3,415 research outputs found
Fattori di controllo della angiogenesi: modificazioni dei valori ematici di VEGF, FGFB ed Endostatina nel post- operatorio
No full textOpen issues in genetic programming
No full textIt is approximately 50 years since the first computational experiments were conducted in what has become known today as the field of Genetic Programming (GP), twenty years since John Koza named and popularised the method, and ten years since the first issue appeared of the Genetic Programming & Evolvable Machines journal. In particular, during the past two decades there has been a significant range and volume of development in the theory and application of GP, and in recent years the field has become increasingly applied. There remain a number of significant open issues despite the successful application of GP to a number of challenging real-world problem domains and progress in the develop- ment of a theory explaining the behavior and dynamics of GP. These issues must be addressed for GP to realise its full potential and to become a trusted mainstream member of the computational problem solving toolkit. In this paper we outline some of the challenges and open issues that face researchers and practitioners of GP. We hope this overview will stimulate debate, focus the direction of future research to deepen our understanding of GP, and further the development of more powerful problem solving algorithms.Science Foundation IrelandEmbargo until April 2011 - AV April 2011
ke - AS 04/11/2010
ab - TS 18.11.1
Comparison of Gonioscopy-assisted Transluminal Trabeculotomy Versus Trabeculectomy With Mitomycin C in Patients With Open-angle Glaucoma
No full textPrecis: Trabeculectomy (TRAB) lowers the intraocular pressure (IOP) more than gonioscopy-assisted transluminal trabeculotomy (GATT) at 18 months, with a reduction in IOP of 30% or more and a significant reduction in the number of glaucoma medications compared with baseline. Purpose: To compare the IOP-lowering efficacy of GATT with mitomycin-C augmented TRAB in patients with uncontrolled open-angle glaucoma. Methods: Single-center, retrospective, comparative cohort study. One hundred ten consecutive patients (110 eyes) underwent GATT (n=61) or TRAB (n=49). The primary outcome measure was IOP reduction, defined as a percentage decrease >= 30% and absolute IOP <= 18 mm Hg at 18 months with (qualified) or without (complete) medications. Secondary outcomes were visual field change, number of glaucoma medications, complications, and reintervention. Results: The mean +/- SD baseline IOP was 30.04 +/- 7.5 and 27.59 +/- 4.70 (P=0.072) with the mean number of medications of 3.08 +/- 0.73 and 2.92 +/- 0.91 (P=0.310) in TRAB and GATT, respectively. At 18 months, the mean +/- SD IOP was 15.26 +/- 3.47 mm Hg and 12.48 +/- 4.58 mm Hg after GATT and TRAB, respectively (P=0.002). The percentage of IOP lowering from baseline was 56.05 +/- 17.72 after TRAB and 42.04 +/- 15.56 after GATT (P<0.001). Percentages of complete and qualified success were 59% and 27% after TRAB and 46% and 31% after GATT (P=0.353). No change in visual field loss was observed in both groups. The mean reduction in medications was 2.3 +/- 1.4 and 2.1 +/- 1.5 in TRAB and GATT, respectively (P=0.493). The most frequent complication after TRAB was hypotony and after GATT hyphema. Reintervention occurred in 8.2% of cases after TRAB and in 14.8% after GATT (P=0.341). Conclusions: IOP lowering was greater after TRAB than after GATT at 18 months with a significant reduction in the number of medications after both procedures. Complications and reintervention occurred equally in both groups but differed in type
Comparison of Gonioscopy-assisted Transluminal Trabeculotomy Versus Trabeculectomy with Mitomycin C in Patients with Open-angle Glaucoma
No full textPrcis: Trabeculectomy (TRAB) lowers the intraocular pressure (IOP) more than gonioscopy-assisted transluminal trabeculotomy (GATT) at 18 months, with a reduction in IOP of 30% or more and a significant reduction in the number of glaucoma medications compared with baseline.
Purpose: To compare the IOP-lowering efficacy of GATT with mitomycin-C augmented TRAB in patients with uncontrolled open-angle glaucoma.
Methods: Single-center, retrospective, comparative cohort study. One hundred ten consecutive patients (110 eyes) underwent GATT (n=61) or TRAB (n=49). The primary outcome measure was IOP reduction, defined as a percentage decrease ≥30% and absolute IOP≤18 mm Hg at 18 months with (qualified) or without (complete) medications. Secondary outcomes were visual field change, number of glaucoma medications, complications, and reintervention.
Results: The mean±SD baseline IOP was 30.04±7.5 and 27.59±4.70 (P=0.072) with the mean number of medications of 3.08±0.73 and 2.92±0.91 (P=0.310) in TRAB and GATT, respectively. At 18 months, the mean±SD IOP was 15.26±3.47 mm Hg and 12.48±4.58 mm Hg after GATT and TRAB, respectively (P=0.002). The percentage of IOP lowering from baseline was 56.05±17.72 after TRAB and 42.04±15.56 after GATT (P<0.001). Percentages of complete and qualified success were 59% and 27% after TRAB and 46% and 31% after GATT (P=0.353). No change in visual field loss was observed in both groups. The mean reduction in medications was 2.3±1.4 and 2.1±1.5 in TRAB and GATT, respectively (P=0.493). The most frequent complication after TRAB was hypotony and after GATT hyphema. Reintervention occurred in 8.2% of cases after TRAB and in 14.8% after GATT (P=0.341).
Conclusions: IOP lowering was greater after TRAB than after GATT at 18 months with a significant reduction in the number of medications after both procedures. Complications and reintervention occurred equally in both groups but differed in type
The distributed production system of the SuperB project: description and results
No full textThe SuperB experiment needs large samples of MonteCarlo simulated events in order to finalize the detector design and to estimate the data analysis performances. The requirements are beyond the capabilities of a single computing farm, so a distributed production model capable of exploiting the existing HEP worldwide distributed computing infrastructure is needed. In this paper we describe the set of tools that have been developed to manage the production of the required simulated events. The production of events follows three main phases: distribution of input data files to the remote site Storage Elements (SE); job submission, via SuperB GANGA interface, to all available remote sites; output files transfer to CNAF repository. The job workflow includes procedures for consistency checking, monitoring, data handling and bookkeeping. A replication mechanism allows storing the job output on the local site SE. Results from 2010 official productions are reported
The effect of ET1-CTGF mediated pathway on the accumulation of extracellular matrix in the trabecular meshwork and its contribution to the increase in IOP
No full textPurpose: Excessive accumulation of extracellular matrix (ECM) in the trabecular meshwork (TM) increases resistance to the outflow of aqueous humor, which inevitably contributes to the elevation of intraocular pressure (IOP) in primary open angle glaucoma (POAG). Endothelin 1 (ET-1), a potent vasoconstrictor peptide, is reported to enhance profibrotic processes in multiple organs like liver, lung, and kidney tissues, which also significantly increases aqueous humor in POAG patients. Here we tested the hypothesis that ET-1 plays a key role in excessive accumulation in the trabecular meshwork and increase in IOP.
Methods: To test the effect of ET-1 on expression of fibronectin (FN), collagen type IV (COL-IV) and its receptor pathway, cultured human TM cells (HTMCs) were treated with ET-1, ET-1+ ETAR antagonist (BQ123) or ETBR antagonist (BQ788). The protein expression levels of FN, and COL-IV were evaluated by western-blot. A time course effect of ET-1 on the transcription level of the connective tissue growth
factor (CTGF) was investigated by qRT-PCR. Next, we down regulated the transcription level of CTGF by its antisense oligodeoxynucleotide sequence and then tested the expression levels of FN, and COL-IV. Lastly, we observed the effect of ET1 on IOP changes, expression of FN, and COL-IV in an ex-vivo model of cultured anterior eye segment.
Results: In cultured HTMs, the expression of FN and COL-IV was significantly increased after ET-1 treatment, and this could be blocked by ETAR antagonist (BQ123) but not ETBR antagonist (BQ788). Further, the CTGF mRNA level also
increased significantly and reached the top level at 48h after ET-1 treatment. However, the induced ET-1 increased the expression of FN and COL-IV in HTMCs and could be reversed by the downregulation of CTGF. In an ex-vivo model,
incensement of FN and COL-IV expression were observed too after ET-1 perfusion. Furthermore, IOP significantly increased after ET-1 administration. Nevertheless, this could be decreased by the ETAR antagonist (BQ123) but not the ETBR antagonist (BQ788).
Conclusions: These results indicate that ET-1 in aqueous humor could lead to the abnormal synthesis of FN and COL-IV via the ETA-CTGF pathway which could result in the accumulation of ECM in trabecular meshwork and incensement of IOP
Cataract surgery and IOP: a systematic review of randomised controlled trials
No full text© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022Purpose: Cataract and glaucoma are two of the most common ocular comorbidities. Cataract surgery has been shown to influence intra-ocular pressure (IOP) in patients with glaucoma; nevertheless, the extent of this effect remains controversial, especially in patients with open-angle glaucoma (OAG). The aim of this review is to determine the real effect of cataract surgery on IOP change in patients with OAG, focusing on data retrieved from randomised controlled trials (RCTs).
Methods: A systematic review was performed, including six different RCTs that studied the net effect of cataract surgery on IOP. Eligibility criteria required a full washout from hypotensive therapy, allowing accurate measurement of unmedicated IOP, both before and after surgery.
Results: Included studies revealed a consistent reduction on IOP occurring after surgery, varying between 4.1 and 8.5 mmHg depending on the RCT. There was also a decrease in the number of glaucoma medications, with a mean reduction of 0.2-1.0 agents postoperatively. Evaluation of adverse outcomes of cataract surgery showed a very favourable safety profile.
Conclusion: Although the role of cataract surgery in the algorithm of glaucoma treatment remains to be established, this review highlights a consistent decrease on IOP following surgery and a reduced dependency on glaucoma medications. Potential downgrade in medication can thus be considered in well-controlled glaucoma patients after phacoemulsification.info:eu-repo/semantics/publishedVersio
Lab rock core studies of the Ufimian horizon as a prior step to displacement experiments with steam
No full text© Published under licence by IOP Publishing Ltd. The author in this paper determined the coefficient of porosity from well log data and carried on a study of core samples using X-ray microtomography and traditional methods. A method was elaborated and later tested for measurement of porosity of samples taken from the production interval of shallow super viscous oil deposits of the Tatarstan's Republic. Also determination of mineralogical composition and characteristics of the reservoir rock for application to future steam flooding experiments. On the basis of the data obtained, was concluded which of the methods gives the most reliable information on this of the reservoir rock under study
Clones of Interstitial Cells From Bovine Aortic Valve Exhibit Different Calcifying Potential When Exposed to Endotoxin and Phosphate
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