2,052 research outputs found
Some differences in the rates of convergence of the sample covariance and covariation functions
No full textPUL897513 Supplemental material - Supplemental material for Understanding longitudinal biventricular structural and functional changes in a pulmonary hypertension Sugen–hypoxia rat model by cardiac magnetic resonance imaging
No full textSupplemental material, PUL897513 Supplemental material for Understanding longitudinal biventricular structural and functional changes in a pulmonary hypertension Sugen–hypoxia rat model by cardiac magnetic resonance imaging by Geeshath Jayasekera, Kathryn S. Wilson, Hanna Buist, Rosemary Woodward, Aysel Uckan, Colin Hughes, Margaret Nilsen, A Colin Church, Martin K. Johnson, Lindsay Gallagher, James Mullin, Mandy R. MacLean, William M. Holmes, Andrew J. Peacock and David J. Welsh in Pulmonary Circulation</p
Ribozyme catalysis with a twist: active state of the twister ribozyme in solution predicted from molecular simulation
No full textWe present results from molecular dynamics simulations and free energy calculations of the twister ribozyme at different stages along the reaction path to gain insight into its mechanism. The results, together with recent biochemical experiments, provide support for a mechanism involving general-acid catalysis by a conserved adenine residue in the active site. Although adenine has been previously implicated as a general acid acting through the N1 position in other ribozymes such as the hairpin and VS ribozymes, in the twister ribozyme there may be a twist. Biochemical experiments suggest that general acid catalysis may occur through the N3 position, which has never before been implicated in this role; however, currently, there is a lack of a detailed structural model for the active state of the twister ribozyme in solution that is consistent with these and other experiments. Simulations in a crystalline environment reported here are consistent with X-ray crystallographic data, and suggest that crystal packing contacts trap the RNA in an inactive conformation with U-1 in an extruded state that is incompatible with an in-line attack to the scissile phosphate. Simulations in solution, on the other hand, reveal this region to be dynamic and able to adopt a conformation where U-1 is stacked with G33. In this state, the nucleophile is in line with the scissile phosphate, and the N1 position of G33 and N3 position of A1 are poised to act as a general base and acid, respectively, as supported by mutational experiments. Free energy calculations further predict the electrostatic environment causes a shift of the microscopic pKa at the N3 position of A1 toward neutrality by approximately 5 pKa units. These results offer a unified interpretation of a broad range of currently available experimental data that points to a novel mode of general acid catalysis through the N3 position of an adenine nucleobase, thus expanding the repertoire of known mechanistic strategies employed by small nucleolytic ribozymes.Peer reviewe
Public Policy in a Private Arena: The Case of Vocational Education and Training
Full text linkM.21586-1998 Colin Crouch. 30 cm. This paper is based on a seminar that he presented at the Center for Advanced Study in the Social Sciences of the Juan March Institute, Madrid, on 9 May 1995, entitled Diversity in Modern Capitalism: Examples from Vocational Education." -- T.p. Includes bibliographical references (p. 35-37
Orbit design for future SpaceChip swarm missions in a planetary atmosphere
No full textThe effect of solar radiation pressure and atmospheric drag on the orbital dynamics of satellites-on-a-chip (SpaceChips) is exploited to design equatorial long-lived orbits about the oblate Earth. The orbit energy gain due to asymmetric solar radiation pressure, considering the Earth's shadow, is used to balance the energy loss due to atmospheric drag. Future missions for a swarm of SpaceChips are proposed, where a number of small devices are released from a conventional spacecraft to perform spatially distributed measurements of the conditions in the ionosphere and exosphere. It is shown that the orbit lifetime can be extended and indeed selected through solar radiation pressure and the end-of-life re-entry of the swarm can be ensured, by exploiting atmospheric drag
Vascular healing : cell biology and rheologic factors
No full textIssued as Progress report summary, Project E-25-M44 (continued by E-25-M80)Progress report summary has author: Colin J. Schwart
Vascular healing : cell biology and rheologic factors
No full textIssued as Progress report summary, Project no. E-25-M80 (continued by E-25-M44; continues E-25-614)Progress report summary has author: Colin J. Schwart
Are schools panoptic?
Full text linkSchools are often understood by social researchers as panoptic spaces, where power is exercised through constant surveillance and monitoring. In this paper, I use Foucault’s notorious account of the Panopticon as a point of departure for a detailed empirical investigation of the specificities of surveillance in schools. Drawing on ethnographic data from fieldwork in a primary school, I argue that how surveillance actually operated in this context diverged from the panoptic programme in two crucial ways: surveillance was (i) discontinuous rather than total, and therefore open to resistance and evasion, and (ii) exercised through sound and hearing as much as through vision
Oregon statewide status and trends report
No full textReport -- Appendix A. Black Rock Desert-Humboldt -- Appendix B. Columbia River -- Appendix C. Deschutes -- Appendix D. Goose Lake -- Appendix E. Grande Ronde -- Appendix F. John Day -- Appendix G. Klamath -- Appendix H. Malheur -- Appendix I. Mid Coast -- Appendix J. Middle-Columbia-Hood -- Appendix K. North Coast-Lower Columbia -- Appendix L. Oregon Closed Basins -- Appendix M. Owyhee -- Appendix N. Powder-Burnt -- Appendix O. Rogue -- Appendix P. Sandy -- Appendix Q. Snake River -- Appendix R. South Coast -- Appendix S. Umatilla-Walla Walla-Willow -- Appendix T. Umpqua -- Appendix U. Willamette.prepared by: Colin Donald and Ryan Michie.Title from PDF cover (viewed on November 4, 2022).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
La structure cristalline du tétracyanoplatinate de potassium et sodium trihydraté
No full textKNaPt (CN)₄. 3H₂O is monoclinic with Z = 4.
a = 11.74 Å ; b = 13.74 Å ; c = 6.50 Å ; β = 94° 47'.
The determination of the structure is based on the analysis of the (001) and (010) projections. The R value is 7.9 % for the planes (hk0) and 9,3 % for the planes (h0l).
The author gives also a discussion of the structure.KNaPt (CN)₄. 3H₂O est monoclinique avec 4 unités formulaires par maille ;
a = 11,77 Å ; b = 13,74 Å ; c = 6,50 Å ; β = 94° 47'.
La détermination de la structure est basée sur l'analyse des projections (001) et (010). Le facteur R est 7,9 % pour l'ensemble des plans (hk0) et 9,3 % pour l'ensemble des plans (h0l).
L'auteur donne aussi une discussion de la structure.Moreau-Colin M.-L. La structure cristalline du tétracyanoplatinate de potassium et sodium trihydraté. In: Bulletin de la Société française de Minéralogie et de Cristallographie, volume 91, 4, 1968. pp. 332-338
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