8,284 research outputs found

    AGenDA: gene prediction by cross-species sequence comparison

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    Taher L, Rinner O, Garg S, Sczyrba A, Morgenstern B. AGenDA: gene prediction by cross-species sequence comparison. Nucleic Acids Research. 2004;32(Web Server):W305-W308.Automatic gene prediction is one of the major challenges in computational sequence analysis. Traditional approaches to gene finding rely on statistical models derived from previously known genes. By contrast, a new class of comparative methods relies on comparing genomic sequences from evolutionary related organisms to each other. These methods are based on the concept of phylogenetic footprinting: they exploit the fact that functionally important regions in genomic sequences are usually more conserved than non-functional regions. We created a WWW-based software program for homology-based gene prediction at BiBiServ (Bielefeld Bioinformatics Server). Our tool takes pairs of evolutionary related genomic sequences as input data, e.g. from human and mouse. The server runs CHAOS and DIALIGN to create an alignment of the input sequences and subsequently searches for conserved splicing signals and start/stop codons near regions of local sequence conservation. Genes are predicted based on local homology information and splice signals. The server returns predicted genes together with a graphical representation of the underlying alignment. The program is available at http://bibiserv.TechFak.Uni-Bielefeld.DE/agenda/

    Quantified Data Automata on Skinny Trees: an Abstract Domain for Lists

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    Abstract. We propose a new approach to heap analysis through an ab-stract domain of automata, called automatic shapes. Automatic shapes are modeled after a particular version of quantified data automata on skinny trees (QSDAs), that allows to define universally quantified prop-erties of programs manipulating acyclic heaps with a single pointer field, including data-structures such singly-linked lists. To ensure convergence of the abstract fixed-point computation, we introduce a subclass of QSDAs called elastic QSDAs, which forms an abstract domain. We eval-uate our approach on several list manipulating programs and we show that the proposed domain is powerful enough to prove a large class of these programs correct.

    The vanishing author in computer-generated works: a critical analysis of recent Australian case law

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    Abstract The use of software is ubiquitous in the creation of many copyright works, yet the requirement in copyright law that every work have a human author who engages in independent intellectual effort means that its use may prevent copyright subsistence. Several recent Australian cases have refocused attention on authorship as an essential criterion of copyright subsistence, and these cases suggest that much computer-produced output may be authorless and thus lack copyright protection. This article, the first in a two-part series, analyses how each case deals with the question of authorship of computer-produced works and why the use of software diminishes copyright protection for a significant number of computer-generated works. The article critiques the application of conventional notions of human authorship developed in the pre-computer age to modern productions and suggests alternative approaches to authorship that satisfy both the major objectives of copyright policy and the need to adapt to the computer age. The article argues that, without a broader judicial approach to authorship of computer-generated works, Parliament must remedy the lacuna in protection for these ‘authorless’ works. Possible solutions for reform are suggested. In a forthcoming article, the author comprehensively examines those reform proposals

    Drumheller, AB

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    Notes - A history of the Ursaline order in Drumheller, AB from 1935 to 1985 (2 pages)Drumhelle

    Souvenir of Edmonton, AB

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    Booklet - Souvenir of Edmonton - The Capital City of Alberta. Collection of photographs in a green cover tied with string, Edmonton, AB (48 pages

    Ab initio pair potentials at metal-ceramic interfaces

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    A systematic approach is proposed to obtain the interfacial interatomic potentials. By inverting ab initio adhesive energy curves for the metal-MgO ceramic interfaces, We derive interfacial potentials between Ag and O2-, Ag and Mg2+, Al and O2-, Al and Mg2+. The interfacial potentials, obtained from this method, demonstrate general features of bondings between metal atoms and ceramic ions

    Perceptions of pre- and post-event impacts of PEI 2014 year-long celebrations

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    This study examines Canadian perceptions of pre- and post-event impacts of the PEI 2014 Celebrations using the 2013 and 2015 surveys of PEI residents and other Canadians conducted by the Centre for Tourism Research. Overall, results indicate that Canadians’ awareness of, knowledge about, and attitudes toward the 1864 Charlottetown Conference and the PEI 2014 Celebrations increased and positively changed over time. The research also suggests that event organizers and/or destination tourism managers need to put greater emphasis on the “socio-cultural aspects” of the event such as community participation and cultural identity, and make an effort to increase tourism volume and value in order to obtain strong support from residents and be successful

    Ultra-low-power, class-AB, CMOS four-quadrant current multiplier

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    A class-AB four-quadrant current multiplier constituted by a class-AB current amplifier and a current splitter which can handle input signals in excess of ten times the bias current is presented. The proposed circuit operation is based on the exponential characteristic of BJTs or subthreshold MOSFETs. The multiplier is designed using the latter devices and achieves very low power consumption. Simulation results show that from a 0.65 V supply, the proposed circuit consumes 12.4 nW static power while less than 30 dB total harmonic distortion is achieved for an input modulation index up to 10.Microelectronics & Computer EngineeringElectrical Engineering, Mathematics and Computer Scienc

    Records of Empire, Monarchy, or Nation? The Archival Heritage of the Habsburgs in East Central Europe

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    This contribution to Ab Imperio's forum on the archives of empires examines the history of central government archives in the Habsburg Monarchy of East Central Europe from the sixteenth through twentieth centuries. The court, financial, and military archives in the imperial capital at first only served official purposes, but by the nineteenth century also supported historical research. Later the provinces and emerging national states also developed archives and made them accessible to historians. The multinational empire dissolved in 1918 and its successor states competed for possession of the central archives. National archives were considered essential for the creation of national states and histories

    Osservazioni sopra un articolo inserito nella Biblioteca italiana nel quale si parla di due lettere del pre. ab. Gio. Battista Baizini sul musaico di Pompei.

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    Mode of access: Internet.Sloan candidateLibrary's c.2 bound in old green decorated boards; presentation inscription from the author on front pastedown.Library's c.1 bound with: Due lettere sopra il musaico di Pompei / del pre. ab. Gio. Battista Baizini (90-B31630 c.1
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