8 research outputs found
Analysis on the General Conception and Planning of the Road Trip Campsite along the Land Silk Road in China
No full textThis article is based on the cultural background of the land section of the "Silk Road" and the surrounding status quo research basis, combined with its own characteristics of tourism resources, folk culture and traffic conditions, establish a self-driving camping site system in the five provinces of Shaanxi, Gansu, Ningxia, Qinghai and New Zealand on the domestic section of the "Silk Road". This paper summarizes the current situation and constraints of campsites in each province through data collection, data analysis and field investigation. On this basis, we put forward the overall construction and planning ideas of the camp. The purpose is to scientifically, reasonably and orderly plan the construction scheme of road trip routes, camping sites and campsites along the Silk Road.This will further promote the healthy development of tourism and cultural experience in the areas along the Silk Road, provide convenient and safe travel routes and recreation environment for tourists, but also improve the economy and people's living standards in the areas along the route
An Ecological Study on A Sand County Almanac
No full textAldo Leopold is an American author, scientist, ecologist, conservationist, environmentalist, whose most outstanding and representative work A Sand County Almanac is filled with abundant and deep ecological thoughts. This paper intends to explore Leopold’s ecological thoughts in this book. First, Leopold redefines the relationship between nature and human beings. He states that human beings are part of nature and should show love and respect for it; second, Leopold proposes the famous and significant land ethic theory, which establishes a basis for new ecological ethics. He enlarges the ethic range to land and to the whole nature, sets the criteria of land ethic, and describes the importance of ecological conscience which is fundamentally helpful to solve ecological crisis and protect the ecosystem; third, Leopold elaborates on the values of wilderness, such as the recreational value,the ecological value, the aesthetic value, the scientific value, the ecological value and the cultural value.Nowadays, all these ecological thoughts are still meaningful for people to know and love the nature, to protect the land and the wilderness
An Ecological Study on A Sand County Almanac
No full textAldo Leopold is an American author, scientist, ecologist, conservationist, environmentalist, whose most outstanding and representative work A Sand County Almanac is filled with abundant and deep ecological thoughts. This paper intends to explore Leopold’s ecological thoughts in this book. First, Leopold redefines the relationship between nature and human beings. He states that human beings are part of nature and should show love and respect for it; second, Leopold proposes the famous and significant land ethic theory, which establishes a basis for new ecological ethics. He enlarges the ethic range to land and to the whole nature, sets the criteria of land ethic, and describes the importance of ecological conscience which is fundamentally helpful to solve ecological crisis and protect the ecosystem; third, Leopold elaborates on the values of wilderness, such as the recreational value,the ecological value, the aesthetic value, the scientific value, the ecological value and the cultural value.Nowadays, all these ecological thoughts are still meaningful for people to know and love the nature, to protect the land and the wilderness.</jats:p
Liquid–Liquid Equilibrium Study for the Ternary System of Water + Acetic Acid + 2-Octanol
No full text
Primer-introduced restriction analysis polymerase chain reaction method for non-invasive prenatal testing of β-Thalassemia
No full textRare Loss-of-Function Variants in NPC1 Predispose to Human Obesity
No full textSome Shanghai Clinical Center f a role of Niemann-Pick type C1 (NPC1) for obesity traits. However, whether the loss-of-function mutations in NPC1 cause adiposity in humans remains unknown. We recruited 25 probands with rare autosomal-recessive Niemann-Pick type C (NP-C) disease and their parents in assessment of the effect of heterozygous NPC1 mutations on adiposity. We found that male NPC1(+/-) carriers had a significantly higher BMI than matched control subjects or the whole population-based control subjects. Consistently, male NPC1(+/-) mice had increased fat storage while eating a high-fat diet. We further conducted an in-depth assessment of rare variants in the NPC1 gene in young, severely obese subjects and lean control subjects and identified 17 rare nonsynonymous/frameshift variants in NPC1 (minor allele frequency < 1%) that were significantly associated with an increased risk of obesity 3.40% vs. 0.73%, respectively, in obese patients and control subjects, P = 0.0008, odds ratio = 4.8, 95% CI 1.7-13.2), indicating that rare NPC1 variants were enriched in young, morbidly obese Chinese subjects. Importantly, participants carrying rare variants with severely damaged cholesterol-transporting ability had more fat accumulation than those with mild/no damage rare variants. In summary, rare loss-of-function NPC1 mutations were identified as being associated with human adiposity with a high penetrance, providing potential therapeutic interventions for obesity in addition to the role of NPC1 in the familial NP-C disease.National Natural Science Foundation of China [81522011, 81570757, 81570758, 81370963, 81370949]; National International Science Cooperation Foundation [2015DFA30560]; National Basic Research Program of China [2015CB553601]; Foundation for Innovative Research Groups of the National Natural Science Foundation of China [81621061]; Shanghai Sailing Program [16YF1409800]; Brown University Endowment for Brazil and China Initiatives; American Heart Association; National Heart, Lung, and Blood Institute; National Institute of Diabetes and Digestive and Kidney Diseases in the U.S.SCI(E)ARTICLE4935-9476
