1,721,210 research outputs found
Definizione citogenetica del carcinoma sarcomatoide del rene e dei tumori uroteliali delle alte vie urinarie
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Connective tissue, Ehlers-Danlos syndrome(s), and head and cervical pain.
No full textEhlers-Danlos syndrome (EDS) is an umbrella term for a growing group of hereditary disorders of the connective tissue mainly manifesting with generalized joint hypermobility, skin hyperextensibility, and vascular and internal organ fragility. In contrast with other well known heritable connective tissue disorders with severe cardiovascular involvement (e.g., Marfan syndrome), most EDS patients share a nearly normal life span, but are severely limited by disabling features, such as pain, fatigue and headache. In this work, pertinent literature is reviewed with focus on prevalence, features and possible pathogenic mechanisms of headache in EDSs. Gathered data are fragmented and generally have a low level of evidence. Headache is reported in no less than 1/3 of the patients. Migraine results the most common type in the hypermobility type of EDS. Other possibly related headache disorders include tension-type headache, new daily persistent headache, headache attributed to spontaneous cerebrospinal fluid leakage, headache secondary to Chiari malformation, cervicogenic headache and neck-tongue syndrome, whose association still lacks of reliable prevalence studies. The underlying pathogenesis seems complex and variably associated with cardiovascular dysautonomia, cervical spine and temporomandibular joint instability/dysfunction, meningeal fragility, poor sleep quality, pain-killer drugs overuse and central sensitization. Particular attention is posed on a presumed subclinical cervical spine dysfunction. Standard treatment is always symptomatic and usually unsuccessful. Assessment and management procedures are discussed in order to put some basis for ameliorating the actual patients' needs and nurturing future research.Ehlers–Danlos syndrome (EDS) is an umbrella term for a growing group of hereditary disorders of the connective
tissue mainly manifesting with generalized joint hypermobility, skin hyperextensibility, and vascular and internal
organ fragility. In contrast with other well known heritable connective tissue disorders with severe cardiovascular
involvement (e.g., Marfan syndrome), most EDS patients share a nearly normal life span, but are severely limited
by disabling features, such as pain, fatigue and headache. In this work, pertinent literature is reviewed with focus
on prevalence, features and possible pathogenic mechanisms of headache in EDSs. Gathered data are
fragmented and generally have a low level of evidence. Headache is reported in no less than 1/3 of the patients.
Migraine results the most common type in the hypermobility type of EDS. Other possibly related headache
disorders include tension-type headache, new daily persistent headache, headache attributed to spontaneous
cerebrospinal fluid leakage, headache secondary to Chiari malformation, cervicogenic headache and neck–
tongue syndrome, whose association still lacks of reliable prevalence studies. The underlying pathogenesis
seems complex and variably associated with cardiovascular dysautonomia, cervical spine and temporomandibular
joint instability/dysfunction, meningeal fragility, poor sleep quality, pain-killer drugs overuse and central
sensitization. Particular attention is posed on a presumed subclinical cervical spine dysfunction. Standard
treatment is always symptomatic and usually unsuccessful. Assessment and management procedures are
discussed in order to put some basis for ameliorating the actual patients' needs and nurturing future researc
Uveal melanoma: a model for exploring fundamental cancer biology.
No full textRecent studies have revealed that that uveal melanoma and cutaneous melanoma are remarkably different diseases. Uveal Melanoma: A Model for Exploring Fundamental Cancer Cell Biology provides insights into some of these differences and summarizes recent developments regarding the basic research on biology and metastasis of uveal melanoma. It is a compendium of 20 chapters written by an international collection of authors who are currently involved with uveal melanoma research. They explore current research and thinking on the pathobiology of and expansion of treatment options for, this type of melanoma. Illustrations include characterization of genomic uveal melanoma cell lines
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