35 research outputs found
Incorrect Spelling of Author Name
No full textIn the Article titled “Robotic resection of mediastinal left vagus neurofibroma” published on June 12, 2022, in the Early Access issue of Monaldi Archives for Chest Disease, an author name was misspelled. In the byline, the fifth author, “Sergio Nicola Fortiparri” should have been “Sergio Nicola Forti Parri.” This article was corrected online.
Reference
Brandolini J, Ambrosi F, Bertoglio P, et al. Robotic resection of mediastinal left vagus neurofibroma. Monaldi Arch Chest Dis 2023;93:2248. https://doi.org/10.4081/monaldi.2022.2248
Survey techniques integrating smartphone lidar and UAV photogrammetry: the example of the anthropic underground cavities of Montefiascone (Viterbo, Central Italy)
No full textMany of Latium’s small towns developed on volcanic units, such as
Montefiascone, have a subsoil rich in underground cavities made by humans over millennia for multiple purposes that present a wide range of shapes and sizes. They vary from narrow tunnels, presumably connected to hydraulic works of Etruscan and Roman times, to other works made in medieval and modern times. In the contemporary ages, these cavities have often been connected, enlarged and adapted as cellars, storage rooms, etc. To reduce the risk of sinkhole opening on the surface it is crucial to have a complete knowledge of these underground cavity systems. The problem is carrying out, quickly and cost-effectively, a first census of these cavities or at least those accessible, either without restriction or with the aid of speleological techniques. Lidar
Technology uses laser technology to make a 3D survey of these environments. It has been available for years on professional instruments such as Laser scanners. However, these instruments present encumbrance problems and poor transportability in underground environments, partly outdated with new generation devices (e.g., SLAM laser scanner), but their costs remain high for non-professional uses. Recently, this technology has also been implemented on some models of tablets and smartphones at a relatively low cost. This study aims to demonstrate the limits and the possibilities of using these relatively new and inexpensive tools integrated with traditional topographical surveying techniques (compass and tape) in creating 3D models of some ontefiascone
underground cavities
Vernacular Metaphysics in Renaissance Ragusa
No full textThis paper focuses on two almost forgotten works. Both were posthumously published together in 1599 and their titles are Irene, Overo della Bellezza and Compendio breve della metafisica. The author of these works was Michele Gabriele, better known as Michele or Miho Monaldi. These writings are the expression of the two main aforementioned metaphysical tendencies of the time: one of Platonic inspiration and the other of Aristotelian doctrine. They are not works of marked originality, but precisely for this reason they are representative of their specific field
The Renaissance Art of Dialog: Miho Monaldi, The Treatise on Beauty
Get PDFU članku se analiziraju filozofsko-estetičke ideje, stajališta i nazori dubrovačkog renesansnog filozofa, pjesnika i pisca Mihe Monaldija (1540–1592) u kontekstu struja i tendencija u filozofiji i književnosti 16. stoljeća.
Uz filozofsko-estetičku dimenziju, razmatraju se i stilsko-formalne i idejno-motivičke odrednice njegove estetičke rasprave (dijaloga) »Irene overo della bellezza« u obzoru europske i domaće dijaloške tradicije.
Utvrđuje se mjesto, značenje i narav Monaldijevog dijaloškog modela, podudarnosti i razlike njegova modela i nekih filozofskih pisaca tog doba (Petrić, Gučetić, Castelvetro, i dr.).The paper analyses the philosophical-esthetic ideas and views of the Renaissance philosopher, poet, and author Miho Monaldi from Dubrovnik (1540–1592) in the context of the trends and tendencies in the sixteenth-century philosophy and literature.
The authoress analyses the philosophical-esthetic dimensions and the ideational-motivational characteristics of Monaldi’s esthetic treatise (dialog) »Irene overo della bellezza« in the context of European and domestic dialog tradition.
The position, significance, and nature of Monaldi’s model of the dialog are defined, as well as the similarities and differences of the model in relation to several other philosophical authors of the period (Petrić, Gučetić, Castelvetro, and others)
Ponatinib treatment in chronic myeloid leukemia cell lines targets aurora kinase A/FOXM1 axis
No full textNo abstract availabl
The Impact of the Decline in Oil Prices on the Economics, Politics and Oil Industry of Venezuela
No full textIn this paper, the author weighs the difficulties facing Venezuela in light of its dependence on oil export revenues
FOXM1 Transcription Factor: A New Component of Chronic Myeloid Leukemia Stem Cell Proliferation Advantage
No full textFOXM1 transcription factor is a central component of tumor initiation, growth, and progression due to its multiple effects on cell cycle, DNA repair, angiogenesis and invasion, chromatin, protein anabolism, and cell adhesion. Moreover, FOXM1 interacts with β-catenin promoting its nuclear import and transcriptional activation. Here, we show that FOXM1 is involved in the advantage of chronic myeloid leukemia hematopoiesis over the normal counterpart. FOXM1 hyper-activation associated with BCR-ABL1 results from phosphorylation by the fusion protein kinase-dependent activation of Polo-like kinase 1. FOXM1 phosphorylation lets its binding with β-catenin and β-catenin transcriptional activation, a key event for persistence of the leukemic stem cell compartment under tyrosine kinase inhibitor therapy. Polo-like kinase 1 inhibitor BI6727, already advanced for clinical use, breaks β-catenin interaction with FOXM1, hence hampering FOXM1 phosphorylation, β-catenin binding, nuclear import, and downstream signaling. In conclusion, our results support Polo-like kinase 1/FOXM1 axis as a complementary target to eradicate leukemic early progenitor/stem cell compartment in chronic myeloid leukemia
An atypical acute exacerbation of COPD due to Aspergillus fumigatus
No full textPubMed: 31986874A 64-year-old male with a history of stabile chronic obstructive pulmonary disease (COPD) presented with increasing dyspnea and sputum for the last two months. Complete blood count showed WBC 14x103/ml, Hgb: 14.2 g/dL and eosinophilia. Blood biochemistry was normal. Chest x-ray showed hyperlucency while thorax computed tomography (CT) revealed obstructive lung disease and bronchiectasis. Pulmonary function tests demonstrated severe obstructive lung disease and a negative bronchoreversibility with a moderately reduced diffusing capacity/alveolar volume (DLCO/VA). ABG gases revealed significant hypoxemia. Sputum culture was negative. Total IgE was 1140 ng/ml. Aspergillus RAST, precipitins and aspergillus-galactomannan antigen were positive. CF genetic screening tests gave negative results. Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity reaction that occurs due to bronchial aspergillus colonization. It is most common in patients with asthma and cystic fibrosis. We present a COPD case with an acute exacerbation due to Aspergillus fumigatus that lead to an aberrant clinical profile unresponsive to conventional treatment. Clinicians should consider Aspergillus fumigatus as an etiologic agent in an atypical and severe COPD exacerbation. © Copyright the Author(s), 2020 Licensee PAGEPress, Ital
Diabetes is a Strong Predictor of Mortality During Tuberculosis Treatment: A Prospective Cohort Study Among Tuberculosis Patients from Mwanza, Tanzania.
Get PDFStrong evidence suggests diabetes may be associated with tuberculosis (TB) and could influence TB treatment outcomes. We assessed the role of diabetes on sputum culture conversion and mortality among patients undergoing TB treatment. A total of 1250 Tanzanian TB patients were followed prospectively during TB treatment with sputum culture after 2 and 5 months. Survival status was assessed at least 1 year after initiation of treatment. At baseline, all participants underwent testing for diabetes and HIV, and the serum concentration of the acute phase reactant alpha-1 glycoprotein (AGP) was determined. There were no differences between participants with and without diabetes regarding the proportion of positive cultures at 2 (3.8% vs. 5.8%) and 5 (1.3% vs. 0.9%) months (P > 0.46). However, among patients with a positive TB culture, relatively more patients with diabetes died before the 5-month follow-up. Within the initial 100 days of TB treatment, diabetes was associated with a fivefold increased risk of mortality (RR 5.09, 95% CI 2.36; 11.02, P < 0.001) among HIV uninfected, and a twofold increase among HIV co-infected patient (RR 2.33 95% CI 1.20; 4.53, P = 0.012), while diabetes was not associated with long-term mortality. Further adjustment with AGP did not change the estimates. Diabetes considerably increases risk of early mortality during TB treatment. The effect may not be explained by increased severity of TB, but could be due to impaired TB treatment response. Research is needed to clarify the mechanism and to assess whether glycaemic control improves survival
Bone Marrow Stem Cell Treatment for Ischemic Heart Disease in Patients with No Option of Revascularization: A Systematic Review and Meta-Analysis
No full textPMCID: PMC3686792This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
