145 research outputs found
Novel pharmaceutical salts of albendazole
No full textAlbendazole (ABZ) is a class II safe and effective antihelmintic drug in the benzimidazole group according to the BCS (Biopharmaceutics Classification System) with low solubility (9 mg L-1) and high permeability (logP 2.54). Novel salts and salt hydrates of ABZ are reported with benzene and p-toluene sulfonic acid (BSA, PTSA), as well as carboxylic acids such as oxalic acid (OA), maleic acid (MLE), l-tartaric acid (LTA), 2,6-dihydroxybenzoic acid (2,6-DHBA), and 2,4,6-trihydroxybenzoic acid (2,4,6-THBA). The products ABZ-BSA, ABZ-BSA-H, ABZ-PTSA, ABZ-PTSA-H, ABZ-OA-H and ABZ-2,6-DHBA were confirmed by single crystal X-ray diffraction. In the hydrate structures (designated as -H), the water molecule acts as a bridge in the hydrogen bonding network. The salt formation of ABZ-MLE, ABZ-LTA, and ABZ-2,4,6-THBA was confirmed by 15N ss-NMR based on the chemical shift change of ca. 50 ppm. The sulfonate salt hydrates exhibit 2D isostructurality, and position disorder in the thiopropyl group in the drug crystal structure was not observed in the salts. Crystal lattice energies were calculated for the MLE, LTA, and 2,4,6-THBA complexes of ABZ to confirm the molecular salt formation. The cocrystals of ABZ with the hydroxybenzene carboxylic acids are novel salts in the benzimidazole drugs class
SURMOF induced polymorphism and crystal morphological engineering of acetaminophen polymorphs: advantage of heterogeneous nucleation
No full text© 2018 The Royal Society of Chemistry. Self-assembled monolayers are extended to SURMOFs as template hetero surfaces using a basic HKUST-1 MOF. The concept of MOF induced polymorphism with morphological engineering adapted to crystal engineering has shown to have the advantage of heterogeneous nucleation. The substrates are used to study the nucleation and growth of acetaminophen, and have resulted in metastable polymorphs which are of a desirable form with block morphology
Binary and ternary cocrystals of sulfa drug acetazolamide with pyridine carboxamides and cyclic amides
No full textA novel design strategy for cocrystals of a sulfonamide drug with pyridine carboxamides and cyclic amides is developed based on synthon identification as well as size and shape match of coformers. Binary adducts of acetazolamide (ACZ) with lactams (valerolactam and caprolactam, VLM, CPR), cyclic amides (2-pyridone, labeled as 2HP and its derivatives MeHP, OMeHP) and pyridine amides (nicotinamide and picolinamide, NAM, PAM) were obtained by manual grinding, and their single crystals by solution crystallization. The heterosynthons in the binary cocrystals of ACZ with these coformers suggested a ternary combination for ACZ with pyridone and nicotinamide. Novel supramolecular synthons of ACZ with lactams and pyridine carboxamides are reported together with binary and ternary cocrystals for a sulfonamide drug. This crystal engineering study resulted in the first ternary cocrystal of acetazolamide with amide coformers, ACZ–NAM–2HP (1:1:1)
Integration Architecture Fundamentals for Healthcare Systems: A Framework for Seamless Interoperability
No full textIntegration architecture forms the foundation of modern healthcare information ecosystems, enabling disparate systems to communicate effectively and securely. The proliferation of specialized healthcare applications has created significant interoperability challenges, with fragmented systems hampering coordinated care delivery and operational efficiency. This article examines the fundamental components of healthcare integration architecture Application Programming Interfaces (APIs), middleware solutions, and data standards and their collective role in establishing seamless interoperability. The implementation of robust integration architecture yields substantial benefits across multiple dimensions of healthcare delivery, including enhanced clinical decision-making, streamlined operational workflows, improved patient experiences, and optimized financial outcomes. However, healthcare organizations face significant challenges in implementing effective integration solutions, including legacy system integration, security considerations, scalability requirements, and complex regulatory compliance. Strategic approaches to addressing these challenges involve implementing adapter patterns for legacy systems, incorporating comprehensive security measures, adopting scalable architectural approaches, and establishing formal data governance frameworks. The global significance of healthcare integration continues to grow, with the interoperability market expanding rapidly as organizations recognize the critical importance of connected systems for delivering high-quality, cost-effective care in an increasingly complex healthcare landscape
Ventimiglia 2015: a visual story by Emanuele Giacopetti
No full textThis story created by Emanuele Giacopetti was initially published as "La Bolla" by Graphic News at https://www.graphic-news.com/stories/la-bolla-of-ventimiglia. We reproduce this visual novel as it provides a good understanding of the living conditions of migrant people in Ventimiglia. This content can be shared and adapted under the licence defined by the initial author, that is a Creative Commons Attribu..
SURMOF Induced Morphological Crystal Engineering of Substituted Benzamides
No full textWell-established,
self-assembled monolayers are further explored and extended to SURMOFs
as basic template heterosurfaces by using a basic stranded HKUST metal–organic
framework (MOF) as an example. The prepared SURMOF was used to study
morphological crystal engineering of substituted benzamides. Prepared
SURMOF substrates surfaces were analyzed by scanning electron microscopy
and confirmed through thin film X-ray diffraction. Here we proved
that the MOF surface exhibited adsorption of the substituted benzamides
nucleus during both nucleation and growth directed due to the weak
supramolecular interactions. MOF induced nucleation was investigated
and showed control over the substituted benzamides for morphological
engineering. Hence the concept of MOF induced morphological crystal
engineering is adapted to the field of morphology crystal engineering
and showed the additional advantage of heterogeneous nucleation
- …
