66 research outputs found
sj-docx-1-jcn-10.1177_08830738221085158 - Supplemental material for Spectrum of Movement Disorders Among Children With Subacute Sclerosing Panencephalitis: A Cross-Sectional Study
No full textSupplemental material, sj-docx-1-jcn-10.1177_08830738221085158 for Spectrum of Movement Disorders Among Children With Subacute Sclerosing Panencephalitis: A Cross-Sectional Study by Divyani Garg, Vanshika Kakkar, Ashna Kumar, Dipti Kapoor, Pooja Abbey, Harish Pemde, Sharmila B. Mukherjee and Suvasini Sharma in Journal of Child Neurology</p
sj-docx-2-jcn-10.1177_08830738221085158 - Supplemental material for Spectrum of Movement Disorders Among Children With Subacute Sclerosing Panencephalitis: A Cross-Sectional Study
No full textSupplemental material, sj-docx-2-jcn-10.1177_08830738221085158 for Spectrum of Movement Disorders Among Children With Subacute Sclerosing Panencephalitis: A Cross-Sectional Study by Divyani Garg, Vanshika Kakkar, Ashna Kumar, Dipti Kapoor, Pooja Abbey, Harish Pemde, Sharmila B. Mukherjee and Suvasini Sharma in Journal of Child Neurology</p
Comparison of Long-Term Outcomes in Patients with Supratentorial Spontaneous Intracerebral Hemorrhage Treated with and without Surgical Intervention
No full textOriginal Article
Comparison of Long-Term Outcomes in Patients with Supratentorial Spontaneous Intracerebral Hemorrhage Treated with and without Surgical Intervention
Sharma, Agrata*; Agarwal, Ayush*; Garg, Ajay1; Vishnu, Venugopalan Y; Nilima, N2; Bhatia, Rohit; Garg, Divyani; Pandit, Awadh K; Joseph, Leve1; Billa, Srujana; Singh, Manmohan3; Suri, Ashish3; Kale, Shashank S3; Gaikwad, Shailesh B1; Srivastava, MV Padma
Author Information
Annals of Indian Academy of Neurology 28(2):p 220-226, Mar–Apr 2025. | DOI: 10.4103/aian.aian_497_24
Open
Abstract
Background and Objectives:
Intracerebral hemorrhage (ICH) is associated with high mortality and morbidity. Uncertainty still exists regarding the benefit of surgery in the management of supratentorial spontaneous ICH (sICH), especially of the basal ganglia and thalamus. Studies have not shown the clinical benefit of early surgical management compared to best medical management plus delayed surgery, when necessary. Our aim was to compare the efficacy of different neurosurgical interventions with best medical management and best medical management alone.
Methods:
We conducted a single-center, retrospective study at a tertiary care center in India in sICH patients between January 2015 and December 2022. The primary outcome was functional disability evaluated by the modified Rankin Scale (mRS) at 3, 6, and 12 months. Time-to-event outcomes were compared using the Kaplan–Meier curve.
Results:
Among 2600 stroke patients screened, 661 had sICH. Median age was 55 years, and 250 patients (37.8%) underwent neurosurgical intervention. The most common intervention was craniotomy and hematoma evacuation. The median mRS at discharge and follow-up at 3, 6, and 12 months was lower in the conservatively managed group (4, 3, 3, and 3, respectively) compared to the surgical intervention group (5, 5, 5, 4, respectively). However, the ICH score at admission was lower in the conservatively managed group and after adjustment for ICH score, there was no statistically significant difference between the two. Among the interventions, patients undergoing decompression craniectomy had the best functional outcome.
Conclusions:
Neurosurgical intervention was not associated with better functional outcome when compared to conservative management
Major advances in amyotrophic lateral sclerosis in 2020
No full textResearch in amyotrophic lateral sclerosis (ALS), a neurodegenerative condition, has seen advancement in several key areas of research in 2020. These include a thrust to move the classification of ALS from a neuromuscular condition to a neurodegenerative condition, due to research suggesting involvement of cortical areas, and early cortical hyperexcitability. A new criterion for ALS, called the Gold Coast criterion, has been described. The Gold Coast criteria have removed the categories of possible, probable, and definite ALS, to make the diagnosis of ALS more inclusive and permit enhanced eligibility of patients in clinical trials for ALS. New biomarkers, both imaging and protein based, have been described. Advances in therapy have also occurred, with a large phase II clinical trial reporting benefits with sodium phenylbutyrate-taurursodiol
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