1,721,283 research outputs found
Class effect for SGLT-2 inhibitors: A tale of 9 drugs
No full textThe definition of class effect for SGLT-2 inhibitors may be based on three concepts: a similar chemical structure, a similar mechanism of action and similar pharmacological effects. We have also assumed that a class effect does exist when an effect on a particular outcome is present and is significant for each drug within the class of SGLT-2 inhibitors. For major cardiovascular events (MACE), there is no class effect for SGLT-2 inhibitors, as the 7% reduction of MACE risk observed with dapagliflozin in the DECLARE trial was not significant; on the other hand, a class effect is evident for both heart failure and diabetic kidney disease, as in all four trials so far completed (EMPAREG-OUTCOME, CANVAS, DECLARE, CREDENCE) the risk of hospitalization for heart failure and progression of diabetic kidney disease was significantly reduced by all SGLT-2 inhibitors
Ruolo dei fattori di rischio cardiovascolari nella prognosi dei pazienti diabetici di tipo 2 con nefropatia diabetica.
No full text
Effetti sulla funzionalità cardiaca della terapia con interferone pegilato in pazienti con epatopatia HCV-correlata.
No full text
La risonanza magnetica nella cardiomiopatia ipertrofica: applicazioni emergenti ed esperienza personale.
No full text
- …
