1,720,982 research outputs found
Histologic Analysis of Zafirlukast's Effect on Capsule Formation Around Silicone Implants: Some Considerations
No full textWe have read with profound interest the article by Bastos
and colleagues entitled Histologic Analysis of Zafirlukast’s
Effect on Capsule Formation Around Silicone Implants.
We have truly enjoyed this study because it focuses on the
very important issue of ongoing research toward pharmacologic
therapy for the treatment of periprosthetic capsule
contracture. The latter has an incidence in the range of
0.5% to 50% [3]. Despite persistent clinical and laboratory
investigation, to date, no solution has been developed to
solve or prevent this problem
Assessing Interpectoral Nerve Block for Postoperative Pain Management in Reduction Mammaplasty Surgery
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Noninvasive three-dimensional quantitative analysis of volume and contour modifications after fat grafting procedures
No full textPrepubertal gynecomastia in two monozygotic twins with Peutz-Jeghers syndrome: Clinical and surgical management.
No full textWeight loss reduces interleukin-18 levels in obese women
No full textObesity is associated with an increased risk of developing atherosclerosis, which may be mediated, at least in part, by increased secretion of proinflammatory cytokines by adipose tissue. We examined the hypothesis that circulating levels of IL-18 were elevated in obese women and would be reduced by weight loss. In a sample of 40 obese (body mass index, 36.4 ± 3.1 kg/m2) women we found that plasma IL-18 levels were higher than in 40 normal weight control women (P < 0.01) and were positively associated with body weight (r = 0.46; P < 0.01) and visceral fat (waist to hip ratio; r = 0.39; P < 0.01). Caloric restriction-induced weight loss (≥10% of original weight) over 1 yr reduced IL-18 levels from 247 (204/309) to 147 (111/210) pg/ml (medians and 25%/75%; P < 0.01), positively associated with changes in body mass index and waist to hip ratio. In obese women, IL-18 levels are associated with body weight and abdominal fat deposition; weight loss is an important intervention to reduce IL-18 levels. IL-18 may be a novel cytokine operating in human obesity
Antioxidant property of Propofol in the ischemic and reperfused human skeletal muscle
No full textBackground. Oxygen-derived free radicals (ROS) are involved in tissue damage during muscle ischemia and reperfusion. Recent in vitro studies have demonstrated that a beneficial effect of Propofol (2,6 diisopropylphenol) lies on its free radical scavenging properties. The current study therefore examined whether Propofol is effective against the peroxidative damage induced by ROS in human skeletal muscle in the course of acute ischemia and reperfusion. Methods. A homogeneous group of patients (n=20) undergoing orthopedic surgery was subjected to handline tourniquet at 350 At for 60 min following by 20 min postischemic reperfusion. In skeletal muscle samples (m. vastus lat.) malondyaldeide (MDA), catalase (CAT) and uric acid levels were analyzed before tourniquet application, after 60 min of ischemia and then after 20 min following reperfusion. To ten subjects Propofol was supplied as bolus (5 mg/kg, body weight) during the ischemic interval. The tissue concentrations of MDA, CAT and Uric Acid were measured by spectrophotometric and phluorimetric methods comparing the values with the data obtained in an untreated group of patients (n = 10). Results. In all patients ischemic injury significantly increased MDA, and Uric Acid contents with a concomitant decrease in CAT levels. When reperfused the Propofol treated group showed an evident decrease in MDA Uric, and CAT gradients in respect of ischemic tissue. On the contrary rapid reoxygenation implies a highly significant increase in MDA as far as Uric Acid contents, while Catalase levels were unchanged. Conclusions. The current study demonstrated that in the human skeletal muscle Propofol attenuates the lipid peroxidation induced by ischemia and reperfusion and this beneficial action of Propofol is probably correlated with the free radical scavenging properties of this molecule
Effect of liposuction on insulin resistance and vascular inflammatory markers in obese women
No full textSummary Liposuction is one of the more common elective surgical procedures in the US and is supposed to be on the increase. There are no reported studies specifically addressing the metabolic sequelae of liposuction in obesity. The aim of the present study was to investigate the role of large-volume liposuction on insulin resistance and circulating inflammatory markers in obese people. Thirty healthy premenopausal obese (body mass index (BMI) from 30 to 45) and 30 age-matched normal weight (BMI<25) women were studied. In obese women, insulin sensitivity, as measured by the Homeostasis Model Assessment (HOMA = fasting plasma glucose £ fasting serum
insulin divided by 25), as well as serum adiponectin, the novel adipocytokine with insulin sensitising properties, were significantly lower, as compared with non obese women (p < 0.01); indicating insulin resistance; on the contrary, serum concentrations
of the proinflammatory cytokines IL-6, IL-18 and TNF-a, as well as the sensitive marker of inflammation C-reactive protein, were significantly higher (p<0.01). All obese women were submitted to a single large volume liposuction (superwet technique): the
mean aspirate volume was 3540 ml (range 2550–4670), corresponding to a net lipid loss of 2.7 +/- 0.7 kg (mean +/- SD). After six months of stable body weight after liposuction, women were less insulin resistant (p<0.05), had reduced concentrations of IL-6, IL-
18, TNF-a and CRP (p<0.05–0.02), and increased serum levels of adiponectin (p<0.02) and HDL-cholesterol (p<0.05). There was a significant correlation between the amount of fat aspirate and changes in HOMA (r = 0.28; p <0.05), TNF-a (r = 0.31; p<0:02), and adiponectin (r = 20:34; p<0:02), as well as between the decrease in
TNF-a and the increase in adiponectin after the surgical procedure (r =20:45; p<0.01). Our study demonstrates that liposuction is safe and free of metabolic sequelae in obese women, pending a careful screening of the patient. Moreover, it is associated with amelioration of insulin resistance and reduced circulating markers of
vascular inflammation which may help obese subjects to reduce their cardiovascular risk
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