1,721,250 research outputs found
"Il Movimento Cinque Stelle: Prospettive di ricerca a confronto", numero monografico della rivista "Quaderni di Scienza politica", XXIV, 3
No full textStudying Democracy in Europe: Conceptualization, Measurement and Indices
Full text linkGiven the academic and media salience of democracy and its measurement, in this contribution we take a closer look at the various existing datasets. For this purpose, in the first two sections we look at democratic conceptualization and measurement, and then focus on the most used datasets on democracy and assess them against the conceptual criteria illustrated in the first section. The third section focuses on the notion of quality of democracy and how it has advanced the understanding of contemporary democracies. The subsequent section illustrates changes in democratic scoring in European countries over the past 15 years. Our results show that democracy has not become more robust in European countries: on the contrary, several countries witnessed significant democratic deterioration. Furthermore, we show that - with the exception of Polity - the indexes analysed are highly correlated and therefore could be equally useful for an ongoing analysis of European democracies
Subculture e cambiamento politico-elettorale: il caso del Movimento Cinque Stelle in Veneto
No full textCetuximab continuation after first progression in metastatic colorectal cancer (CAPRI-GOIM): a randomized phase II trial of FOLFOX plus cetuximab versus FOLFOX
No full textBackground: Cetuximab plus chemotherapy is a first-line treatment option in metastatic KRAS and NRAS wild-type colorectal cancer (CRC) patients. No data are currently available on continuing anti-epidermal growth factor receptor (EGFR) therapy beyond progression. Patients and methods: We did this open-label, 1:1 randomized phase II trial at 25 hospitals in Italy to evaluate the efficacy of cetuximab plus 5-fluorouracil, folinic acid and oxaliplatin (FOLFOX) as second-line treatment of KRAS exon 2 wild-type metastatic CRC patients treated in first line with 5-fluorouracil, folinic acid and irinotecan (FOLFIRI) plus cetuximab. Patients received FOLFOX plus cetuximab (arm A) or FOLFOX (arm B). Primary end point was progressionfree survival (PFS). Tumour tissues were assessed by next-generation sequencing (NGS). This report is the final analysis. Results: Between 1 February 2010 and 28 September 2014, 153 patients were randomized (74 in arm A and 79 in arm B). Median PFS was 6.4 [95% confidence interval (CI) 4.7–8.0] versus 4.5 months (95% CI 3.3–5.7); [hazard ratio (HR), 0.81; 95% CI 0.58–1.12; P=0.19], respectively. NGS was performed in 117/153 (76.5%) cases; 66/117 patients (34 in arm A and 32 in arm B) had KRAS, NRAS, BRAF and PIK3CAwild-type tumours. For these patients, PFS was longer in the FOLFOX plus cetuximab arm [median 6.9 (95% CI 5.5–8.2) versus 5.3 months (95% CI 3.7–6.9); HR, 0.56 (95% CI 0.33–0.94); P =0.025]. There was a trend in better overall survival: median 23.7 [(95% CI 19.4–28.0) versus 19.8 months (95% CI 14.9–24.7); HR, 0.57 (95% CI 0.32–1.02); P=0.056]. Conclusions: Continuing cetuximab treatment in combination with chemotherapy is of potential therapeutic efficacy in molecularly selected patients and should be validated in randomized phase III trials
Update in Lung Cancer Molecular Pathology: Technological Advances and Clinical Practice
Full text linkThis Special Issue of eleven articles, including six original works and five reviews, demonstrates the modern heterogenous approach to lung cancer by means of various methodologies from international experts from various countries [...]
Challenges of a New Research Agenda
No full textThe concept of europeanization may have been, and perhaps still is, essentially contested as to its usefulness for the study of european politics. Yet few will dispute the claim that it has enjoyed increasing popularity in academic circles since the late 1990s. Scholars use the concept to assess the effectiveness of european-level policies at the domestic level, as well as to understand how new european opportunities and constraints affect national politics. This new research agenda thus focuses on changes in national political systems that can be attributed to the development of european regional integration, and brings together scholars from the fields of international relations, eu studies, and comparative politics.keywordseuropean integrationregional integrationeuropeanization researchdomestic levelcounterfactual reasoningthese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves
1992-2022: dalla destrutturazione del mercato elettorale alla ristrutturazione del sistema politico italiano
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