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Linkage of biopsy, cancer, and population records aimed at the estimation of family risks in neoplasia: a pilot study
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LINKAGE OF BIOPSY, CANCER, AND POPULATION RECORDS AIMED AT THE ESTIMATION OF FAMILY RISKS IN NEOPLASIA - A PILOT-STUDY
Author(s): BARRAI, I (BARRAI, I); NENCI, I (NENCI, I); GUIDI, E (GUIDI, E); DELLACQUA, G (DELLACQUA, G); FORMICA, G (FORMICA, G); BARBUJANI, G (BARBUJANI, G); MARZOLA, A (MARZOLA, A); MARANI, G (MARANI, G); BARALE, R (BARALE, R); BERETTA, M (BERETTA, M)
Source: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH Volume: 45 Issue: 2 Pages: 107-111 DOI: 10.1136/jech.45.2.107 Published: JUN 1991
Times Cited: 1 (from Web of Science)
Cited References: 15 [ view related records ] Citation Map
Abstract: Study objective-The aim was to link individual demographic and medical records into sibships to obtain the sibling distribution of biopsies and cancers, and thereby calculate heritability and recurrence risks in families, thus aiding early diagnosis and prevention of cancers.
Design-The 157 823 individual records of the inhabitants of the town of Ferrara in Italy were automatically linked into 106 821 sibships. A 10% sample (10 842 sibships) was then extracted from the distribution of sibships and tabulated, for linkage to medical records.
Patients-The biopsy records at the Institute of Pathological Anatomy of the University of Ferrara were manually linked to cancer records and then to sibships. It was possible to construct the distribution of 2062 biopsies and of 829 cancers in sibships.
Results-From the distribution of biopsies and tumours in sibships, it was possible to estimate the incidence of tumours in the population (0.052) and in siblings of affected (0.083), and to apply to such distributions current methods for the estimate of heritability (h2 = 0.246) and of recurrence risks of tumours in sibships, age independent.
Conclusions-The study shows that the procedure resulting in the estimation of incidences and recurrence risks for tumours could be completely automated, and extended to whole populations and homogeneous subgroups in post industrial cultures
Nanoremediation: valutazione della potenziale capacità di nanoparticelle di TiO2 di contrastare gli effetti genotossici di contaminanti ambientali. approccio in vitro su biopsie branchiali di Mytilus galloprovincialis
No full textNanoremediation: valutazione della potenziale capacità di nanoparticelle di TiO2 di contrastare gli effetti genotossici di contaminanti ambientali. approccio in vitro su biopsie branchiali di Mytilus galloprovincialis
M. Bernardeschi a, P. Guidi a, M. Palumbo a, V. Scarcelli a, G. Frenzilli a
a Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa. Via A. Volta, 4 56126 Pisa - [email protected]
Abstract -. Le nanoparticelle (particelle con almeno una dimensione < 100 nm), grazie alle loro peculiari caratteristiche chimico-fisiche, possono essere impiegate con successo nella bonifica di ambienti contaminati.
Si è andati a valutare in vitro, su biopsie branchiali di Mytilus galloprovincialis la potenziale capacità di nanoparticelle di biossido di titanio (anatasio 25 nm; Degussa 70% di anatasio, 21nm; anatasio mesoporoso 14 nm) di interagire con il cadmio (CdCl2), contaminante classico dell’ambiente marino, diminuendone l’effetto genotossico. Grazie al Comet assay, nella sua versione alcalina, è stata valutata da una parte la genotossicità del CdCl2, e dall’altra la capacità delle nanoparticelle di titanio di abbattere tale effetto. E’ stata inoltre indagata la frequenza di cellule apoptotiche, tramite l’utilizzo del Diffusion assay.
I risultati relativi al Comet assay, sebbene preliminari, hanno mostrato una generale riduzione del livello di danno al DNA indotto dal CdCl2 nelle co-esposizioni, sebbene solo nel caso dell’anatasio di 25 nm tale effetto sia risultato statisticamente significativo. Dall’analisi dei preparati di Diffusion assay non è emersa alcuna percentuale significativa di cellule apoptotiche, né in relazione al trattamento col solo CdCl2, né rispetto a quello in co-esposizione con il titanio. Questo dato va a supportare la fondatezza dei risultati ottenuti con il Comet assay, legati esclusivamente all’effetto dei trattamenti e non ad una elevata mortalità cellulare
Coastal retreat and marine flooding scenario for 2100: A case study along the coast of Maddalena peninsula (southeastern Sicily)
No full textANZIDEI M., SCICCHITANO G., TARASCIO S., DE GUIDI G., MONACO C., BARRECA G., MAZZA G., SERPELLONI E. & VECCHIO A., Coastal retreat and marine flooding scenario for 2100: a case study along the coast of Maddalena Peninsula (southeastern Sicily). (IT ISSN 0391-9838, 2018). The coastal area of southeastern Sicily (Italy) is undergoing weak land subsidence, heavy coastal retreat, land flooding and exposed to severe storms associated with high-waves, also in consequence of the global sea level rise, which is expected to raise even more that 1 m by 2100 AD depending on different estimates. This value will be even larger in subsiding coasts, entailing widespread environmental changes, coastal retreat, marine flooding and loss of land, which will be subtracted to human activities. To understand the impact of rising sea level on the coast of Maddalena Peninsula, near the town of Siracusa, we realized a very high resolution Digital Terrain Model (DTM) through aerial photogrammetric surveys, obtained by Unmanned Aerial Vehicles (UAV) on which we projected the expected coastline for 2100 AD. Here we show a detailed marine flooding scenario for 2100, as generated from: i) high resolution DTM, ii) rate of land subsidence from GPS data and iii) predicted sea level projections from the IPCC AR5 reports (RCP2.6 and RCP8.5). Our analysis estimates a maximum relative sea level rise at 0.20 m and 0.65 m for 2050 AD and 2100 AD, respectively for AR 8.5 scenario. The increased sea levels will cause relevant morphological changes to the investigated coast with a maximum beach retreat of 27 m and a loss of land of 7400 m2, affecting building integrity and people safety
Sensors and Microsystems. Proceedings of the 9th Italian Conference, Ferrara, Italy, 8 – 11 February 2004
No full textThis indispensable volume contains a selection of papers presented at the 9th Italian Conference on Sensors and Microsystems, organized by AISEM (Associazione Italiana Sensori e Microsistemi). Many essential aspects of the disciplines related to advanced sensors and microsystems are covered, ranging from nano- and new materials to applications, multifunctional systems, micromechanics, and new technology. 83 papers from 103 institutions are featured, an indication of the very active research currently progressing in Italy. The wide range of contributions reflects the multidisciplinary character of the community encompassing physics, chemistry, biology, engineering, medicine, and others
Giulio Schmiedt, Il livello antico del Mar Tirreno. Testimonianze dei resti archeologici, con la collaborazione di M. Caputo, G. Conta, F. Guidi, M. Pellegrini, L. Pieri
No full textVan Wonterghem Frank. Giulio Schmiedt, Il livello antico del Mar Tirreno. Testimonianze dei resti archeologici, con la collaborazione di M. Caputo, G. Conta, F. Guidi, M. Pellegrini, L. Pieri. In: L'antiquité classique, Tome 43, fasc. 1, 1974. pp. 660-662
Possible unslipped segments in the M. Vettore Fault System
No full textOn October 30, 2016, in Central Italy, immediately north of the epicentral area of the August 24 event a strong eartquake (Mw = 6.5) reactivated the northern sector of the Monte Vettore Fault System (MVFS). Our local geodetic network was fully affected by the new event and therefore we performed a second campaign soon after (November 11-13, 2016) (Fig. 1 and Tab. 1) (De Guidi et al., in press)
Design spectra to be used in Base Isolation Design in light of recent strong motion records
No full textStrong motion records have shown an increase of the maximum values of PGA and PGV, also associated to the increase of the archived strong motion records. Nowadays, the worldwide largest PGA values are: 3,94g (vertical) and 2,75g (horizontal), from the 2008 Iwate-Miyagi and 2011 Tohoku earthquakes, while the current PGV maxima are larger than 2.0 m/s (horizontal and vertical). These unforeseen values have encouraged a more conscious approach in BIS design, being necessary to move to larger design periods and to face wider design displacements. Many changes have occurred in the history of BIS, as indicated in Design Recommendations for Seismically Isolated Buildings by AIJ (2016), tracing the improvements of BIS in Japan, and in De Luca and Guidi (2019). In this excursion, a significant contribution has been given by Miyazaki (2008) that defined a "Next Generation of seismic isolation" to counteract the unprecedented spectral values of displacement and acceleration. In this perspective, the paper analyzes the acceleration, velocity and displacement spectra of different sets of strong motion records to provide suggestions for seismic design of base-isolated structures in the light of higher spectral values. In particular, we will consider: the set defined in Trevor Kelly (2001), that divided motions into pre-1971 and post-1971; the set of FEMA307 (1999), in which three categories of ground motion are considered (short duration, long duration and forward directivity); the set used by Miyazaki (2008) for the Next Generation of Seismic Isolation; the set defined by Suzuki and Iervolino (2017) to trace the history of largest PGA and PGV; the set used by De Luca and Guidi (2019) to trace the improvements in BIS design and propose a classification of BIS in three successive generations. A comparison between results, for different periods, will lead to possible design indications for BIS
Massive 3D Digitization of Museum Contents
No full textThe goal of the 3D-ICONS European Project is to provide EUROPEANA ( www.europeana.eu ) with accurate 3D models of architectural and archaeological monuments and buildings of remarkable cultural importance. The purpose of this paper is to describe the specific processing pipeline that has been set for digitizing a significant part of the Civic Archaeological Museum in Milan (Italy). All the technical and logistic aspects needed for capturing 3D models in a Museum environment, the implication with IPR, and the metadata acquisition, are covered. The main issue is generating a good result by the technical point of view, minimizing the impact on the usual Museum activity during the 3D capturing operations, shortening in the meantime the processing time to the minimal allowed by the different applicable techniques. This condition has led different choices related to the survey technologies (laser scanning and image based modeling) and the related data processing. Both technical and descriptive metadata have been collected for each item acquired, for generating a record of data searchable on EUROPEANA, with the addition of new metadata not defined in the minimal record, for making traceable the path leading to the generated digital content. The paper gives a general discussion of such issues with some specific examples referred to the large set of 3D objects digitized within the 3D-ICONS project
A Semi-Classical Approach for Determination of the Inter-Granular Energy-Barrier Height in Very-Fine Nanograins
No full textThe height of the inter-grain energy barrier plays a key role in the determination of the conductive properties of semiconducting nanograins. In the limit of very-fine nanograins (≈ 1 nm), quantum effects start being relevant in the determination of physical properties. We approached the problem in a semi-classical method such as the Thomas-Fermi equation
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