129,404 research outputs found

    [Letter from Representative Clyde L. Garrett to T. N. Carswell - April 8, 1940]

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    A letter written to Mr. T. N. Carswell, Abilene, Texas, from Clyde L. Garrett, House of Respresentatives, dated April 8, 1940. Garrett advises Carswell that he is soliciting his valued support and influence in the race for re-election to Congress

    [Letter from T. N. Carswell to Representative Clyde L. Garrett - May 14, 1938]

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    A letter written to the Honorable Clyde L. Garrett, House of Representatives, Washington, D. C. from T. N. Carswell, Sec.-Mgr. [Abilene Chamber of Commerce] dated May 14, 1938. Carswell advises Garrett that Leon Kendrick, 18, is desirous of entering the Merchant Marines. Carswell requests that Garrett send information to Kendrick regarding a school and the conditions of appointment

    [Herman Garrett Family]

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    Photograph of the Herman Garrett family from their family house at 611 N Big Spring Street, arranged in three rows on the house's porch. In the back row, from left to right: Lillian Garrett Reiger, Dora Garrett Rankin, Al H. Garrett, Elizabeth Garrett, Neta Garrett Wilson, and H. N. Garrett (came to Midland in 1882). Middle row (both seated on chairs, from left): Neta Wilson's mother-in-law and Mrs. Herman (Lucy Ann) Garrett. Front row (both seated on porch): Luther Wilson, Bess Garrett Holmes, and Mike Garrett

    Ray Garrett

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    Photo of Ray Garrett, a participant on a SOCOTWA river trip on the San Juan River in the 1950s or early 1960

    Mark Garrett

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    Photo of Mark Garrett, a participant on a SOCOTWA river trip on the San Juan River in the 1950s or early 1960

    Replication Data for: Measurement Error and the Specification of the Weights Matrix in Spatial Regression Models

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    While the spatial weights matrix W is at the core of spatial regression models, there is a scarcity of techniques for validating a given specification of W. I approach this problem from a measurement error perspective. When W is inflated by a constant, a predictable form of endogeneity occurs that is not problematic in other regression contexts. I use this insight to construct a theoretically appealing test and control for the validity of W that is tractable in panel data, which I call the K test. I demonstrate the utility of the test using Monte Carlo simulations

    Replication Data for: Measurement Error and the Specification of the Weights Matrix in Spatial Regression Models

    No full text
    While the spatial weights matrix W is at the core of spatial regression models, there is a scarcity of techniques for validating a given specification of W. I approach this problem from a measurement error perspective. When W is inflated by a constant, a predictable form of endogeneity occurs that is not problematic in other regression contexts. I use this insight to construct a theoretically appealing test and control for the validity of W that is tractable in panel data, which I call the K test. I demonstrate the utility of the test using Monte Carlo simulations

    Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings

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    Characterization of segmental flexibility is needed to understand the biological mechanisms of the very large category of functionally diverse proteins, exemplified by the regulators of complement activation, that consist of numerous compact modules or domains linked by short, potentially flexible, sequences of amino acid residues. The use of NMR-derived residual dipolar couplings (RDCs), in magnetically aligned media, to evaluate interdomain motion is established but only for two-domain proteins. We focused on the three N-terminal domains (called CCPs or SCRs) of the important complement regulator, human factor H (i.e., FH1-3). These domains cooperate to facilitate cleavage of the key complement activation-specific protein fragment, C3b, forming iC3b that no longer participates in the complement cascade. We refined a three-dimensional solution structure of recombinant FH1-3 based on nuclear Overhauser effects and RDCs. We then employed a rudimentary series of RDC data sets, collected in media containing magnetically aligned bicelles (disklike particles formed from phospholipids) under three different conditions, to estimate interdomain motions. This circumvents a requirement of previous approaches for technically difficult collection of five independent RDC data sets. More than 80% of conformers of this predominantly extended three-domain molecule exhibit flexions of &lt;40°. Such segmental flexibility (together with the local dynamics of the hypervariable loop within domain 3) could facilitate recognition of C3b via initial anchoring and eventual reorganization of modules to the conformation captured in the previously solved crystal structure of a C3b:FH1-4 complex.</p

    Rainbow Bridge, Ray Garrett

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    Photo of Ray Garrett, taken at Rainbow Bridge by Greg Dimmitt or David Thompson, during a SOCOTWA river trip on the Colorado River in the 1950s or early 1960
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