23 research outputs found
A metallurgical study of Nāga Bhasma
No full textBackground: The metal Nāga (Lead) is being used by Indians since ancient times. Its external and internal uses have been described in Caraka, Suśruta and other Ayurvedic Saṃhitā. According to most of the Rasa texts, Nāga Bhasma and its formulations are used in many diseases such as Prameha, Jvara, Gulma, Śukrameha etc. Objectives: In the present study, Nāga Bhasma was prepared by the traditional Puṭa method (TPM) and by the electric muffle furnace Puṭa method (EMFPM) and standardized using Metallographic studies. Doing so helps in the study of the microstructure of Nāga Bhasma and also helps in the identification of the metal particles along with the nature of compound formed during the Māraṇa (Bhasmīkaraṇa) process. Setting and Design: Different samples from initial raw material to final product of Nāga Bhasma were collected during the pharmaceutical process (1st, 30th and 60th Puṭa) from both methods i.e. TPM and EMFPM. Samples from both methods were studied using metallographic examination. Materials and Methods: The processing of the Nāga Bhasma (ṣaṣṭipuṭa) was done according to Ānanda Kanda[9] Samples from the raw material i.e. Aśodhita Nāga (raw Lead) and that processed after 1st, 30th and 60th Puṭa from both methods i.e. traditional Puṭa method (using heat from burning of cow dung cakes) and electric muffle furnace Puṭa method were taken. They were mounted on self hardening acrylic base. After careful polishing to obtain scratch free surface of product, they were used for metallurgical study. Conclusion: This study shows that traditional Puṭa method may be better than electric muffle furnace Puṭa method because of more homogeneous distribution of Lead sulphide in the Nāga Bhasma which is prepared by traditional method
Ethnomedicinal, Toxicity and Pharmacological study of <i>Abrus precatorious</i>: A Critical Review
No full textPHYTOCHEMICAL STUDY OF ASHODHIT AND SHODHIT GUNJA (ABRUS PRECATORIUS) PERICARPS.
Get PDFObjective: The aim of the present research work was to carry out the effect of Shodhana on Gunja pericarps by using advanced analytical tools. It is attributable to the plant Abrus precatorius L. belonging to family fabaceae having three types of plants white, red and black seeds.Methods: Three varieties of Gunja seed\u27s pericarps were subjected for Swedana in cow\u27s milk and Kanji. The Shodhit and Ashodhit Gunja pericarps were subjected for analytical parameters. For the establishment of the effect of Shodhana, the percentage of total ash, acid insoluble ash, total protein and successive extractives were carried out on Ashodhita and Shodhita pericarps.Results: The study showed that the percentage of total ash was reduced in Shodhit samples as compared to Ashodhit samples. The percentage of hexane and chloroform extractives in milk Shodhit pericarps were increased in all the samples, however, no significant variations were observed in Kanji Shodhit samples. On the contrary, the percentage of alcohol and water extractives value decreased in Shodhit samples.Conclusion: It was found that most of the phytochemicals were decreased in Shodhit samples of Kanji as compared to cow milk
Comparative Pharmaceutical Study of White & Black Gunja (Abrus prectorius L.) Kernels
No full textAssessing the effects of Mucuna Pruriens in the treatment of Parkinson\u27s Disease: A Review
Get PDFMucuna pruriens (Mp) is one of the most widely used medicinal plants in Ayurveda, the traditional Indian system of medicine. Recognized for its high nutritional value, Mp has long been an important food source in Asia, the Americas, and various African countries. Additionally, it serves as a cover crop and animal fodder. Traditionally, Mp has been employed as an antivenom for snake bites. Research suggests that it possesses numerous beneficial properties, including anti-oxidative, anti-inflammatory, anti-epileptic, and anti-microbial activities. It is also commonly used as a potent aphrodisiac.Parkinson\u27s disease (PD) is a complex neurological disorder characterized by the gradual degeneration of dopaminergic neurons, leading to movement impairments such as resting tremors, rigidity, and bradykinesia. The anti-Parkinsonian potential of Mp has been investigated since the 19thcentury, with various studies highlighting its neuroprotective effects. Levodopa (L-DOPA), a key phytoconstituent of Mp, is primarily responsible for its anti-PD properties. Besides L-DOPA, other bioactive compounds present in Mp exhibit antioxidant and neuroprotective effects.This review explores the ethnomedicinal applications, phytochemistry, and anti-PD potential of Mp based on available literature, including preclinical studies and select clinical trials involving PD patients. Furthermore, it underscores the significance of Mp in PD management through a comprehensive analysis of existing research. These insights may contribute to the development of future therapeutic strategies for more effective PD treatment
Antioxidant and Neuroprotective Potential of Mastakam Yoga via HRMS Analysis: A study on Acorus calamus & Centella asiatica
Get PDFIntroduction: Globally, the prevalence of neurodegenerative disorders like Dementia, Parkinson\u27s disease, and Alzheimer\u27s disease is increasing, highlighting the need for effective natural neuroprotective and antioxidant agents. In Ayurveda, herbs like Centella asiatica (Mandukparni) and Acorus calamus (Vacha) are well known for their neuroprotective and memory-boosting properties. In this study, a unique herbal formulation called Mastakam Yoga (MSY) was prepared with hydroalcoholic extracts of these two herbs in equal proportion. MSY is suggested to have synergistic antioxidant and neuroprotective benefits. The objective of this study is to discover bioactive components in Mastakam Yoga using High-Resolution Mass Spectrometry and assess their role in neuroprotective and antioxidant activities.
Materials and Methods: Mastakam Yoga (MSY) was formulated by combining an equal amount of hydroalcoholic extracts of Acorus calamus and Centella asiatica. The formulation was analysed using High-Resolution Mass Spectrometry (HRMS) for phytochemical profiling. The compounds were then examined through existing research to check for known antioxidant or neuroprotective qualities. Emphasis was placed on compounds known for antioxidant, anti-inflammatory, and neuroprotective effects.
Results: Several bioactive substances, including kynurenic acid, betaine, gabapentin, nootkatone, vanillin, and scopoletin, were found by HRMS analysis of Mastakam Yoga. These chemicals are linked to neuroprotective mechanisms that include oxidative stress inhibition, synaptic plasticity enhancement, and neuroinflammation control.
Discussion: The findings suggest that MSY has strong potential as a natural antioxidant and neuroprotective agent. However, further in vivo and clinical trials are essential to validate these findings and examine the potential therapeutic use of MSY in treating cognitive and neurodegenerative diseases
Challenges for application of realgar: A critical review
No full textRealgar has been not only well-known poisons but also used as healing agent. Realgar has long been used in traditional medicines for different diseases; so far arsenic can be extremely toxic and carcinogenic. In Ayurvedic and Chinese traditional medicines arsenic usually comes from conscious addition for healing purposes, mostly in the form of mineral arsenicals with orpiment (As2S3), realgar (As4S4), and arsenic trioxide (As2O3). Pharmacological studies revealed that realgar is effective against in different cancer cell line. However, it has been critically limited clinical applications because of its many disadvantages, for example, low solubility in water, high toxicity, poor gastrointestinal absorption, and bioavailability. This review evaluates the toxicology, bioaccessibility, and pharmacology of the realgar used in Ayurvedic and Chinese traditional medicines. In recent times, numerous types of realgar nanoparticles (NPs) have been developed due to insolubility of realgar in water and different media. Most of the NPs of realgar possess the exclusive optical qualities of quantum dots. The pharmacological activities and bioavailability of realgar NPs are much more partial by their sizes, building realgar an exciting biomedical and pharmaceutical research applicant
