1,721,251 research outputs found
La Regolarità delle Pavimentazioni Stradali - Confronto tra un approccio deterministico (IRI) ed uno probabilistico
No full textI MATERIALI NELLA SOVRASTRUTTURA STRADALE
ATTI DEL VI CONVEGNO SIIV
Facoltà di Ingegneria, Ancona 14-16 Ottobre 199
Physiological Signaling and Structure of the HGF Receptor MET
Full text linkThe “hepatocyte growth factor” also known as “scatter factor”, is a multifunctional cytokine with the peculiar ability of simultaneously triggering epithelial cell proliferation, movement and survival. The combination of those proprieties results in the induction of an epithelial to mesenchymal transition in target cells, fundamental for embryogenesis but also exploited by tumor cells during metastatization. The hepatocyte growth factor receptor, MET, is a proto-oncogene and a prototypical transmembrane tyrosine kinase receptor. Inhere we discuss the MET molecular structure and the hepatocyte growth factor driven physiological signaling which coordinates epithelial proliferation, motility and morphogenesis
Qualifica prestazionale di un misto granulare di riciclo finalizzata al progetto di pavimentazioni industriali in calcestruzzo
No full textAtti del convegno internazionale VARIREI 2003 “Valorizzazione e riciclaggio di rifiuti industriali”. L’Aquila, 23-26 giugno 2003
The Tyrosine-phosphorylated Hepatocyte Growth Factor/Scatter Factor Receptor Associates with Phosphatidylinositol 3-kinase
No full textCharacterization of the three-dimensional linear viscoelastic behavior of asphalt concrete mixtures
No full textMechanistic-empirical pavement design methods typically require the identification of the complex Young’s modulus and Poisson’s ratio for the characterization of bituminous layers. However, since in small deformation the frequency-dependent shear and bulk responses of an isotropic body are decoupled, the complex shear and bulk moduli are generally considered fundamental response functions. The objective
of this study was to perform the experimental characterization of the three-dimensional response of asphalt mixtures in the linear viscoelastic domain, through the simultaneous measurement of the complex moduli E⁄, K⁄ and G⁄ and the complex Poisson’s ratio m⁄. The testing program consisted of cyclic compression and cyclic tension–compression uniaxial tests on cylindrical specimen, with the measurement of
both axial and transverse strain. In particular, frequency sweeps were carried out at temperatures between 0, and 40 C and at axial strain levels between 15 and 60 le. Experimental results highlighted that, for the tested mixture, the time–temperature superposition principle was applicable to both the bulk and shear response, and consequently to the axial response. E⁄ and G⁄ showed very similar trends in terms of both stiffness moduli and loss angle, whereas K⁄ values highlighted smaller frequency dependence. The time–temperature superposition principle was also applicable to m⁄ whose master curves can be qualitatively described using the local approximation to the Kramers–Kronig relations. Results suggest that the simultaneous assessment of bulk and shear response may be a useful tool for the performance characterization of asphalt mixtures
Acylated and unacylated ghrelin administration to blunt muscle wasting
No full textPurpose of review: Muscle wasting is a comorbidity often associated with a wide range of disorders that severely affects patient prognosis and quality of life. Ghrelin, through its receptor GHSR-1a, stimulates appetite and growth hormone (GH) release. Several studies indicate that ghrelin administration is a valid treatment for cachexia because it improves muscle mass and function, likely by restoring a positive energy balance. RECENT FINDINGS: In addition to its GHSR-1a-mediated effects on muscle mass, ghrelin acts directly on skeletal muscle, wherein it exerts a protective activity against muscle wasting. This direct activity is independent of GHSR-1a and is shared by the unacylated form of ghrelin, which does not bind GHSR-1a and is devoid of the effects on appetite and GH release. SUMMARY: Both the acylated and unacylated forms of ghrelin might have therapeutic potential for the treatment of skeletal muscle wasting. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins
Purification and characterization of Human Erythrocyte Phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and Phosphatidylinositol(3)-monophosphate 4-kinase are distinct enzymes
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