1,720,964 research outputs found
OPTIMIZATION OF DOXORUBICINE INCORPORATION AND OF THE YIELD OF POLYBUTYLCYANACRYLATE NANOPARTICLES
No full textStatistical procedures for optimizing the freeze-drying of a model drug in ter-butyl alcohol:water mixtures
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Preparation and evaluation in vitro of colloidal lipospheres containing pilocarpine as ion pair
No full textAqueous dispersions of solid lipospheres containing up to 7.5% pilocarpine as lipophilic ion pairs were submitted to a preliminary evaluation. The lipospheres (diameter 75-85 nm) consisted mainly of stearic acid and egg lecithin; pilocarpine base was incorporated as ion pair with mono-octylphosphate, monodecylphosphate and monohexadecylphosphate. The following parameters were investigated: stability constants (β) and lipophilicity of the ion pairs, size, polydispersity and drug content of the lipospheres, pilocarpine release in vitro. The preparations might constitute a promising vehicle for sustained ocular delivery of pilocarpine
Ophthalmic preparations containing levobunolol as ion-pair: studies on "in vitro" corneal permeation and on "in vivo" hypotensive activity in albino rabbits
No full textDoxorubicine englobed in polybutylcyanoacrylate nanocapsules: behaviour in vitro and in vivo
No full textNanocapsules of polybutylcyanoacrylate containing doxorubicine were prepared from w/o microemulsion. A concentration of about 10 % of the drug was obtained. After washing, dispersion and lyophilization of the nanocapsules, some experiments were performed in vivo and in vitro. About 1 % of doxorubicine was released in vitro in 48 hours; after injection on the hairless back of rabbits, the nanoparticles without the drug gave any inflammatory processes, while the nanocapsules containing doxorubicine gave a deeper and more prolonged ulcer than that of the same amount of doxorubicine in solution, indicating that practically all the drug was inside the nanocapsules
Preparation and evaluation in vitro of solutions and o/w microemulsions containing levobunolol as ion-pair
No full textCholesteryl Butyrate in Solid Lipid Nanospheres as an Alternative Approach for Butyric Acid Delivery
No full textPertechnetate release from a water oil microemulsion and an aqueous-solution after subcutaneous injection in rabbits
No full textA water-oil microemulsion and an aqueous solution, both carrying pertechnetate, were injected subcutaneously in rabbits; release was observed by imaging the administration sites with a gamma-camera. Disappearance from the injection site of pertechnetate in aqueous solution was about ten times faster than that of pertechnetate in a microemulsion
Cholesteryl butyrate solid lipid nanoparticles inhibit adhesion of human neutrophils to endothelial cells
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