1,721,046 research outputs found
Intraocular pressure fluctuation and rates of visual field progression in primary open-angle glaucoma: an exploratory analysis from the United Kingdom Glaucoma Treatment Study (UKGTS)
No full textA comparison of nerve fibre layer measurements using optical coherence tomography and scanning laser polarimetry in normal and glaucomatous eyes
No full textPrimary open angle glaucoma patients have lower systemic mitochondrial function, associated with lower systemic nicotinamide adenine dinucleotide (NAD) levels, compared to Controls
No full text
Reduced systemic mitochondrial function is associated with faster rates of visual field progression in primary open angle glaucoma
No full textClinical assessment of stereoscopic optic disc photographs for glaucoma: the European Optic Disc Assessment Trial (EODAT)
No full textPurpose: To determine the diagnostic accuracy of judging optic disc photographs for glaucoma by ophthalmologists.
Design: Evaluation of diagnostic test and technology.
Participants: A total of 243 of 875 invited ophthalmologists in 11 European countries.
Methods: We determined how well each participant classified 40 healthy eyes and 48 glaucomatous eyes with
varying severity of the disease on stereoscopic slides. Duplicate slides were provided for determining intraobserver agreement. All eyes were also imaged with the GDx with variable corneal compensation (GDx-VCC) (Carl Zeiss Meditec AG, Jena, Germany) and the Heidelberg Retina Tomograph (HRT) I (Heidelberg Engineering GmbH, Heidel- berg, Germany). Diagnostic accuracies of clinicians were compared with those of the best machine classifiers.
Main Outcome Measures: Accuracy of classification, expressed as sensitivity, specificity, and overall accuracy. Intraobserver agreement (K).
Results: The overall diagnostic accuracy of ophthalmologists was 80.5% (standard deviation [SD], 6.8; range, 61.4%–94.3%). The machine classifiers outperformed most observers in diagnostic accuracy; the GDx-VCC nerve fiber indicator and the HRT’s best classifier correctly classified 93.2% and 89.8% of eyes, respectively. The intraobserver agreement (K) varied between -0.13 and 1.0 and was on average good (0.7).
Conclusions: In general, ophthalmologists classify optic disc photographs moderately well for detecting glaucoma. There is, however, large variability in diagnostic accuracy among and agreement within clinicians. Common imaging devices outperform most clinicians in classifying optic discs
Author Response: Passing–Bablok Regression Is Inappropriate for Assessing Association Between Structure and Function.
Full text linkDiagnosis of Primary Open Angle Glaucoma: the 10th Consensus Report of the World Glaucoma Association
No full textAccuracy of Matching Optic Discs with Visual Fields: The European Structure and Function Assessment Trial (ESAFAT).
No full textPURPOSE: To determine the ability of ophthalmologists across Europe to match stereoscopic optic disc photographs to visual fields of varying severity.
DESIGN: Evaluation and comparison of 2 diagnostic tests.
PARTICIPANTS: A total of 109 of 260 invited ophthalmologists in 11 European countries. These had participated in the previous European Optic Disc Assessment Trial (EODAT), a trial on glaucoma diagnostic accuracy based on optic discs only.
METHODS: Each participant matched stereo optic disc photographs of 40 healthy and 48 glaucomatous eyes to a visual field chosen from 4 options per disc. The 4 presented visual fields included the corresponding one and 3 other visual fields, varying in severity. The matching accuracy and any inaccuracy per disease severity were calculated. Classification accuracy (as glaucomatous or healthy) was compared with EODAT data. Duplicate slides allowed for the assessment of intraobserver agreement.
MAIN OUTCOME MEASURES: Accuracy of matching optic discs with their corresponding visual field and of classifying them as healthy or glaucomatous; intraobserver agreement (κ).
RESULTS: The overall accuracy of ophthalmologists for correctly matching stereoscopic optic disc photographs to their visual fields was 58.7%. When incorrectly matched, the observers generally overestimated the visual field severity (P < 0.001), notably in eyes with early glaucoma. The intraobserver agreement was, on average, moderate (0.52).
CONCLUSIONS: European ophthalmologists correctly matched stereoscopic optic disc photographs to their corresponding visual field in only approximately 59% of cases. In most mismatches, the clinicians overestimated the visual field damage
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