16 research outputs found
禮記
No full text孔穎達疏.綫裝.匡17.9 x 12.5 公分, 9行21字, 小字雙行同, 白口, 無魚尾, 左右雙邊, 版心下刻"汲古閣".Xian zhuang.Kuang 17.9 x 12.5 gong fen, 9 hang 21 zi, xiao zi shuang hang tong, bai kou, wu yu wei, zuo you shuang bian, ban xin xia ke"ji gu ge".Kong Yingda shu
書經
No full text孔頴達疏.綫裝.匡17.9 x 12.5 公分, 9行21字, 小字雙行同, 白口, 無魚尾, 左右雙邊, 版心下刻"汲古閣".Xian zhuang.Kuang 17.9 x 12.5 gong fen, 9 hang 21 zi, xiao zi shuang hang tong, bai kou, wu yu wei, zuo you shuang bian, ban xin xia ke "Ji gu ge".Kong Yingda shu
詩經
No full text孔頴達疏.綫裝.框17.9 x 12.5 公分, 9行21字, 小字雙行同, 白口, 無魚尾, 左右雙邊, 版心下刻"汲古閣".Xian zhuang.Kuang 17.9 x 12.5 gong fen, 9 hang 21 zi, xiao zi shuang hang tong, bai kou, wu yu wei, zuo you shuang bian, ban xin xia ke "Ji gu ge".Kong Yingda shu
Chun qiu Zuo zhuan zhu shu: [60 juan]. v.92
No full text杜氏[預]註 ; 孔頴達疏.綫裝.框17.9 x 12.5 公分, 9行21字, 小字雙行同, 白口, 無魚尾, 左右雙邊, 版心下刻"汲古閣".Xian zhuang.Kuang 17.9 x 12.5 gong fen, 9 hang 21 zi, xiao zi shuang hang tong, bai kou, wu yu wei, zuo you shuang bian, ban xin xia ke"ji gu ge".Du shi [Yu] zhu ; Kong Yingda shu
易經
No full text王弼, 韓康伯注 ; 孔頴達正義.綫裝.《周易兼義》卷一至六卷端題"魏王弼注 ; 唐孔穎達正義", 卷七至九題"晉韓康伯注 ; 唐孔穎達正義".匡17.9 x 12.5 公分, 9行21字, 小字雙行同, 白口, 無魚尾, 左右雙邊, 版心下刻"汲古閣".附: 陸德明釋文, 王弼周易畧例.Xian zhuang."Zhou yi jian yi" juan yi zhi liu juan duan ti "Wei Wang Bi zhu ; Tang Kong Yingda zheng yi", juan qi zhi jiu ti "Jin Han Kangbo zhu ; qi Tang Kong Yingda zheng yi".Kuang 17.9 x 12.5 gong fen, 9 hang 21 zi, xiao zi shuang xing tong, bai kou, wu yu wei, zuo you shuang bian, ban xin xia ke "Ji gu ge".Fu: Lu Deming shi wen, Wang Bi Zhou yi lü li.Wang Bi, Han Kangbo zhu ; Kong Yingda zheng yi
An 'Offline' Virtual Community: To Design a Public Condenser as a 'System'
No full textThe virtual world, existing in parallel with the physical one, has reshaped our life. Nowadays as people rely increasingly on social media for mutal interactions, ‘the virtual community actually becomes the real form of community today’ (Clark, A.). Such reliance owes to the ‘customizing system with hirarchy’ of virtual community to a large extent. This situation is especially dominant on the site of Morgestond, Den Haag: a generic post war city where most migrants lives. Having rarely any leading culture or shared memory, the community struggled to establish a commen sense of belonging. However, if taking the architecture as a ‘system’, it has the capability to learn from virtual community. With a translational process, the ‘customizing system’ of virtual community was first diagrammized, then spatialized and materialized as an architecture. The building is expected to guide its various users layer by layer, to their own favorite ‘channel’, and help them establish a sense of belonging to their community
K'ung Ying-ta (Kong Yingda), 574-648
No full textA descendant of Confucius in the thirty-second degree, and a distinguished scholar and public functionary. He wrote a commentary on the Canon of Changes, and was also the reputed author of the ti chi (diji) and lieh chuan (liejuan) sections of the History of the Sui dynasty
Sparse grid discontinuous Galerkin methods for the Vlasov-Maxwell system
No full text© 2019 The Author(s) cc-byIn this paper, we develop sparse grid discontinuous Galerkin (DG) schemes for the Vlasov-Maxwell (VM) equations. The VM system is a fundamental kinetic model in plasma physics, and its numerical computations are quite demanding, due to its intrinsic high-dimensionality and the need to retain many properties of the physical solutions. To break the curse of dimensionality, we consider the sparse grid DG methods that were recently developed in [20,21] for transport equations. Such methods are based on multiwavelets on tensorized nested grids and can significantly reduce the numbers of degrees of freedom. We formulate two versions of the schemes: sparse grid DG and adaptive sparse grid DG methods for the VM system. Their key properties and implementation details are discussed. Accuracy and robustness are demonstrated by numerical tests, with emphasis on comparison of the performance of the two methods, as well as with their full grid counterparts
Benchmarking Molecular Dynamics Force Fields for All-Atom Simulations of Biological Condensates
No full textProteins containing intrinsically
disordered regions
are integral
parts of the cellular signaling pathways and common components of
biological condensates. Point mutations in the protein sequence, genetic
at birth or acquired through aging, can alter the properties of the
condensates, marking the onset of neurodegenerative diseases such
as ALS and dementia. While the all-atom molecular dynamics method
can, in principle, elucidate the conformational changes that arise
from point mutations, the applications of this method to protein condensate
systems is conditioned upon the availability of molecular force fields
that can accurately describe both structured and disordered regions
of such proteins. Using the special-purpose Anton 2 supercomputer,
we benchmarked the efficacy of nine presently available molecular
force fields in describing the structure and dynamics of a Fused in
sarcoma (FUS) protein. Five-microsecond simulations of the full-length
FUS protein characterized the effect of the force field on the global
conformation of the protein, self-interactions among its side chains,
solvent accessible surface area, and the diffusion constant. Using
the results of dynamic light scattering as a benchmark for the FUS
radius of gyration, we identified several force fields that produced
FUS conformations within the experimental range. Next, we used these
force fields to perform ten-microsecond simulations of two structured
RNA binding domains of FUS bound to their respective RNA targets,
finding the choice of the force field to affect stability of the RNA–FUS
complex. Taken together, our data suggest that a combination of protein
and RNA force fields sharing a common four-point water model provides
an optimal description of proteins containing both disordered and
structured regions and RNA–protein interactions. To make simulations
of such systems available beyond the Anton 2 machines, we describe
and validate implementation of the best performing force fields in
a publicly available molecular dynamics program NAMD. Our NAMD implementation
enables simulations of large (tens of millions of atoms) biological
condensate systems and makes such simulations accessible to a broader
scientific community
ATP hydrolysis kinetics and thermodynamics as determinants of calcium oscillation in pancreatic β cells
No full textCellular ATP plays an important role in the calcium oscillation signal transduction pathway of pancreatic β cells. It triggers oscillation by binding the ATP-sensitive K^{+} channels (K_{ATP}), and maintains the oscillation by providing ATP hydrolysis free energy for the normal function of ion pumps on the plasma membrane. To reveal how cellular ATP level and ATP hydrolysis free energy affect calcium oscillation, we first constructed a simplified kinetic model of K_{ATP} and calcium pumps, then analyzed their thermodynamic characteristics. Bifurcation of calcium oscillation is determined by both cellular ATP concentration and ATP hydrolysis free energy such that an insufficient ATP energy supply would result in dysfunctional calcium oscillation. Second, to investigate the glucose sensing in β cells, we developed a glycolysis-calcium model that considers the dynamics of ATP and free energy levels. The model simulated three calcium patterns in wild type cells and impaired calcium response of K_{ATP} mutant cells, allowing the use of the ATP-free energy phase plane to explore the underlying mechanism. Our results reveal the thermodynamics of calcium oscillation and provide a framework for understanding the thermodynamics of other ion transport systems
