1,720,984 research outputs found
Mechanical mixing device for cell culture multiwells
No full textDispositivo per la miscelazione meccanica di colture
cellulari in sospensione contenute in una piastra di
coltura, comprendente: - un coperchio 10 destinato ad
essere amovibilmente associato ad una piastra di
coltura P per schermare il pozzetto o i pozzetti W di
quest’ultima limitando l’ingresso di solidi sospesi
nell’aria ambiente, e al contempo permettendo
l’ingresso di gas e umidità esterni; - almeno una
girante di miscelazione 20 per ciascun pozzetto W della
piastra di coltura P; - mezzi motori 30 collegabili
cinematicamente a ciascuna girante 20.
La girante 20 è rotazionalmente associata al coperchio
10 in corrispondenza della faccia di quest’ultimo
destinata ad essere rivolta verso detta piastra di
coltura P. Almeno il coperchio 10 e le giranti 20 sono
realizzate con materiali che possono essere sottoposti
a trattamenti di sterilizzazione e sono in grado di
resistere alle condizioni di umidità, temperatura e pH
che si creano in un incubatore biologic
Clinical efficacy of gamma-hydroxybutyric acid in treatment of opiate withdrawal
No full textThis paper describes the role of gamma-hydroxybutyric acid (GHB) in the treatment of opiate withdrawal syndrome. In the two patients described, after having abruptly withdrawn from long-term methadone treatment, GHB was orally administered (each dose given every 46 h) for 8-9 days. The GHB showed both a high efficacy (some mild and transient symptoms attributable to opiate withdrawal were observed, but only in the first days of therapy) and a good tolerability (no clinical phenomena interpreted as GHB side effects were found). These results could be of interest in improving the pharmacological treatment of drug addiction
Strumenti di identificazione di patologie e problemi alcol correlati nell'utenza di un medico di base
No full text105 pazienti, presenti consecutivamente presso un ambulatorio di medicina di base, sono stati sottoposti a procedure diagnostiche opportunamente scelte allo scopo di appurare la % di bevitori inadeguati; di questi ne sono stati identificati 74 (70.5%) di cui 32 negano tale condizione
Gamma-hydroxybutyric acid in the treatment of alcohol dependence: A double-blind study
No full textThe effect of gamma-hydroxybutyric acid on alcohol consumption and alcohol craving in alcoholics was investigated in a randomized double-blind study versus placebo. Patients were treated as outpatients during a three month period either with gamma-hydroxybutyric acid (50 mg/kg/day, divided into three daily doses) or with placebo. Of the 82 alcoholics that entered the study, 71 completed it, 36 in the gamma-hydroxybutyric acid and 35 in the placebo group. Alcohol consumption was assessed by the subject's self report. At the 3rd month of treatment, 11 patients in the gamma-hydroxybutyric acid group referred to be abstinent and 15 referred controlled drinking; while in the placebo group only two and six patients referred abstinence and controlled drinking, respectively. Serum-gammaglutamyl-transferase activity correlated with the admitted alcohol consumption. Gamma-hydroxybutyric acid treatment decreased alcohol craving during the 3 months of treatment. Transient side effects were noted by six patients on gamma-hydroxybutyric acid and two on placebo. The results suggest that gamma-hydroxybutyric acid may be useful in the treatment of alcohol dependence
Gamma-hydroxybutyric acid for treatment of opiate withdrawal syndrome
No full textIn a double-blind placebo-controlled trial, gamma-hydroxybutyric acid (GHB) (25 mg/kg orally) suppressed most of the withdrawal symptomatology in 14 heroin addicts and 13 methadone-maintained subjects. The GHB effect was prompt (within 15 minutes) and persisted for between 2 and 3 hours. Subsequently, the same patients received GHB in an open study every 2 to 4 hours for the first 2 days and 4 to 6 hours for the following 6 days: most abstinence signs and symptoms remained suppressed and patients reported feeling well. Urine analysis failed to detect any presence of opiate metabolites. No withdrawal symptomatology recurred after 8 days of treatment when GHB was suspended, and patients were challenged with an intravenous injection of 0.4 mg naloxone. The results indicate that GHB may be useful in the management of opiate withdrawal
Gamma-hydroxybutyric acid for treatment of alcohol withdrawal syndrome
No full textThe effect of gamma-hydroxybutyric acid (GHB) on ethanol withdrawal syndrome in alcoholics was investigated in a randomised double-blind study. Patients with withdrawal symptoms were treated either with GHB (orally in a syrup preparation) (11 patients) or with the syrup alone (12). GHB treatment (50 mg/kg) led to a prompt reduction in withdrawal symptoms, such as tremors, sweating, nausea, depression, anxiety, and restlessness. The only side-effect was dizziness. GHB may be useful in the management of alcohol withdrawal syndrome in man
Il trapianto in soggetti con problemi di abuso/dipendenza. Modalità di valutazione preventiva
No full text- …
