1,721,328 research outputs found
Liposomes modified by carbohydrate ligands can target B cells for the treatment of B-cell lymphomas
No full textBioorthogonal chemical reporter methodology for visualization, isolation and analysis of glycoconjugates
No full textThe recent development of metabolic oligosaccharide engineering combined with bioorthogonal reactions is providing unique opportunities to detect, image, and isolate glycoconjugates of living cells, tissues, and model organisms. In this methodology, exogenously-supplied non-natural sugars are fed to cells and employed by the biosynthetic machinery for the biosynthesis of neoglycoconjugates. In this way, reactive functional groups such as ketones, azides, and thiols have been incorporated into sialic acid, galactosamine, glucosamine, and fucose moieties of glycoconjugates. A range of bioorthogonal reactions have been described that functionalize the chemical ‘tags’ for imaging, isolation, and drug delivery.</jats:p
MassIVE MSV000090864 - Supporting information for Sialic acid O-acetylation patterns and glycosidic linkage type by IM-MS
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