1,721,016 research outputs found

    Pyrazolo[3,4-d] [1,2,3]triazole-1-carboxamides and 5-alkylamino pyrazolo[3,4-d]oxazoles: synthesis and evaluation of the in vitro antifungal activity

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    A series of N-alkyl-N'-(4-diazo-5-pyrazolyl)-ureas (4) was thermally and photochemically converted into pyrazolo [3,4-d][1,2,3]triazole derivatives (5,6) and 5-alkylaminopyrazolo[3,4-d]oxazoles (7) respectively. The products were tested for in vitro antifungal activity against Fusarium culmorum, Botrytis cinerea, Phoma betae, Pythium ultimum, Sclerotinia minor and Rhizoctonia solani. The MIC and ED50 values of compound (6) against some of the test fungi were comparable to those of the reference fungicides iprodione and mancozeb

    Imidazo[4,5-c]pyrazoles Synthesis of 4-,5- and 6-Substituted Derivatives

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    The syntheses of 4-, 5-, and 6-substituted imidazo[4,5-c]pyrazoles, compounds of potential biological activity, are reported. Copyright © 1996 Published by Elsevier Science Ltd

    Synthesis of 6,7-Disubstituted Pteridine –2,4-Diones

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    The reaction of pyrimido[5,4-c][1,2,5]oxadiazin-3(5H)-one (1) with carbon nucleophiles afforded pteridine-2,4-diones (3) bearing a variety of substituents unequivocally positioned in the pyrazine ring. © 1991

    Modificazioni molecolari di vitamine antiossidanti come mezzo per ottenere anti-aging

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    Modificazioni molecolari di vitamine antiossidanti come mezzo per ottenere anti-aging

    Synthesis of 4‐thiocarbamoyl‐5‐aminopyrazoles

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    Aryl and t‐butylhydrazines react with 2‐cyano‐3‐ethoxythiocrotonamide affording 2‐cyano‐3‐aryl‐t‐butylhy‐drazinothiocrotonamides. These intermediates can be easily cyclized to 4‐thiocarbamoyl‐5‐aminopyrazoles by heating a few minutes in a strong base. Alkylhydrazines react with 2‐cyano‐3‐ethoxythiocrotonamide yielding directly a mixture of the cyclized compounds 4‐cyano‐5‐aminopyrazoles and 4‐thiocarbamoyl‐5‐aminopyr‐azoles. Copyright © 1985 Journal of Heterocyclic Chemistr
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