196,171 research outputs found
Dataset - Experimental Data of a Hexagonal Floating Structure under Waves
No full textFloating structures have a wide range of application and shapes. This experimental investigations observes a hexagonal floating structure under wave conditions for three different draft configurations. Regular waves as well as a range of white noise tests were conducted to quantify the response amplitude operator (RAO). Further irregular waves focused on the survivability of the floating structure. The presented dataset includes wave gauge data as well as 6 degree of freedom motion measurement to quantify the response only restricted by a soft mooring system. Additional analysis include the measurement of the mass properties of the individual configuration, natural frequency of the mooring system as well as the comparison between requested and measured wave heights. This allow to use the provided dataset as a validation experiment. This research was carried out at the FloWave Ocean Energy Research Facility of the Institute for Energy Systems, University of Edinburgh
CAD files for the Swing to measure the Centre of Gravity and Moment of Inertia
No full textThe dataset provides the CAD files describing the swing, which is available in FloWave Ocean Energy Research Facility. The described experimental setup can be used to measure the centre of gravity and the moment of inertia with one degree of freedom. The swing is supported by two movable frames. Two different pivot axes are available and the measurement process as well as the analysis is presented in a separate paper. The provided files allow to check how a potential model can be placed on the swing and supports the usage of this device. Four different types of files are available: IGES (igs), ACIS (sat), STL Stereolithography (stl) and Rhinoceros (3dm). The geometry was constructed in mm
Additional Experimental Data of a Floating Cylinder in a Wave Tank - Verification Experiments
No full textThe presented experimental results provide additional data to a previously published investigation of a floating cylinder under regular wave conditions (https://doi.org/10.7488/ds/2627). Three test series are added to investigate the roll response of the water filled structure. This includes a change of the initial position of the cylinder in the wave tank as well as a rotation of the wave direction. The latter was also conducted for the solid ballast option to provide a direct comparison with the water filled cylinder.
This research was carried out at the FloWave Ocean Energy Research Facility of the Institute for Energy Systems, University of Edinburgh
Vascularized Small-Bone Transfers for Fracture Nonunion and Bony Defects
No full textVascularized small-bone grafting is an efficient and often necessary surgical approach for nonunion or necrosis of several bones in particular sites of the body, including scaphoid, lunate, distal ulna, and clavicle. The medial femoral condyle is an excellent graft source that can be used in treating scaphoid, ulna, clavicle, or lower-extremity bone defects, including nonunion. Vascularized bone grafting to the small bones, particularly involving reconstruction of damaged cartilage surfaces, should enhance subchondral vascular supply and help prevent cartilage regeneration. Vascularized osteoperiosteal and corticoperiosteal flaps are useful for treating nonunion of long bones
Dataset - Bottom Pressure and Free Surface Elevation Including Waves and Current Interaction
No full textForce plates are commonly used in tank testing to measure loads acting on the foundation of a structure. These targeted measurements are overlaid by the hydrostatic and dynamic pressure acting on the force plate induced by the waves and currents. This paper presents the dataset of bottom force measurement with a six degree-of-freedom force plate (AMTI OR6-7 1000, surface area 0.464 m×0.508 m) combined with synchronised measurements of surface elevation and current velocity. The data covers a wave frequencies between 0.2 to 0.7 Hz and wave direction between 0◦ and 180◦. These variations are provided for 0 and 0.2 m/s current speed and a variation of current in the absence of waves covering 0 to 0.45 m/s. The dataset can be utilised as a validation dataset for models predicting bottom pressure based on free surface elevation. Additionally, the dataset provides the wave and current induced load acting on the specific load cell and a fixed water depth of 2 m, which can subsequently be removed to obtain the often-desired measurement of structural loads. This research was carried out at the FloWave Ocean Energy Research Facility of the Institute for Energy Systems, University of Edinburgh
Vascularized Small-Bone Transfers for Fracture Nonunion and Bony Defects
No full textVascularized small-bone grafting is an efficient and often necessary surgical approach for nonunion or necrosis of several bones in particular sites of the body, including scaphoid, lunate, distal ulna, and clavicle. The medial femoral condyle is an excellent graft source that can be used in treating scaphoid, ulna, clavicle, or lower-extremity bone defects, including nonunion. Vascularized bone grafting to the small bones, particularly involving reconstruction of damaged cartilage surfaces, should enhance subchondral vascular supply and help prevent cartilage regeneration. Vascularized osteoperiosteal and corticoperiosteal flaps are useful for treating nonunion of long bones
Experimental Data of a Floating Cylinder in a Wave Tank – Comparison Solid and Water Ballast
No full textThe experimental set-up allows for the comparison of two different ballast options of a floating cylinder in a wave tank. Four different internal water drafts are tested as well as an equivalent solid ballast option. The model is excited by regular waves which are characterised with five wave gauges in front of the floating cylinder and two behind. Additionally, the time series of the six-degree of freedom response of the floating structure is made available. Regular waves with an initial amplitude of 0.05 m and frequencies over the range 0.3 to 1.1 Hz are investigated. This results in a wide range of different responses of the floating structure as well as very big rotations of up to 20 degrees. This data-set allows for identification of the influence caused by the sloshing of the interior water volume and can be used to validate numerical models of fluid-structure-fluid interaction. This research was carried out at the FloWave Ocean Energy Research Facility of the Institute for Energy Systems, University of Edinburgh
Modulation of Receptor Signaling and Functional Selectivity in Neutrophils
No full textNeutrophils are important effector cells of the innate immune system and in the regulation of inflammation. Many of their functions, such as chemotactic migration, secretion of granule constituents and activation of the oxygen radical-producing NADPH-oxidase, are regulated by cell surface receptors. The formyl peptide receptors (FPRs), the ATP receptor (P2Y2R) and the receptor for platelet activating factor (PAFR) belong to the large family of G-protein coupled receptors (GPCRs) and, amongst other receptors, enable neutrophils to sense and respond to host- and pathogen-derived danger signals. Therefore, any regulatory imbalance in GPCR signaling can potentially contribute to the development of severe infections or autoimmune/inflammatory diseases.
The work presented in this thesis is focused on basic GPCR-signaling mechanisms in human neutrophils with the aim to generate new knowledge that could be of value for future GPCR-based drug development. To answer the scientific questions raised, numerous cell-biology-based experimental methods were applied, including measurements of neutrophil intracellular calcium release, superoxide production, degranulation, cell migration and cytoskeleton-mediated receptor regulation.
The functional responses triggered by GPCRs expressed by neutrophils can be modulated in various ways at the level of receptors/ligand interaction, in dependence of other GPCRs, as well as at the signaling level. Both FPR2 and P2Y2R have been shown to be able to exert functional selective signaling through distinct regulatory mechanisms. An FPR2-specific synthetic lipopeptide allosteric modulator was identified as a biased agonist that does not induce recruitment of β-arrestin or chemotactic migration and exhibits oppositional efficacies for direct FPR2 activation and receptor cross-talk-mediated signaling. Functional selectivity liked to the P2Y2R is not related to biased agonism but instead emerges from an endogenous actin cytoskeleton-dependent regulatory mechanism which selectively inhibits the signals that lead to the generation of oxygen radicals, while leaving other signaling pathways unaffected.
In conclusion, this thesis adds new knowledge to the field of neutrophil receptor biology and provides novel insights into the modulation of basic GPCR signaling mechanisms with intend to contribute to strategies for future drug design and treatment of inflammatory disorders and disease
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
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