1,721,051 research outputs found
Why does thermomagnetic resonance affect cancer growth? A non-equilibrium thermophysical approach
Full text linktheoretically [1,2] and experimentally [3-5]. It has been explained by an equilibrium thermodynamic
approach, but two related open problems can be highlighted:
(i) Does there exist a magnetic interaction or do there exist any other processes?
(ii) Do there exist also thermal effects?
Here, we introduce a non-equilibrium thermodynamic approach to respond to these questions. The
results obtained point out that:
(iii) The effect produced by the electromagnetic wave is just a consequence of the magnetic interaction;
(iv) The interaction of the electromagnetic wave causes also thermal effects, even if there have been
applied low frequency electromagnetic waves;
(v) The presence of the magnetic field generates a symmetry breaking in the Onsager's coefficients with
a related perturbation of the stationary state of the cancer.
Bibliography
[1] Lucia U., Grisolia G. Resonance in Thermal Fluxes Through Cancer Membrane. Atti
dell’Accademia Peloritana dei Pericolanti, 2020, 98, SC1-SC6, DOI 10.1478/AAPP.981SC1.
[2] Lucia U., Grisolia G. Second law efficiency for living cells, Frontiers in Bioscience 2017, 9, 270-
275, DOI 10.2741/s487.
[3] Lucia U., Grisolia G., Ponzetto A., Bergandi L., Silvagno F. Thermomagnetic resonance affects
cancer growth and motility, R. Soc. Open Sci. 2020, 7, 200299, DOI 10.1098/rsos.200299.
[4] Bergandi L., Lucia U., Grisolia G., Granata R., Gesmundo I., Ponzetto A., Paolucci E., Borchiellini
R., Ghigo E., Silvagno F. The extremely low frequency electromagnetic stimulation selective for
cancer cells elicits growth arrest through a metabolic shift, Biochimica et Biophysica Acta (BBA) -
Molecular Cell Research 2019, 1866, 1389-1397, DOI 10.1016/j.bbamcr.2019.05.006.
[5] Lucia U., Grazzini G., Montrucchio B., Grisolia G., Borchiellini R., Gervino G., Castagnoli C.,
Ponzetto A., Silvagno F. Constructal thermodynamics combined with infrared experiments to
evaluate temperature differences in cells, Sci. Rep. 2015, 5, 11587, DOI 10.1038/srep11587
Thermal resonance in living cells to control their heat exchange: Possible applications in cancer treatment
Full text linkIn the end of the second decade of 20th century, Warburg showed how cancer cells present a fermentative respiration process, related to a metabolic injury. Here, an analysis of the cell process is developed, based on its heat outflow, in order to control cancer progression. Engineering thermodynamics represents a powerful approach to develop this analysis. Indeed, the Engineering thermodynamic methods are introduced to analyse the bio-systems, in relation to heat outflow, in order to control this flux. Cells regulate their metabolisms by
energy and ion flows, and the heat flux is controlled by the convective interaction with their environment. The bio-thermodynamic characteristic frequency is introduced and it is evaluated by a classical heat transfer approach. Resonance forces natural behaviours of systems, and, here, it is introduced to control both the fluxes, through the cancer membrane, and the cellular metabolic processes. Consequently, the energy available to cancer, for its growth, is controlled, too. The result, experimentally proven, consists in the decrease of rate of cancer growth
Thermoeconomic analysis of Alessandria district: A case study for an engineering thermodynamic indicator for sustainability
Full text linkGross Domestic Product is usually the reference indicator to quantify the socio-economic consequences of the national policies due to its link to the increase of the nation well-being. But, it is used to evaluate the total monetary valuation of the productive systems, without any relation to the technological level or the environmental impact. These GDP characteristics represent the difficulties for sustainability to be realised. So, in this report, we wish to suggest a new indicator for the analysis of sustainability, with particular regards to the human wellbeing. This new indicator is based on the exergy analysis of dissipation and irreversibility. Moreover, energy is one of the fundamental drivers of the development, and of the economic growth. Last, in industrialized countries, the management of CO2 emissions represents one of the present imperative issues. Indeed, improving the energy efficiency and its rational use is one of the key economic strategies in order to achieve the target of moving towards a more sustainable development. The suggested indicator allows us to consider all these requests, for the progress towards a sustainable development, resulting a very interesting thermoeconomic quantity to be used by decision-makers. The Alessandria district is analysed as a case study
DEFINITION OF TIME: FROM THE SECOND TO CONSTRUCTAL LAW
Full text linkOne of the open problems in Physics is the analytical definition of time. This paper addresses a possible answer to this topic by proposing an analytical definition of time obtained by the Second Law of Thermodynamics and the Constructal Law approach
Irreversible Thermodynamics and Bioeconomy: Toward a Human-Oriented Sustainability
Full text linkThe present age is characterized by a very complex economic relationship among finance, technology, social needs, etc., which can be summarized in the word “sustainability.” The sustainable consumption and production policies represent the keys to realize sustainable development. But, the analysis of the carbon footprint data points out that the present economies are still carbon-consumption production. The reduction of greenhouse gasses emissions is based on a shift from fossil to renewable and bio-based industrial raw materials, with a related reorganization of the chains of the energy and manufacturing sectors. But, this requirement implies technological choices based on a sustainable measurement of their impacts on the ecological and economical contexts. So, social and economic requirements must also be taken into account by the decision-makers. Bioeconomy can represent a possible approach to deal with the requirements of the present time. But, new needs emerge in relation to sustainability. So, sustainable policies require new indicators, in order
to consider the link among economics, technologies, and social well-being. In this paper, an irreversible thermodynamic approach is developed, in order to introduce a thermoeconomic indicator, based on thermodynamic optimization methods, but also on socioeconomic and ecological evaluations. The entropy production rate is introduced in relation to the CO2 emission flows from human activities, and it is related to the income index, in order to consider the economic and social equity. This approach is of interest of the researchers in the field of econophysics, thermoeconomy, economics, and bioeconomy
Thermoeconomics: a holistic approach to technical development
Full text linkThe present days represent a crossroad in the history of humanity, and of the whole Earth. Complex dynamics both of growing the poverty distribution, and of increasing of ecological environmental and socio-economic degradation, are generating a difficult socio-economic system of despair from which it is very difficult to escape. Engineering and technological improvements can represent new possibilities for the renewal of the world, but a new indicator for the decision makers is required. The result, THDI, improves the usual HDI, by taking into account also the technical and ecological level by using the CO2 emissions and the sg quantities, related to the irreversibility of a process
Biofuels Analysis Based on the THDI Indicator of Sustainability
Full text linkEnergy resources, and their management, represent an open ongoing problem of our present days. An increasing interest in the analysis of the limits of fossil fuels’ use, and their
availability, is growing in order to find solutions to the undesired impact of some anthropic activities to the environment. So, nowadays, aThe current shift to renewable energy
resources has become a fundamental requirement. In this context, biofuels from microorganisms can represent a response to the requirement of reducing the environmental
impact, but also to generatinge new jobs. In this paper, the analysis of the biofuels from micro-organisms is developed by introducing the Thermodynamic Human Development
Index (THDI). In particular, we show how its performance can be improved by using the third-generation biofuels in the road transport sector, and how it increases by exploiting
biofuels derived from mutualistic species of some micro-organisms. The result consists in the fundamental role of the mutualistic behaviour of these species in order to
increase the overall sustainability
SHAPES AND HEAT TRANSFER IN CANCER: THE CONSTRUCTAL RESONANCE
Full text linkAny cell process requires energy, so a control of the energy conversion in the cell can represent a way to control the cell processes. Cells regulate their metabolisms by fluxes of energy and mass (ions included). The Constructal law is the thermodynamic approach which allows us to consider fluxes through the biosystems border, system shapes and interactions between biosystems and their environment in relation to the characteristic time (least time) of any process. Moreover, in relation to time, it is possible to consider the resonance phenomena. Resonance forces a natural behaviour of systems when a wave of a frequency related to the characteristic time income to a system. Here we introduce the Constructal frequency, the characteristic frequency of a system evaluated by a Constructal approach, in order to control the fluxes through the cancer membrane to force it towards a normal behaviour, by changing the concentrations of ions inside and outside the membrane itself. The consequence is a control of the metabolic processes in cells, but also a control of the energy available to cancer for its growth. In this way the cancer growth can be reduced
RESONANCE IN THERMAL FLUXES THROUGH CANCER MEMBRANE
Full text linkCancer represents one of the most important issues of the biomedical researches, which involve also other sciences, such as mathematics, physics, chemistry, biology, and engineering. In particular, a new thermophysical approach has been suggested and experimentally proved in the analysis of the growth behaviour of cancer cells. In this communication we introduce a theoretical evidence of the resonant behaviour of the heat exchange of the living cell. Last we summarise also the experimental results in support to this theoretical approach
The preoperative treatment of patients with heart valve prostheses undergoing oral and maxillofacial surgical interventions. Our protocol
No full textThe paper examines the prevention of hemorrhagic and bacterial endocarditis in patients with a prosthetic heart value and treated with oral anticoagulant therapy, undergoing oral and maxillo-facial surgery. The authors present a protocol personally adopted in hospital activity underlining the excellent results
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