163,564 research outputs found
Using ecological and field survey data to establish a national list of the wild bee pollinators of crops
Get PDFMM was funded by grant INIA-RTA2013-00139-C03-01 (MINECO and FEDER)Hutchinson, L.A., Oliver, T.H., Breeze, T.D., Bailes, E.J., Brünjes, L., Campbell, A.J., Erhardt, A., de Groot, G.A., Földesi, R., García, D., Goulson, D., Hainaut, H., Hambäck, P.A., Holzschuh, A., Jauker, F., Klatt, B.K., Klein, A.-M., Kleijn, D., Kovács-Hostyánszki, A., Krimmer, E., McKerchar, M., Miñarro, M., Phillips, B.B., Potts, S.G., Pufal, G., Radzevičiūtė, R., Roberts, S.P.M., Samnegård, U., Schulze, J., Shaw, R.F., Tscharntke, T., Vereecken, N.J., Westbury, D.B., Westphal, C., Wietzke, A., Woodcock, B.A., Garratt, M.P.D
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Comprehensibility of UML-B - A Series of Controlled Experiments
No full textThis paper summarises two controlled experiments conducted on a model that integrates the use of semi-formal notation, the Unified Modelling Language (UML) and a formal notation, B. The experiments assessed the comprehensibility of the model, namely UML-B. The first experiment compared the comprehensibility of a UML-B model and a B model. In the second experiment, the model was compared with an Event-B model, a new generation of B. The experiments assessed the ability of the model to present information and to promote problem domain understanding. The measurement focused on the efficiency in performing the comprehension tasks. The experiments employed a cross-over design and were conducted on third-year and masters students. The results suggest that the integration of semi-formal and formal notations expedites the subjects’ comprehension tasks with accuracy even with limited hours of training
Homelessness in Oxford : risks and opportunities across housing and homeless transitions
Get PDFThis report presents initial findings from CSI’s Homelessness in Oxford project. The project was designed by Dr. Garratt and Dr. Flaherty to be the first systematic attempt to track and understand people’s transitions into and out of different experiences of homelessness in Oxford. The project also explored the roles played by statutory and non-statutory homelessness prevention and relief services in Oxford
Leptin and peroxisome proliferator activated receptor alpha: understanding their contribution towards normalising the programmed phenotype in the peripheral tissues of IUGR offspring
No full textIn a rat model of intrauterine growth restriction (IUGR) induced by maternal global undernutrition, adult offspring are obese with associated metabolic disturbances. These metabolic abnormalities are all augmented by feeding a high calorie postnatal diet and reversed by neonatal leptin treatment. Evidence is now accumulating which indicates that altered epigenetic regulation and gene expression may underpin the relationship between the early life environment and metabolic disturbances in adult life. Therefore, to determine the mechanism responsible for the alterations in energy balance in the IUGR rat, this study investigated the effect of maternal diet, neonatal leptin treatment and a postnatal high fat diet on the expression and DNA methylation of genes involved in energy balance in the liver and adipose tissue of adult offspring. These genes included the peroxisome proliferator activated receptors (PPARs) and their target genes; acyl-coA oxidase (AOX), carnitine palmitoyl transferase-1 (CPT-1) and lipoprotein lipase (LPL).Real time PCR indicated that the expression of several key genes involved in energy balance, including PPAR?, PPAR? and their target genes, was not altered by maternal diet or postnatal diet in the liver or adipose tissue of these offspring. However, in adipose tissue, neonatal leptin treatment resulted in an increase in the expression of most genes tested, including PPAR?, PPAR? and their target genes. The increased PPAR? and LPL would facilitate the uptake of fatty acids into the adipocyte, whilst the upregulation of PPAR? and its target genes AOX and CPT-1, not normally expressed in adipocytes, would direct fatty acids taken up towards the ?-oxidation pathway instead of storage. This would imply that the fat cell had transformed from a fat storing cell to a fat metabolising cell. Gene expression data therefore indicated that the phenotypic changes induced by neonatal leptin treatment, i.e. the reduced weight gain, could be due to increased expression of PPAR?, PPAR? and their target genes in adipose tissue: Furthermore, the effects of this are persistent, due to the specific period of leptin administration during neonatal development. There was, however, no evidence of altered DNA methylation in the promoter regions measured which could account for these persistent effects.To investigate mechanisms underlying the regulation of the PPAR? promoter by leptin, the rat PPAR? promoter was mapped, cloned and characterised. As part of this process, six alternatively spliced variants were identified; one from adipose tissue (P1), two from the liver (P2, P3), one from the heart (P4) and two from the kidney (P5, P6). These transcripts were found to differ in their 5’untranslated region due to tissue specific promoter usage and alternative transcription start sites. The liver and adipose specific promoters were cloned and characterised using a reporter gene strategy. They were shown to differ in their basal activity, response to known activators of transcription and to neonatal leptin treatment. The regulation of the PPAR? promoter by leptin was investigated and shown to function via a non-canonical mechanism requiring both signal transducer and activators of transcription (Stat3) and specificity protein-1 (Sp1), which act at a unique region of the liver specific P2 promoter. The adipose specific P1 promoter was shown to be unresponsive to leptin treatment. Furthermore, real time PCR with primers specific to the P1 and P2 PPAR? transcripts indicated that the increased PPAR? expression seen in leptin treated offspring was due to an increase in the P2 specific transcript, not the P1 transcript. This indicated that the neonatal leptin treatment facilitated a selective switch in promoter usage to increase the expression of PPAR? and its target genes in a tissue in which they are not normally expressed, thus inducing an altered metabolism within the adipocytes of these offspring
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
Mr. Melvin J. Collier, RWWL AUC, June 2011
No full textThis video is a conversation with Mr. Melvin J. Collier. Mr. Collier talks about his book, "From Mississippi to Africa: A Journey of Discovery". Daniel Le, AUC Woodruff Library, is the interviewer
A Tripartite Post-Recession Rebalancing
No full textIn this latest Advance & Rutgers Report, entitled “A Tripartite Post-Recession Rebalancing,” Dean James W. Hughes and Professor Joseph J. Seneca deliver an incisive assessment of the current market conditions and obstacles in the path of our economic recovery. They offer a statistical cautionary tale that the private and public sector need to hear and acknowledge in order for the economy to make continued progress.This report was published as Issue Paper Number 7, November 2011, in Advance & Rutgers Report
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