forests is at the mercy of how we manage our landscape and make decisions. The activities in this supplement, with the original PLT Guide, help our students rise to these twin challenges. This 84-page handbook was written by Sarah L. Hicks, Martha C. Monroe, Geetha S. Iyer, and Jason A. Smith, and published by the UF Department of School of Forest Resources and Conservation, July 2011.
FOR286/FR354: What Is a Healthy Forest? A Supplement to Florida Project Learning Tree (ufl.edu
What Is a Healthy Forest? A Supplement to Florida Project Learning Tree
No full textThere is no question that forests provide important ecological services and economic resources to Floridians. Similarly, there is no doubt that the health of our forests is at the mercy of how we manage our landscape and make decisions. The activities in this supplement, with the original PLT Guide, help our students rise to these twin challenges. This 84-page handbook was written by Sarah L. Hicks, Martha C. Monroe, Geetha S. Iyer, and Jason A. Smith, and published by the UF Department of School of Forest Resources and Conservation, July 2011.
FOR286/FR354: What Is a Healthy Forest? A Supplement to Florida Project Learning Tree (ufl.edu
What Is a Healthy Forest? A Supplement to Florida Project Learning Tree
No full textThere is no question that forests provide important ecological services and economic resources to Floridians. Similarly, there is no doubt that the health of our forests is at the mercy of how we manage our landscape and make decisions. The activities in this supplement, with the original PLT Guide, help our students rise to these twin challenges. This 84-page handbook was written by Sarah L. Hicks, Martha C. Monroe, Geetha S. Iyer, and Jason A. Smith, and published by the UF Department of School of Forest Resources and Conservation, July 2011.
FOR286/FR354: What Is a Healthy Forest? A Supplement to Florida Project Learning Tree (ufl.edu
Beyond the Trees: A Systems Approach to Understanding Forest Health in the Southeastern United States
No full textForest health is an important topic for biology, agriculture, current issues, and environmental science classes. But conversations with educators suggested that they were not equipped to teach about it given their existing curricula. This 79-page educator guide includes six activities designed to help learners consider forest health from various viewpoints; understand interrelationships and feedback mechanisms in a forest system; visualize spatial and temporal mechanisms of forest system functions; appreciate the variety of threats to forest health; and consider their role as future forest stewards. Written by Geetha S. Iyer, Martha M. Monroe, and Jason A. Smith, and published by the UF Department of School of Forest Resources and Conservation, July 2011.
FOR287/FR355: Beyond the Trees: A Systems Approach to Understanding Forest Health in the Southeastern United States (ufl.edu
Extramedullary Relapse of Acute Promyelocytic Leukaemia (APL) at an Unusual Site (External Auditory Canal)
No full textThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work
is properly cited, the use is non-commercial and no modifications or adaptations are made.
© 2025 The Author(s). eJHaem published by British Society for Haematology and John Wiley & Sons Ltd
Characterization of germ cell development in free-living and parasitic flatworms
No full textSexually reproducing organisms must ensure correct specification and maintenance of germ cells for species survival. Germ cells must be carefully protected from inappropriate differentiation while simultaneously maintaining their identity as highly specialized totipotent cells. Several germ cell-intrinsic mechanisms, including transcriptional and post-transcriptional regulation, are key to executing germ cell-specific processes. Study of molecules necessary for the proper specification, maintenance, and differentiation of germ cells can lead to a deeper understanding of mechanisms underlying totipotency, infertility, tumorigenesis, evolutionary development, and even pathogenesis. Here we study germ cells in the context of both free-living and parasitic flatworms. We use the freshwater planarian Schmidtea mediterranea to understand the functions of germ cell-specific genes crucial for the development and proliferation of early male germ cells. Additionally, we also characterize genes essential for the tremendous reproductive output of the parasite Schisosoma mansoni, a causative agent of the a major neglected tropical disease, schistosomiasis.
It was recently shown that in S. mediterranea, a male germ cell-specific component of the ubiquitous Nuclear Factor-Y family of transcription factors, NF-YB, is necessary for testis maintenance. In Chapter 2, we characterize the cellular mechanism behind NF-YB-mediated maintenance of the male germline stem cells, known as spermatogonial stem cells, or SSCs. We demonstrate that NF-YB is not necessary for the specification of germ cells, but plays a role in the self-renewal and proliferation of SSCs. Furthermore, we show that other components of the NF-Y complex in S. mansoni are similarly necessary for the proliferation of male germ cells, indicating molecular and functional conservation of this family of transcription factors.
Next, we characterize the planarian homologs of boule, which belongs to a family of RNA-binding proteins known to play important roles in human infertility. In Chapter 3, we adopt an evolutionary-developmental approach and show that unlike other invertebrate boule genes, one of the planarian boule paralogs is required for SSC maintenance. Intriguingly, this early germ cell function, thought to be specific to vertebrate representatives of this gene family, appears to have evolved independently and earlier than previously thought. Our results demonstrate that the planarian can be a tractable invertebrate model system for understanding the germ cell functions of genes that are conserved between planarians and vertebrates.
Finally, in Chapter 4, we perform an unbiased transcriptomic screen to identify genes necessary for germ cell development in the parasite S. mansoni. The prodigious egg laying capacity of these parasites is the cause behindunderlies the morbidity of the disease schistosomiasis. Using a large-scale RNA interference-based functional approach, we identify genes functioning in different stages of schistosome male gametogenesis, as well as genes necessary for egg production in the mammalian host.
Together, our studies uncover novel roles for numerous genes critical for germ cell development in free-living and parasitic flatworms.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-08-01The student, Harini Iyer, accepted the attached license on 2017-07-11 at 12:09.The student, Harini Iyer, submitted this Dissertation for approval on 2017-07-11 at 12:17.This Dissertation was approved for publication on 2017-07-12 at 10:28.DSpace SAF Submission Ingestion Package generated from Vireo submission #11397 on 2017-09-29 at 11:18:30Made available in DSpace on 2017-09-29T16:39:43Z (GMT). No. of bitstreams: 2
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Previous issue date: 2017-07-12Embargo set by: Colleen Fallaw for item 103421
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Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemLimited Restriction Lifted for Item 103421 on 2019-09-30T09:15:29Z
miR-125b toggles dynamics and structure of dendritic filopodia in developing hippocampal neurons
No full textThe wiring of the nervous system is an intricate process of self-organization, of unparalleled complexity in the natural world. To get a sense of the scope of the requirement, imagine all the billions of phones and computers connected by wires to form the internet. Imagine if these wires branch out and divide, avoiding inimical landscapes and waters, to reach the right servers and computers, which turn had to send out wires to meet yet other servers and so on, till you have the internet of today. Now imagine that instead of a few billion computers, you had eighty-six billion neurons. Instead of men laying down the wiring on pre-programmed routes, the wires had to grow on their own. And instead of the lands and seas of Earth, you had to achieve all this in the space of a single human skull. This is the self-organization challenge of the axons and dendrites of the brain.
Developing dendrites encounter a variety of stimuli that direct their growth and final architecture. Cellular substrates respond to these stimuli, integrating extrinsic information to direct dendritic growth. Of interest in this process are microRNAs, small noncoding RNAs around 22 nucleotides long, which can reversibly repress local translation in dendrites. By responding to external cues sensed by dendritic filopodia, they participate in the key decision-making processes in developing dendrites: where and how to grow.
This study focuses on the role of miR-125b, a brain abundant microRNA, for its role in the dynamics and structure of filopodia in developing dendrites. We inhibited miR- 125b’s activity in cultured hippocampal neurons during the early stages of development as filopodia explore their microenvironment. We show that miR-125b function is critical for maintaining the structural features of filopodia, and that inhibiting its function changes the distribution of the type of protrusions emerging from dendritic shafts. Inhibiting miR-125b increases dendritic expression and localization of the GluN2A subunit of the NMDA receptor, and we show that dendritic GluN2A is correlated with maintaining filopodial morphology. Using Spatial Light Interference Microscopy (SLIM), we show that miR-125b function contributes to maintaining the dynamicity of filopodia. We propose that miR-125b is critical in maintaining the filopodial phenotype early in dendrite development, thus contributing to dendritogenesis and spinogenesis. Through its regulation of GluN2A, miR-125b shapes neuronal response to the synaptotrophic factor glutamate. These high-resolution analyses reveal fresh insights into the process by which neurons integrate multiple external signals to establish the correct connections. Such insights are critical to understanding the implicated role of miR125b in various neurological disorders like Fragile X Syndrome and Alzheimer’s disease.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2020-05-01The student, Rajashekar Iyer, accepted the attached license on 2018-04-13 at 23:18.The student, Rajashekar Iyer, submitted this Dissertation for approval on 2018-04-13 at 23:35.This Dissertation was approved for publication on 2018-04-15 at 09:28.DSpace SAF Submission Ingestion Package generated from Vireo submission #12247 on 2018-08-31 at 17:29:01Made available in DSpace on 2018-09-04T20:47:14Z (GMT). No. of bitstreams: 4
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Previous issue date: 2018-04-15Embargo set by: Seth Robbins for item 107400
Lift date: 2020-09-04T20:47:38Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 107400
Lift date: 2020-09-04T20:50:11Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemLimited Restriction Lifted for Item 107400 on 2020-09-05T09:15:20Z
Closed-form solutions for the analysis of artificial dielectric layers under generic field incidence
No full textWe present an analytical method to model artificial dielectric layers (ADLs) of finite height. Starting from the closed-form solution for the scattering from a single layer under plane wave illumination, the formulation is extended to the multi-layer case, by including the higher-order interaction between parallel layers in analytical form. The method can be used to describe the radiation of a source located in the close proximity of the ADL. Experimental data obtained from a prototype demonstrator are presented and show a good agreement with the results of the theoretical analysis.Accepted author manuscriptTera-Hertz Sensin
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