20 research outputs found
Mrs. William Dennison (Ann Elizabeth Dennison (Neil), between 1860 and 1869
No full textWritten on verso: Mrs. William Dennison (Ann Eliza Neil Dennison).
PH Coll 1323.6To order a reproduction, inquire about permissions, or for information about prices see: http://www.lib.washington.edu/specialcollections/services/reproduction/reproduction Please cite the Order Numbe
Iscrizioni esposte in contesti di reimpiego: l'esempio veneziano
No full textL'articolo indaga gli ambiti di applicazione della nozione di «scrittura esposta», inizialmente elaborata da Armando Petrucci e solitamente applicata ai contesti originari per i quali le iscrizioni furono concepite. Attraverso un'esemplificazione diacronica di spolia epigrafici provenienti da Venezia e dalle isole della laguna circostante, l'autore si interroga sulle motivazioni del riutilizzo delle iscrizioni antiche, nonché sugli esiti di tale fenomeno. In particolare, sono notevoli i casi in cui la scrittura esposta delle iscrizioni reimpiegate generò nuova scrittura esposta, mentre in altre circostanze la scrittura fu deliberatamente nascosta, dimostrando così lo scopo puramente funzionale di quei reimpieghi.This article investigates the notion of «exhibited writing» («scrittura esposta»), first propounded by Armando Petrucci and usually applied to the original contexts for which inscriptions were conceived. Building on a cross-temporal selection of epigraphic spolia from Venice and the islands of the nearby lagoon, the author explores the motives for reusing ancient inscriptions, as well as the results of this phenomenon. Especially noteworthy are the cases when the exhibited writing of reused inscriptions generated new exhibited writing, while in other circumstances writing was deliberately hidden, thus showing that those spolia were only useful as structural elements
La Tomba Galeassi di Palestrina
No full textMore than one hundred and fifty years after the discovery of the Galeassi Tomb at Palestrina, this volume presents a new comprehensive study. This is one of the most important tombs of the Orientalising period in Latium vetus. The analysis of the documents published by Raffaele Garrucci
and of archive documents allows us to specify the date of the excavation: October 1863, and not 1861, as is often said. The objects found were sold in 1865 (before the 27th March), some to Mr. Castellani and some to Mr. Milani. It is argued that we can identify Mr. Milani with Giovan Battista Milani, mentioned in the list of Roman Jewellers , together with Fortunato Pio Castellani. The objects found in the Galeassi Tomb entered the Castellani Collection, and they are now divided between the British Museum in London, where they arrived in 1872 with the acquisition of the Collection of Alessandro Castellani, and the Villa Giulia Museum in Rome, where they arrived in 1926 with the acquisition of the Collection of Augusto Castellani. The part sold to Mr. Milani is, unfortunately, impossible to find. The Galeassi Tomb was discovered in the Galeassi vineyard, located behind the church of San Rocco, along a side road off the Via Labicana - or
road to Rome - and the Via della Marcigliana. It is now in an area close to Via Fratelli Bandiera at Palestrina. The name of the owner of the Galeassi property was from an early point confused with General Vincenzo Galassi, author of the discovery together with the Archpriest Alessandro Regolini of the famous tomb in the necropolis of Sorbo in Cerveteri. This confusion coupled with the presence of the same iconographic motifs on the jewelry of the two tombs has unfortunately caused the objects from the Galeassi Tomb at Palestrina to be attributed erroneously to the Regolini - Galassi Tomb in Cerveteri. This volume corrects as far as possible these methodological errors. The tomb is of a type called sepolti sotti i sassi (buried under the stones) which means that it was not a chamber tomb with a multiplicity of burials. The continuity of use of the Colombella necropolis, from the half of the eighth century B.C. until the late Republican age, will have favored contiguous burials and, in some cases, overlapping graves. Therefore, it seems reasonable to think that there were at least four female burials (contexts A1, A2, B, C), dating from the end of the eighth to the end of the sixth – early fifth century B. C. Nearly all of the objects found, which consist almost exclusively of jewelry, were produced at Cerveteri, while others are probably local productions that show close contacts with others found in Latium vetus and in the Picene region. The study of archive documents and objects highlights the sophistication and wealth of the Praenestine élite
Bench-to-bedside review: Erythropoietin and its derivatives as therapies in critical care
No full textAuthor can archive publisher's pdf. Free via Creative Commons: CC-BENCHTOBEDSIDE-2.0. © 2012 BioMed Central Ltd
Gli Asolani
No full textPrinting -- Page design (Title page)
Printers and publishers -- Marks and colophons (Title page)[24], 227, [1] p. ; 15 cm. (12mo)Letterpress on handmade laid paperWoodcutsBound in contemporary stiffened vellum, sewn on two vegetal cords.
Headbands sewn on vellum thongs.
All edges stained blue.
Author and title calligraphed on spine.Signatures: *[superscript 12] A-I[superscript 12] K[superscript 6] [$6(-K4,5,6)signed]; 126 leaves, pp. [24] 1-105 [106] 107-227 [228] [misnumbering 44 as 34, 50 as 70, 119 as 11].
Woodcut printer's mark on t.p.
Head- and tailpieces and decorated initials.
Includes register.John L. Lievsa
Semiótica de una práctica cultural. Cuicuilco Revista de la Escuela Nacional de Antropología e Historia: Análisis del discurso y semiótica de la cultura: perspectivas analíticas para el tercer milenio Tomo II. Num. 25 (2002) Vol. 9 mayo-agosto
No full textDesde la semiótica, los fenómenos culturales guardan una memoria colectiva. En palabras de Iuri Lotman [1994] esta memoria "conforma un mecanismo supraindividual de conservación y transmisión de ciertos comunicados (textos) y de elaboración de otros nuevos". El tatuaje como texto semiótico puede ser analizado: 1) como marca estática, el tatuaje-texto permanece inmóvil y perenne; 2) como marca dinámica, donde la lectura que se hace de este signo puede variar o se mantiene.The cultural phenomena, from the point of view of the semiothic, have a collective memory. In Iuri Lotman words [1994] this memory makes an individual mecanism of preservation and transmition of meaningsand transmition and newones. The tatoo like a semiothic text, could be analyzed: 1) As static marc, the tatoo (text) remaines without muvement forever; 2) the tatoo as a dinamic marc, wich can change o remaines.Alvarez, Nelson E.. 1998 “Las Islas Marías y la subcultura carcelaria”, en Boletín Mexicano de Derecho Comparado, núm. 91, enero-abril, México, UNAM, Instituto de Investigaciones Jurídicas.Axelrod, R.. 1986 La evolución de la cooperación, Madrid, Alianza Universidad.Bourdieu, Pierre. 1991 El sentido práctico, Madrid, Taurus Ediciones.Casanova y Prets, Pelayo. 1937 Antropología jurídica, La Habana.Cola Alberich, Julio. 1949 Amuletos y tatuajes marroquíes, Madrid, Consejo Superior de Investigaciones Científicas, Instituto de Estudios Africanos.Montaner y Simón (eds.). 1922 Costumbres del universo; narración popular de las costumbres, ceremonias, ritos y supersticiones de todos los países, 2 tomos, Barcelona, Montaner y Simón Editores.Di Tullio, Benigno. s/f Principios de Criminología clínica y Psiquiatría forense, Madrid, Aguilar.Domalain, Jean-Yves. 1973 Pemjamon entre los salvajes de Borneo, Barcelona, Noguer.Donderis Torrens, Carlos. 1964 Estudio médico-legal del tatuaje, tesis doctoral, Valencia.Font Riera, Gabriel. 1992 Tatuaje y delincuencia, resumen de tesis presentada para aspirar al grado de doctor en medicina, Barcelona.García, José Luis. 1992 “El uso del espacio: conductas y discursos”, en J. A. Glez Alcantud y M. Glez de Molina (eds.), La tierra: mitos, ritos y realidades, Barcelona, Anthropos.García Ramírez, Sergio. 1994 Manual de Prisiones, México, Porrúa.Goffman, Erving. 1992 Internados, Buenos Aires, Amorrortu editores.Jordi Sabater, I. et al.. 1992 Els Tatuatges Dels Fang de L’Àfrica Occidental; art, simbolisme i biología en una
manifestació artística poc coneguda, Barcelona, Ajuntament de Barcelona, Traballs del Museu Etnológic/1.López-Coira, Miguel. 1992 “Reclusos y guardianes; la prisión como contexto”, en Barroso, J. y Abrunhosa R. (eds.), Psicologia e intervencao social de justica, Porto, APPORT.Lotman, Iuri. 1994 “La memoria a la luz de la culturología”, en Criterios, núm. 31, La Habana, Cuba, pp. 1-6.Lotman, Iuri. 1998 La semiosfera II. Semiótica de la cultura, del texto de la conducta y del espacio. España, Frónesis, Cátedra, Universitat de Valencia.Lombroso, Cesare. 1886 “Biologia e psicologia del delinquente-nato”, en L ?uomo delinquente, “Parte III, Italia, Fratelli Bocca Editori.Lowie, Robert. 1936 Manuel D’ Anthropologie culturelle, París, Payot.Marchiori, Hilda. 1978 Personalidad del delincuente, México, Porrúa.Martínez Baca, Francisco. 1899 Los tatuajes un estudio psicológico y médico legal en delincuentes y militares, Puebla.Meton de Alencar, Neto y José Nava. 1966 Tatuagens e Desenhos Cicatriciais. Belo Horizonte, Brasil, Govêrno do Estado de Minas Gerais.Orellana-Wiarco, Octavio. 1993 Manual de Criminología, México, Porrúa.Simonini, C.. s/f Medicina Legal Judicial, Barcelona, Jims.Shalins, M.. 1977 La economía de la edad de piedra, Madrid, Akal.Virel, André (texto), Charles y Josette Lenaars (fotógrafos). 1980 Decorated Man, the human body as art, Nueva York, Harry N. Abrams, Inc., Publishers
Emilio Ghione and the Mask of Za La Mort
No full textThis study aims to examine the cultural impact of Emilio Ghione's Za La Mort films (1914-1924) on Italian culture. These films constitute a significant Italian combination of several early cinema genres and sub-genres, such as the apache film, the traces of which have almost entirely disappeared. More broadly, the changing interpretations of Za La Mort figure allow us to understand wider shifts in Italian and European popular culture.
The first chapter of the study considers the wealth of influences from European popular culture that Emilio Ghione merged into the apache films, such as the apache sub-culture in Paris. The second chapter of the study then reconstructs the Za La Mort filmography, most of which has now been lost, from film viewings and archival documents. The third chapter considers Emilio Ghione's Za La Mort novels and theatrical productions in the years 1922-1930, and Ghione's attempts to make Za La Mort a more Fascist and nationalistic figure. The fourth chapter considers the enduring figure of Za La Mort in Italian popular culture, especially in Raffaele Matarazzo's Fumeria D'Oppio and a 1940's fumetti series. The fifth chapter considers the audience reception of the Za La Mort films from the limited remaining evidence and, positioning the series between the Cinema of Attractions of the 1900s and the Classical Cinema of the mid-1920's, analyses how the Za La Mort films were constructed to please a predominantly working class audience that valued spectacular thrills and great acting performances over narrative consistency and stable characterisation.
This research re-establishes the importance of one of Italian cinema's most important film-makers of the silent period, and his enduring importance as a popular cultural figure in Italy
Increased angiogenic factor secretion by decidual natural killer cells from pregnancies with high uterine artery resistance alters trophoblast function.
No full textSTUDY QUESTION
Are the concentrations of factors secreted by decidual natural killer (dNK) cells from pregnancies at high risk of poor spiral artery remodelling different to those secreted from pregnancies at low risk?
SUMMARY ANSWER
Expression levels of PLGF, sIL-2R, endostatin and angiogenin were significantly increased by dNK cells from high-risk pregnancies, and angiogenin and endostatin were found to alter trophoblast function.
WHAT IS KNOWN ALREADY
During early pregnancy, maternal uterine spiral arteries are remodelled from small diameter, low-flow, high-resistance vessels into larger diameter, higher flow vessels, with low-resistance. This change is essential for the developing fetus to obtain sufficient oxygen and nutrients. dNK cells have been implicated in this process.
STUDY DESIGN, SIZE, DURATION
dNK cells were isolated from first trimester terminations of pregnancies (obtained with local ethical approval) screened for normal- or high-resistance index, indicative of cases least (21%) likely to have developed pre-eclampsia had the pregnancy not been terminated (n = 18 each group). Secreted factors and the effects of these on the trophoblast cell line, SGHPL-4, were assessed in vitro.
PARTICIPANTS/MATERIALS, SETTING, METHODS
A multiplex assay was used to assess dNK cell-secreted factors. SGHPL-4 cell functions were assessed using time-lapse microscopy, 3D invasion assays, endothelial-like tube formation ability and western blot analysis.
MAIN RESULTS AND THE ROLE OF CHANCE
The expression levels of PLGF (P < 0.01), sIL-2R (P < 0.01), endostatin (P < 0.05) and angiogenin (P < 0.05) were significantly increased by dNK cells from high-risk pregnancies. Endostatin significantly decreased SGHPL-4 invasion (P < 0.05), SGHPL-4 tube formation (P < 0.05) and SGHPL-4 Aktser473 phosphorylation (P < 0.05). Angiogenin significantly decreased SGHPL-4 invasion (P < 0.05), but increased SGHPL-4 tube formation (P < 0.01) and decreased SGHPL-4 Aktser473 phosphorylation (P < 0.05).
LIMITATIONS, REASONS FOR CAUTION
The culture of dNK cells and protein concentrations in vitro may not fully represent the in vivo situation. Although SGHPL-4 cells are extravillous trophoblast derived, further studies would be needed to confirm the roles of angiogenin and endostatin in vivo.
WIDER IMPLICATIONS OF THE FINDINGS
The altered expression of secreted factors of dNK cells may contribute to pregnancy disorders associated with poor spiral artery remodelling.
STUDY FUNDING/COMPETING INTEREST(S)
This study was supported by the Wellcome Trust (project reference 091550). R.F. was a recipient of a PhD studentship from the Division of Biomedical Sciences, St. George's, University of London. The authors have no conflict of interests
Preclinical efficacy of the synthetic retinoid ST1926 for treating adult T-cell leukemia-lymphoma
No full textAdult T-cell leukemia-lymphoma (ATL) is an aggressive neoplasm caused by human T-cell leukemia virus type 1 (HTLV-1). The HTLV-1 oncoprotein Tax plays an important role in ATL pathogenesis. ATL carries a poor prognosis due to chemotherapy resistance, stressing the need for alternative therapies. Here, we investigate the preclinical efficacy of the synthetic retinoid ST1926 in ATL and peripheral T-cell lymphomas. Clinically achievable concentrations of ST1926 induced a dramatic inhibition of cell proliferation in malignant T-cell lines and primary ATL cells with minimal effect on resting or activated normal lymphocytes. ST1926 induced apoptosis, DNA damage, and upregulation of p53 proteins in malignant T cells, whereas it caused an early downregulation of Tax proteins in HTLV-1-positive cells. In murine ATL, oral treatment with ST1926 prolonged survival and reduced leukemia cell infiltration, white blood cell counts, and spleenmass. In spleens of ST1926-treated animals, p53 and p21 proteins were upregulated, poly (ADP-ribose) polymerase was cleaved, and Tax transcripts were reduced. These results highlight the promising use of ST1926 as a targeted therapy for ATL.Ablain J, 2014, NAT MED, V20, P167, DOI 10.1038-nm.3441; BARGONETTI J, 1992, GENE DEV, V6, P1886, DOI 10.1101-gad.6.10.1886; Baydoun HH, 2012, PLOS ONE, V7, DOI 10.1371-journal.pone.0042226; Bazarbachi A, 2010, J CLIN ONCOL, V28, P4177, DOI 10.1200-JCO.2010.28.0669; Bazarbachi A, 1999, BLOOD, V93, P278; Bazarbachi A, 2004, LANCET ONCOL, V5, P664, DOI 10.1016-S1470-2045(04)01608-0; Bazarbachi A, 1996, J ACQ IMMUN DEF SYND, V13, pS186, DOI 10.1097-00042560-199600001-00028; Bazarbachi A, 2011, BLOOD, V118, P1736, DOI 10.1182-blood-2011-03-345702; Bernard BA, 1992, BIOCH BIOPHYS RES CO, V186; Bitar N, 2009, TRANSFUSION, V49, P1859, DOI 10.1111-j.1537-2995.2009.02223.x; CHENG J, 1990, MOL CELL BIOL, V10, P5502; Cincinelli R, 2003, J MED CHEM, V46; Darwiche N, 2001, Hematol J, V2, P127, DOI 10.1038-sj.thj.6200098; Darwiche N, 2004, LEUKEMIA, V18, P607, DOI 10.1038-sj.leu.2403245; Dbaibo GS, 1998, J CLIN INVEST, V102, P329, DOI 10.1172-JCI1180; de The H, 1996, FASEB J, V10, P955; Degos L, 2001, ONCOGENE, V20, P7140, DOI 10.1038-sj.onc.1204763; El Hajj H, 2010, J EXP MED, V207, P2785, DOI 10.1084-jem.20101095; El-Sabban ME, 2000, BLOOD, V96, P2849; Fenaux P, 1999, BLOOD, V94, P1192; Fontana JA, 2002, LEUKEMIA, V16, P463, DOI 10.1038-sj-leu-2402414; Fratelli M, 2013, EUR J CANCER, V49, P1491, DOI 10.1016-j.ejca.2012.11.013; Gallo RC, 2011, BEST PRACT RES CL HA, V24, P559, DOI 10.1016-j.beha.2011.09.012; Garattini E, 2004, BLOOD, V103, P194, DOI 10.1182-blood-2003-05-1577; GILL PS, 1995, NEW ENGL J MED, V332, P1744, DOI 10.1056-NEJM199506293322603; Hall AP, 1998, J PATHOL, V186, P209; Hasegawa H, 2006, NAT MED, V12, P466, DOI 10.1038-nm1389; HERMINE O, 1995, NEW ENGL J MED, V332, P1749, DOI 10.1056-NEJM199506293322604; Hermine O, 1998, BIODRUGS, V10, P447, DOI 10.2165-00063030-199810060-00003; Kchour G, 2009, BLOOD, V113, P6528, DOI 10.1182-blood-2009-03-211821; Kfoury Y, 2005, CELL DEATH DIFFER, V12, P871, DOI 10.1038-sj.cdd.4401624; Maeda Y, 1996, BLOOD, V88, P4726; Maeda Y, 2008, J CANCER RES CLIN, V134, P673, DOI 10.1007-s00432-007-0334-6; Mahieux R, 2000, J VIROL, V74, P6866, DOI 10.1128-JVI.74.15.6866-6874.2000; Mahieux R, 2013, FRONT MICROBIOL, V4, DOI 10.3389-fmicb.2013.00156; Mahieux R, 2000, AIDS RES HUM RETROV, V16, P1677, DOI 10.1089-08892220050193137; Matsuoka M, 2007, NAT REV CANC, V7; Miyatake JI, 1997, LEUKEMIA, V11, P401, DOI 10.1038-sj.leu.2400593; Nakamura AJ, 2009, AGING-US, V1, P212; Nasr R, 2003, BLOOD, V101, P4576, DOI 10.1182-blood-2002-09-2986; Parrella E, 2006, MOL PHARMACOL, V70, P909, DOI 10.1124-mol.106.023614; Pisano C, 2007, ANN ONCOL, V18, P1500, DOI 10.1093-annonc-mdm195; Pise-Masison CA, 2000, MOL CELL BIOL, V20, P3377, DOI 10.1128-MCB.20.10.3377-3386.2000; Sala F, 2009, J CHROMATOGR B, V877, P3118, DOI 10.1016-j.jchromb.2009.08.001; Satou Y, 2006, P NATL ACAD SCI USA, V103, P720, DOI 10.1073-pnas.0507631103; Tsukasaki K, 2009, J CLIN ONCOL, V27, P453, DOI 10.1200-JCO.2008.18.2428; Valli C, 2008, MOL CANCER THER, V7, P2941, DOI 10.1158-1535-7163.MCT-08-0419; Wang Q, 2013, PLOS ONE, V8, DOI 10.1371-journal.pone.0082363; Yu T, 2006, DNA REPAIR, V5, P935, DOI 10.1016-j.dnarep.2006.05.040; Zhao TJ, 2014, ARCH VIROL, V159, P1849, DOI 10.1007-s00705-014-2099-y; Zuco V, 2005, NEOPLASIA, V7, P667, DOI 10.1593-neo.0512711
Morphological and micro-morphological comparative study of Genista etnensis populations.
No full textIn the framework of the studies carried out on the genus Genista L. (Fabaceae) in the Mediterranean area, the populations currently attributed to Genista etnensis (Raf.) DC. have been investigated. Our investigations are based on taxonomical, karyological, molecular, phylogenetic, lhytogeographical data. This species, originally described from Mt. Etna (Sicily) by Rafinesque (1814) as Spartium etnensis, was later attributed by De Candolle (1825) to the genus Genista. Other authors, such as Presl (1845), included it into another genus, named Drymospartum,while Spach (1845) separated this species from the genus Genista, referring it to Dendrospartum. Basing on literature, this species is often reported as described by Bivona Bernardi (1814), but in the protologue he quotes Rafinesque as author of this species, mentioning also the bibliographic data. As concerns its taxonomical position, G. aetnensis was included by Valsecchi (1993) within G. sect. Aureospartum belonging to the subgen.
Spartocarpus Spach. This is also supported by the molecular analyses carried out by De Castro et al. (2002) and Pardo et al. (2004), where the surveyed populations of G. etnensis are falling in a distinct subclade of the Genista clade. Therefore, despite its phylogenetic isolation and several autapomorphies, G. etnensis cannot be recognized as an independent genus, as already observed by De Castro et al. (2002). Also from the karyological viewpoint,the G. etnensis populations show an unusual chromosome complement (2n = 52) for genus Genista (Forrissier
1973, Cusma Velari et al. 2011). Genista etnensis occurs in Sicily (exclusively on Mt. Etna), Sardinia (Mt. Limbara, Monti di Alà, Supramontes, Golfo di Orosei, Gennargentu, Sette Fratelli, Monte Lattias, Is Cannoneris), Corsica (in three stands). Besides, it has been introduced into Campania (southern Italy), where it now occurs as an invasive alien in Ischia island, the Sorrentine Peninsula and especially on the Vesuvius. According to Agostini
(1959), the population of the latter locality originated from introduced plants after the eruption of 1906.
In-depth morphological investigations focused on the flowers and pods of living specimens allowed to highlight that the populations occurring in these territories are well differentiated, especially in the shape and size of the floral pieces, pods and seeds. In particular, the size of the flowers of the Sicilian populations is very similar to the Sardinian ones, but they differ in their shape. The Corsican populations are characterised by very small flowers,while the Vesuvian populations show flowers much bigger than the others. Calyces are clearly differentiated for their size, but also for the shape of the dorsal and ventral lips. In particular, teeth of the ventral lip are very small in the Sicilian populations, while they are more developed in the other populations, especially in the Sardinian ones. Anthers are longer in the Sicilian and Vesuvian populations, while they are much shorter in the Cyrno-Sardinian ones. Furthermore, pods and seeds coming from the Vesuvius are bigger than the others; those from Sicily are slightly smaller, while those from Sardinia and Corsica show a definitely smaller size. Finally, pod color of the Sicilian populations is usually blackish, while in the others it is always pale brown. Computerised image analysis on germplasm confirms this differentiation.
Significant differences were also observed in the micro-sculptures of the seed testa of the investigated populations. Besides, Rizzi Longo & Feoli Chiapella (1994) emphasized that the Sicilian and Sardinian populations show relevant differences in the micro-morphology of pollen grains.
Presl (1845), while examining the Sardinian populations of G. etnensis, had previously observed many morphological differences with the Sicilian ones, and he described them as Drymospartum sardum (= Genista etnensis Moris, non DC.). A similar opinion was expressed by Walpers (1848), who coined the name Dendrospartum sardoum Spach nom. nud., considering G. etnensis Moris as its synonym.
As for the taxonomic treatment of the populations of G. etnensis s.l., further detailed phylogenetic and taxonomic investigations are needed for clarifying this issue
