21,493 research outputs found
Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes
No full textOxidative stress contributes to diabetic cardiomyopathy. This study explored the role of the NADPH oxidase Nox4 as a source of reactive oxygen species (ROS) involved in the development of diabetic cardiomyopathy. Phosphorothioated antisense (AS) or sense (S) oligonucleotides for Nox4 were administered for 2 wk to rats made diabetic by streptozotocin. NADPH oxidase activity, ROS generation, and the expression of Nox4, but Nox1 or Nox2, were increased in left ventricular tissue of the diabetic rats. Expression of molecular markers of hypertrophy and myofibrosis including fibronectin, collagen, α-smooth muscle actin, and β-myosin heavy chain were also increased. These parameters were attenuated by the administration of AS but not S Nox4. Moreover, the impairment of contractility observed in diabetic rats was prevented in AS-but not S-treated animals. Exposure of cultured cardiac myocytes to 25 mM glucose [high glucose (HG)] increased NADPH oxidase activity, the expression of Nox4, and molecular markers of cardiac injury. These effects of HG were prevented in cells infected with adenoviral vector containing a dominant negative form of Nox4. This study provides strong evidence that Nox4 is an important source of ROS in the left ventricle and that Nox4-derived ROS contribute to cardiomyopathy at early stages of type 1 diabetes. © 2012 by the American Physiological Society.Ago T, 2010, CIRC RES, V106, P1253, DOI 10.1161-CIRCRESAHA.109.213116; Aneja A, 2008, AM J MED, V21, P748; Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152-physrev.00044.2005; Block K, 2009, P NATL ACAD SCI USA, V106, P14385, DOI 10.1073-pnas.0906805106; Bondi CD, 2010, J AM SOC NEPHROL, V21, P93, DOI 10.1681-ASN.2009020146; Boudina S, 2007, CIRCULATION, V115, P3213, DOI 10.1161-CIRCULATIONAHA.106.679597; Cave A, 2009, CURR OPIN PHARMACOL, V9, P208, DOI 10.1016-j.coph.2008.10.001; Cucoranu I, 2005, CIRC RES, V97, P900, DOI 10.1161-01.RES.0000187457.24338.3D; Dikalov SI, 2008, FREE RADICAL BIO MED, V45, P1340, DOI 10.1016-j.freeradbiomed.2008.08.013; Dyntar D, 2006, J CLIN ENDOCR METAB, V91, P1961, DOI 10.1210-jc.2005-1904; Eid AA, 2009, DIABETES, V58, P1201, DOI 10.2337-db08-1536; Fiordaliso F, 2004, J MOL CELL CARDIOL, V37, P959, DOI 10.1016-j.yjmcc.2004.07.008; Gao L, 2009, CARDIOVASC RES, V82, P9, DOI 10.1093-cvr-cvp031; Geiszt M, 2004, J BIOL CHEM, V279, P51715, DOI 10.1074-jbc.R400024200; Gorin Y, 2005, J BIOL CHEM, V280, P39616, DOI 10.1074-jbc.M502412200; Gorin Y, 2004, BIOCHEM J, V381, P231, DOI 10.1042-BJ20031614; Gorin Y, 2003, AM J PHYSIOL-RENAL, V285, pF219, DOI 10.1152-ajprenal.00414.2002; Griendling KK, 2004, HEART, V90, P491, DOI 10.1136-hrt.2003.029397; Guzik TJ, 2002, CIRCULATION, V105, P1656, DOI 10.1161-01.CIR.0000012748.58444.08; Hecker L, 2009, NAT MED, V15, P1077, DOI 10.1038-nm.2005; Infanger DW, 2010, CIRC RES, V106, P1763, DOI 10.1161-CIRCRESAHA.109.213025; Kim NH, 2006, AM J PHYSIOL-RENAL, V290, pF741, DOI 10.1152-ajprenal.00313.2005; Kuroda J, 2010, P NATL ACAD SCI USA, V107, P15565, DOI 10.1073-pnas.1002178107; Lassegue B, 2003, AM J PHYSIOL-REG I, V285, pR277, DOI 10.1152-ajpregu.00758.2002; Li JM, 2010, DIABETES, V59, P1528, DOI 10.2337-db09-1057; Mann DL, 2007, NEW ENGL J MED, V356, P2644, DOI 10.1056-NEJMcibr072068; Martyn KD, 2006, CELL SIGNAL, V18, P69, DOI 10.1016-j.cellsig.200503.023; Poornima IG, 2006, CIRC RES, V98, P596, DOI 10.1161-01.RES.0000207406.94146.c2; San Martin A, 2007, AM J PHYSIOL-HEART C, V292, pH2073, DOI 10.1152-ajpheart.00943.2006; Serrander L, 2007, BIOCHEM J, V406, P105, DOI 10.1042-BJ20061903; Song Ye, 2007, Rev Diabet Stud, V4, P159, DOI 10.1900-RDS.2007.4.159; Spurney CF, 2008, NEUROMUSCULAR DISORD, V18, P371, DOI 10.1016-j.nmd.2008.03.008; Thandavarayan RA, 2009, AM J PHYSIOL-HEART C, V297, pH911, DOI 10.1152-ajpheart.00124.2009; Von Lohneysen K, 2008, J BIOL CHEM, V283, P35273, DOI 10.1074-jbc.M804200200; Wang Jianxun, 2006, Review of Diabetic Studies, V3, P108, DOI 10.1900-RDS.2006.3.108; Wendt MC, 2005, FREE RADICAL BIO MED, V39, P381, DOI 10.1016-j.freeradbiomed.2005.03.020; Zhang M, 2010, P NATL ACAD SCI USA, V107, P18121, DOI 10.1073-pnas.100970010729323
Protecting Animals 36: Author Witi Ihimaera
No full textIn this very special episode of Knowing Animals I am joined by beloved New Zealand author Witi Ihimaera. Witi has written many books featuring nonhuman animals. He offers us a non-colonial lens through which to think about the human/nonhuman relationship
ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice
No full textMatrix protein accumulation is a prominent feature of diabetic nephropathy that contributes to renal fibrosis and decline in renal function. The pathogenic mechanisms of matrix accumulation are incompletely characterized. We investigated if the matrix metalloprotease a disintegrin and metalloprotease1 7 (ADAM17), known to cleave growth factors and cytokines, is activated in the kidney cortex of OVE26 type 1 diabetic mice and the potential mechanisms by which ADAM17 mediates extracellular matrix accumulation. Protein expression and activity of ADAM17 were increased in OVE26 kidney cortex. Using a pharmacological inhibitor to ADAM17, TMI-005, we determined that ADAM17 activation results in increased type IV collagen, Nox4, and NADPH oxidase activity in the kidney cortex of diabetic mice. In cultured mouse proximal tubular epithelial cells (MCTs), high glucose increases ADAM17 activity, Nox4 and fibronectin expression, cellular collagen content, and NADPH oxidase activity. These effects of glucose were inhibited when cells were pretreated with TMI-005 and-or transfected with small interfering ADAM17. Collectively, these data indicate a novel mechanism whereby hyperglycemia in diabetes increases extracellular matrix protein expression in the kidney cortex through activation of ADAM17 and enhanced oxidative stress through Nox enzyme activation. 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STUDY OF CAPILLARY TRACKING DETECTORS WITH POSITION-SENSITIVE PHOTOMULTIPLIER READOUT
No full textMeasurements have been carried out on light yield and attenuation length in glass capillaries filled with new liquid scintillators (LS) and compared with analogous measurements made on 0.5 mm diameter plastic fibres Kuraray SCSF-38 and 3HF. It is found that, at a distance of 1 m, the light output in the capillary filled with green LS based on 1-methylnaphthalene doped with a new dye 3M15 is greater by a factor of 2 to 3 than for plastic fibres. A tracking detector consisting of a capillary bundle read out by a 100 channel position-sensitive microchannel plate photomultiplier (2MCP-100) has been built and tested in the laboratory using a cosmic ray trigger. A comparison has been made between the performance of such a detector and that of a similar one, read out by a 96 channel Philips XP1724/A photomultiplier. It was found that a bundle made of 20 mu m diameter capillaries with a tapered end giving a magnification of 2.56, filled with the new IPN+3M15 liquid scintillator, read out by the 2MCP-100, provides a space resolution of sigma = 170 mu m, a two-track resolution of the same value and a hit density of n = 1.9/mm for tracks crossing the detector at a distance of 20 cm from the photocathode. If the same detector is read out by the Philips XP1724/A, the space resolution becomes 200 mu m, the two-track resolution 600 mu m and the hit density n = 1.7/mm. The worse performance in the latter case is caused by the larger crosstalk compared with that of the 2MCP-100 PSPM, The results indicate that a LS-filled capillary detector is a very promising device for fast fibre tracking
I Think I Am Philip K. Dick
No full textFor years, noted writer Laurence A. Rickels often found himself compared to novelist Philip K. Dickthough in fact Rickels had never read any of the science fiction writers work. When he finally read his first Philip K. Dick novel, while researching for his recent book The Devil Notebooks , it prompted a prolonged immersion in Dicks writing as well as a recognition of Rickelss own long-documented intellectual pursuits. The result of this engagement is I Think I Am: Philip K. Dick , a profound thought experiment that charts the wide relevance of the pulp sci-fi author and paranoid visionary. I Think I Am: Philip K. Dick explores the science fiction authors meditations on psychic reality and psychosis, Christian mysticism, Eastern religion, and modern spiritualism. Covering all of Dicks science fiction, Rickels corrects the lack of scholarly interest in the legendary Californian author and, ultimately, makes a compelling case for the philosophical and psychoanalytic significance of Philip K. Dicks popular and influential science fiction.Intro -- Contents -- Introjection -- Part I -- Endopsychic Allegories -- Schreber Guardian -- Belief System Surveillance -- Part II -- Deeper Problems -- Veil of Tears -- Go West -- Dick Manfred -- Timing -- Glimmung -- Part III -- Spiritualism Analogy -- Imitating the Dead -- Indexical Layer -- Ilse -- Hammers and Things -- Crucifictions -- Over There -- Martyrology -- Can't Live, Can't Live -- Lola -- Umwelt, Mitwelt, and Eigenwelt -- Outer Race -- The German Introject -- Part IV -- Materialism, Idealism, and Cybernetics -- Startling Stories -- A Couple of Years -- Android Empathy -- Homunculus and Robot -- ALL OF YOU ARE DEAD. I AM ALIVE. -- Go with the Flow -- Part V -- Room for Thought -- Caduceus -- Jump -- Still -- A Wake -- Spätwerk -- Let the Dead Be -- Play Bally -- Das Hund -- Notes -- BibliographyFor years, noted writer Laurence A. Rickels often found himself compared to novelist Philip K. Dickthough in fact Rickels had never read any of the science fiction writers work. When he finally read his first Philip K. Dick novel, while researching for his recent book The Devil Notebooks , it prompted a prolonged immersion in Dicks writing as well as a recognition of Rickelss own long-documented intellectual pursuits. The result of this engagement is I Think I Am: Philip K. Dick , a profound thought experiment that charts the wide relevance of the pulp sci-fi author and paranoid visionary. I Think I Am: Philip K. Dick explores the science fiction authors meditations on psychic reality and psychosis, Christian mysticism, Eastern religion, and modern spiritualism. Covering all of Dicks science fiction, Rickels corrects the lack of scholarly interest in the legendary Californian author and, ultimately, makes a compelling case for the philosophical and psychoanalytic significance of Philip K. Dicks popular and influential science fiction.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Liftings for noncomplete probability spaces
No full textThe current state of knowledge concerning liftings for noncomplete probability spaces is discussed. This is a somewhat expanded version of the author's talk given at the 1991 Summer Conference on General Topology and Applications in Honor of Mary Ellen Rudin and Her Work.PT: S; CR: BURKE MR, IN PRESS P AM MATH S BURKE MR, 1991, ISRAEL J MATH, V73, P33 BURKE MR, 1992, ISRAEL J MATH, V79, P289 CARLSON T, THEOREM LIFTING CHRISTENSEN JPR, 1974, TOPOLOGY BOREL STRUC FREMLIN DH, 1989, HDB BOOLEAN ALGEBRAS, P877 INOESCUTULCEA A, 1966, 5TH P BERK S MATH ST, V2 IONESCUTULCEA A, 1967, CONTRIBUTIONS PROB 1, P63 IONESCUTULCEA A, 1969, TOPICS THEORY LIFTIN JECH TJ, 1978, SET THEORY JOHNSON RA, 1980, P AM MATH SOC, V80, P234 JUST W, IN PRESS T AM MATH S KUPKA J, 1983, INDIANA U MATH J, V32, P717 LOSERT V, 1983, LNM, V1080, P95 MAHARAM D, 1958, P AM MATH SOC, V9, P987 SHELAH S, 1983, ISRAEL J MATH, V45, P90 TALAGRAND M, 1982, P AM MATH SOC, V84, P379 VONNEUMANN J, 1931, CRELLES J MATH, V165, P109; NR: 18; TC: 0; J9: ANN N Y ACAD SCI; PG: 4; GA: BZ86BSource type: Electronic(1
The AM Canum Venaticorum binary SDSS J173047.59+554518.5
No full textThe AM Canum Venaticorum (AM CVn) binaries are a rare group of hydrogen-deficient, ultrashort period, mass-transferring white dwarf binaries and are possible progenitors of Type Ia supernovae. We present time-resolved spectroscopy of the recently discovered AM CVn binary SDSS J173047.59+554518.5. The average spectrum shows strong double-peaked helium emission lines, as well as a variety of metal lines, including neon; this is the second detection of neon in an AM CVn binary, after the much brighter system GP Com. We detect no calcium in the accretion disc, a puzzling feature that has been noted in many of the longer period AM CVn binaries. We measure an orbital period, from the radial velocities of the emission lines, of 35.2 ± 0.2 min, confirming the ultracompact binary nature of the system. The emission lines seen in SDSS J1730 are very narrow, although double-peaked, implying a low-inclination, face-on accretion disc; using the measured velocities of the line peaks, we estimate i ≤ 11°. This low inclination makes SDSS J1730 an excellent system for the identification of emission lines
Freedom of choice or force of circumstance? : Eastern European sex-workers in the Republic of Cyprus ; paper for the conference 'Alltag der Globalisierung. Perspektiven einer transnationalen Anthropologie', January 16-18, 2003, Institute of Cultural Anthropology and European Ethnology, Johann Wolfgang Goethe University, Frankfurt am Main
No full textThis paper focuses on Eastern European migrants who, since the beginning of the 1990s, are entering the Republic Cyprus as “artistes”. This is a visa permit status as well as an euphemism for short-term work permits in the local sex industry. In addition to exploring the migrational experiences of these women and their living and working conditions in the Republic of Cyprus, the paper reconstructs, empirically and analyt ically, the connection between immigration and the local sex industry. Here, several categories of social actors and institutions in Cyprus are actively involved. The rhetoric of government representatives, entrepreneurs and clients in the sex business on the one hand is contrasted with the discourse of local NGO representatives concerned with immigrants’ rights on the other hand. The paper comes to the conclusion that all of these discursive positions ultimately do not do justice to the complex process of decisionmaking that women undergo who migrate into the sex industry. Either, freedom of choice is emphasized – such as by entrepreneurs and the government – or the domination of women – as in the public statements of the NGO. In order to analyze the ambivalent tension between freedom of choice and submission to force by which the women’s decision is characterized, the author employs Michel Foucault’s concept of governmentality, which describes forms of political regulation that use the individual’s freedom of action as an instrument to exercise power
Anleitung Zu der Frantzösischen Sprach/ Begreiffend was anfänglich/ diese Sprach zuerlernen/ am allernöhtigsten sey: Der Jugend Teutscher Nation: zu besten verfertiget
No full textANLEITUNG ZU DER FRANTZÖSISCHEN SPRACH/ BEGREIFFEND WAS ANFÄNGLICH/ DIESE SPRACH ZUERLERNEN/ AM ALLERNÖHTIGSTEN SEY: DER JUGEND TEUTSCHER NATION: ZU BESTEN VERFERTIGET
Anleitung Zu der Frantzösischen Sprach/ Begreiffend was anfänglich/ diese Sprach zuerlernen/ am allernöhtigsten sey: Der Jugend Teutscher Nation: zu besten verfertiget
Anleitung Zu der Frantzösischen Sprach/ Begreiffend was anfänglich/ diese Sprach zuerlernen/ am allernöhtigsten sey: Der Jugend Teutscher Nation: zu besten verfertiget (Theil 2) ([1]r)
Anleitung Zu der Frantzösischen Sprach/ Begreiffend was anfänglich/ diese Sprach zuerlernen/ am allernöhtigsten sey: Der Jugend Teutscher Nation: zu besten verfertiget (Forts.) ([1]r
An examination of author characteristics in national and regional criminology and criminal justice journals, 2008-2010: Are female scholars changing the nature of publishing in criminology and criminal justice?
No full textCriminology and criminal justice (CCJ) as an academic discipline has experienced an increase in the focus on various aspects of academic productivity in recent years. Much of the extant literature examining journal article authorship has focused on various measures of the publication productivity of specific authors but not on the characteristics of the authors themselves. The current study expands upon previous work by examining several author characteristics across different journal types and research methodologies, with a particular focus on how gender relates to these issues. The findings reveal several interesting differences with regard to gender, academic rank, and university affiliation. Among these findings is evidence that although males are more likely to author CCJ articles regardless of journal type, females are more likely to be lead authors in regional journal articles and more likely to publish with other female authors. Regional journals are also the publication outlet of choice for students and assistant professors in the beginning of their careers. The findings also provide evidence of important differences in author rank, academic affiliation, methodology, and publication outlet for articles authored by females.Journal ArticlePublishe
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