3,639 research outputs found
Host immune response boosting against murine colon carcinoma C26 Through OX40L co-stimulation
No full textHost immune response boosting against murine colon carcinoma C26 through OX40L co-stimulation
No full textReactions of a phosphinito bridged diplatinum(I) complex with coinage metal electrophiles
No full textWe have recently described the synthesis of the complex
[(PHCy2)Pt1(m-PCy2){k2P,O-m-P(O)Cy2}Pt2(PHCy2)] (Pt-Pt)
(1), the first unsymmetrical phosphinito bridged Pt(I) species.[1]
The phosphinito bridge differentiates the charge distributions on
the two platinum atoms as confirmed by NMR spectroscopy
(dPt(1) = -4798 ppm, dPt(2) = -5207 ppm) and DFT studies. Complex
1 shows a rich chemistry as it reacts with nucleophiles [PHCy2,
PCy3, P(S)HCy2],[2] protic species HX [P(OH)Cy2, PhSH, HF,
HCl, HBr, HI, HBF4],[3, 4] and small molecules such as H2.[5]
Recently, we started investigations on the reactivity of complex 1
towards Au and Ag based electrophiles.
In this communication, it will be shown that, differently
from the isolobal H+ (which attacks the phosphinito oxygen and
migrates onto the Pt-Pt bond),3 the [Ag(PPh3)]+ electrophile
attacks complex 1 selectively to the Pt2-mP bond to afford the
cationic cluster [(PHCy2)Pt1(m-PCy2){k2P,O-m-P(O)Cy2}Pt2{m-
-Ag(PPh3)}(PHCy2)]+ (Pt–Pt) (2+) in which the [Ag(PPh3)]+
moiety bridges the mP-Pt2 bond. Analogous reactivity is observed
also when phosphane free electrophiles such as AgOTf, AgBF4,
AgClO4 and AgCl are used. Moreover, the reactivity of 1 towards
Au(I) electrophiles such as AuCl and [Au(PPh3)Cl] was dependent
on the reagent and on the experimental conditions.
references:
1. Gallo, V.; Latronico, M.; Mastrorilli, P.; Nobile, C. F.;
Suranna, G. P.; Ciccarella, G.; Englert, U.; Eur. J. Inorg.
Chem., 2005, 4607–4616.
2. Gallo, V.; Latronico, M.; Mastrorilli, P.; Nobile, C. F.;
Polini, F.; Re, N.; Englert, U.; Inorg. Chem., 2008, 47,
4785–4795.
3. Latronico, M.; Polini, F.; Gallo, V.; Mastrorilli, P;
Calmuschi-Cula B.; Englert, U.; Re, N.; Repo T.,
Raisanen M.; Inorg. Chem., 2008, 47, 9979-9796.
4. M. Latronico, P. Mastrorilli, V. Gallo, M.M.Dell’Anna,
F. Creati, N. Re, U. Englert, Inorg. Chem. 2011, 50,
3539–3558
5. Mastrorilli P., Latronico M., Gallo V., Polini F., Re N.,
Marrone A., Gobetto R., Ellena S.. J. Am. Chem. Soc.
2010, 132, 4752–476
A double blind, placebo controlled, phase II, add-on study of cyclophosphamide (CTX) for 24 months in patients affected by Multiple Sclerosis on a backgroung therapy with Interferon-beta. Study denomination: CYCLIN
No full textCoherent Modeling and Forecasting of Mortality Patterns for Subpopulations Using Multiway Analysis of Compositions: An Application to Canadian Provinces and Territories
No full textMortality levels for subpopulations, such as countries in a region or provinces within a country, generally change in a similar fashion over time, as a result of common historical experiences in terms of health, culture, and economics. Forecasting mortality for such populations should consider the correlation between their mortality levels. In this perspective, we suggest using multilinear component techniques to identify a common time trend and then use it to forecast coherently the mortality of subpopulations. Moreover, this multiway approach is performed on life table deaths by referring to Compositional Data Analysis (CoDa) methodology. Compositional data are strictly positive values summing to a constant and represent part of a whole. Life table deaths are compositional by definition because they provide the age composition of deaths per year and sum to the life table radix. In bilinear models the use of life table deaths treated as compositions generally leads to less biased forecasts than other commonly used models by not assuming a constant rate of mortality improvement. As a consequence, an extension of this approach to multiway data is here presented. Specifically, a CoDa adaptation of the Tucker3 model is implemented for life table deaths arranged in three-dimensional arrays indexed by time, age, and population. The proposed procedure is used to forecast the mortality of Canadian provinces in a comparative study. The results show that the proposed model leads to coherent forecasts
Application of the IS-MP-IA model to the German economy and policy implications
No full textExtending the IS-MP-IA model developed by Romer (2000) and applying the GARCH (Engle, 1982, 2001) methodology, the author finds that equilibrium GDP in Germany is positively affected by stock market performance and real exchange rate appreciation, and negatively influenced by the expected inflation rate, the government deficit/GDP ratio, and the U.S. federal funds rate. The relatively low deficit/GDP ratio of 1.83% in 2003 indicates that its fiscal condition was healthy. However, some other EU members may need to exercise fiscal discipline. Because real appreciation has a positive impact on output, a stronger euro may not be a concern for Germany but may be worried by those EU member nations which depend upon exports to stimulate their economies.
IL-12 antitumor activity is independent of the direct effect of IFN-gamma on tumor cells
No full text
Winning redefined, a new brand positioning for MP Motorsport
No full textMP Motorsport is a talent educating race team participating in the classes below the Formula 1. The problem with the lower classes and therefore MP Motorsport as well is that these classes don’t get much attention and exposure. As a company run by people with passion the branding and positioning is more something that naturally emerged from this passion rather than a series of conscious decisions. This makes it fragile. A more conscious strategy and vision on how MP Motorsport needs to be branded and positioned against their competition that is more than “look how cool racing is” is needed to become more attractive for sponsoring. This report describes the process from analysis to finding the right positioning and an advise for a new brand identity and an implementation plan to help becoming more attractive for sponsoring goals. The analysis done with employees showed a unique characteristic that will help the team to position themselves against the competition; the family atmosphere. This atmosphere is what also characterises their contradictory personality. This personality is on one hand leading and ambitious and on the other hand modest and involved. Competition and stakeholder analysis have been performed to find the right combination of being unique to the competition, desirable for the stakeholders (the fans and sponsors) and builds upon the core strengths of the company. Then using the brand key model, a positioning is made with the essence: Be your best self. The belief, “in everyone hides a talent” and values like “everyone is equal” and “together we succeed” combined with the essence and the positioning resulted in a brand story that describes the feeling MP Motorsport wants to communicate. To manifestate the brand, an advise has been set up for a tone of voice and tone of image. Wrapped in a concept called “winning redefined” this advise is part of the whole implementation plan that should lead the way for the team to implement the newly created brand in short and long term actions. In 3 phases MP Motorsport is advised to start with a clear brand introduction to the target groups Gen Z and potential sponsors. The next phase revolves around creating a community to attract both Gen Z talents and subsequently sponsors to interact with the team and each other. Finally the last phase is long term focused and aims for sustainable growth. In this phase the community is established and can expect various opportunities to discover and develop a whole range of talents, sponsors and gen z are connected to each other via MP Motorsport and the team is able to finance the lower classes without the pressure of the money drivers bring along.Strategic Product Desig
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