1,721,328 research outputs found

    On the seismic analysis of structures with friction pendulum isolators subjected to horizontal and vertical ground motions

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    This research focuses on the different modeling approaches for the simulation of the seismic response of structures with friction pendulum isolation systems. The behavior of such systems is strongly affected by several parameters, as for example the friction coefficient and the axial load. The latter has a particular importance in presence of seismic actions characterized by the simultaneous presence of high horizontal and vertical accelerations. To study these aspects several nonlinear dynamic analyses have been performed considering a two degree of freedom model isolated at the base and subjected to recorded horizontal and vertical ground motions. The response of the isolation systems have been studied through different models, starting by the more simple ones based on constant friction coefficient to the more complex ones based on a friction coefficient varying as a function of sliding velocity and axial force. The records have been also applied considering increasing values of intensity, in order to determine the collapse acceleration. The results have allowed to compare the different models and to study the effect of the vertical seismic component on the response of the isolators

    Is it time to develop a robotic difficulty score system?

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    Considerations about the use of scores of difficulty in the practice of robotic liver resection

    Review article: liver transplantation for HCC. Treatment options on the waiting list

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    The most widely adopted criteria to admit and maintain patients with HCC and cirrhosis in the waiting list for liver transplantation are the Milano criteria, consisting in the presence of a single tumour ≤ 5 cm in diameter or up to three tumours, none exceeding 3 cm in diameter. Since the average time to transplantation has become longer than 10-12 months in most European and American Centers, the exclusion from the list during the waiting period due to increase of the neoplasm over the established criteria is not uncommon at present. It is mandatory, therefore, to seek an effective therapeutic strategy for patients with HCC waiting for transplantation. Surgical resection and eventual subsequent salvage transplantation seems a cost-effective strategy in resectable HCC. In unresectable neoplasms both transarterial chemoembolization and percutaneous ablation techniques are currently used and one or the other are chosen according to individual applicability, limitations and specific risks. However, although positive trends were reported, no definitive evidence has been produced so far about their efficacy in increasing patient's survival and decreasing tumour recurrence rates after transplantation. Adult-to-adult living donor liver transplantation is one possible way to shorten the waiting list, but this strategy involves important ethical implications. At present it appears justified to take it into consideration only if the waiting time for cadaveric OLT is expected to exceed 7 months. A more general and definitive attempt to overcome problems related to long waiting times for patients with HCC and relatively preserved hepatic function has been introduced in the USA very recently and consists in prioritizing patients with HCC. However, the overall efficacy of this approach will be established only in some years
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