17,047 research outputs found
Feudalita', nobilta' cittadina e reti di credito
No full textUna rilettura del processo che ha portato a un cambiamento negli equilibri tra i gruppi di potere che controllavano non solo il governo delle città siciliane, ma anche gli uffici chiave dell'amministrazione centrale del Regno di Sicilia. La finanza assume un ruolo essenziale in questo processo di trasformazione politica e sociale
Going to the Zoo: A comparison of travel time ratios in 21 European cities
No full textEfficient public transport is an essential component of a sustainable transport system. The travel time ratio, i.e. the public transport journey duration divided by the car journey duration of the same trip, can be used to compare the public transport system with the road transport system within and across cities. However, few studies have used the travel time ratio to analyse the efficiency of the public transport system across European cities. The aim of this study was to compare travel time ratios of a typical leisure trip across 21 European capital cities and to examine the association of journey time and travel time ratio with socio-demographic characteristics of cities. For the purpose of this study trips to the local zoo were selected as a leisure time activity that is comparable across cities in Europe. Within 21 European capital cities random start points were selected based on an 8 km service facilities analysis from the zoo. For each start point to zoo trip the duration and distance of the public transport and car journeys was calculated using the Google Maps Directions API. Our analysis showed that in all cities public transport journeys take longer than car journeys, with a mean travel time ratio of 2.61 (range 0.98–5.82). No correlation was found between public transport and car journey duration, suggesting that they are influenced by different factors. However, mixed model analyses found no association between socio-demographic characteristics of the cities and public transport journey times. In contrast, mixed models showed that a decrease in the travel time ratio was associated with a larger population size, higher population density, higher percentage of working population, more urbanized land area and more registered cars. To encourage a modal shift towards sustainable urban transport, we recommend that travel time ratio should be considered in the design of public transport and car infrastructure in cities
An Article About Albertus C. Van Raalte, Author Unknown, Except for Parts Taken from an Article by Anna C. Post
No full textAn article about Albertus C. Van Raalte, author unknown, except for parts taken from an article by Anna C. Post. The author knew first generation persons in the Holland settlement and therefore, the article has some value.https://digitalcommons.hope.edu/vrp_1890s/1012/thumbnail.jp
The kinesin Eg5 inhibitor K858 induces apoptosis and reverses the malignant invasive phenotype in human glioblastoma cells
No full textGlioblastoma multiforme (GBM) is the most common primary malignant brain tumor and the current chemotherapeutic options for GBM are limited to temozolomide. Recently, inhibitors of kinesin spindle protein Eg5 have shown pronounced antitumor activity and our group has demonstrated that one of these inhibitors of kinesin Eg5, named K858, exerts important anti-proliferative and apoptotic effects on breast cancer cells. Since GBM cells usually express high levels of kinesin Eg5, we tested the effect of K858 on two human GBM cell lines (U-251 and U-87) and found that K858 could inhibit cell growth, induce apoptosis, revert epithelial-mesenchymal transition and inhibit migration in both cell lines. However, at the same time, K858 increased survivin expression, an anti-apoptotic molecule; so, down-regulating survivin with the specific inhibitor YM155, we obtained an important increase of K858-dependent apoptosis. This indicated that the anti-tumor activity of K858 on GBM was limited by the over-expression of survivin and that the negative regulation of this protein could sensitize tumor cells to K858-induced apoptosis. These data support the choice of kinesin Eg5 as target of new therapeutic approaches for GBM; in particular, K858 has been demonstrated to be a potent inhibitor of replication, inducer of apoptosis and negative regulator of the invasive phenotype for GBM cells
On the equity of the x-minute city from the perspective of walkability
No full textWalkability and equity in transport are crucial aspects of sustainable mobility and social well-being. The x-minute city concept emphasizes the importance of walkability, by fostering the design of a city where people can easily access their daily needs aiming to reduce reliance on private cars. However, such approaches, which generally rely on the idea of an “average resident” can ignore inequalities amongst people and fail to achieve the goal of building urban environments where everyone can participate in city life regardless of their socio-economic characteristics and vulnerability. In this study we propose an approach to assess the equity of the x-minute city, highlighting the limitations of the current application of the concept. The approach includes the computation of x-minute thresholds based on the walkability of pedestrian paths and considering different users’ needs. Home to school trips and social trips are taken as a reference; equity metrics such as the Lorenz Curve and Gini Index are used to assess how the x-minute city concurs with the transport equity of a city. The results of the assessment can help identify potential disparities in access to key destinations among different user groups, and support evidence-based policy recommendations to promote equitable transportation options. The case study of Bari, Italy, is used to illustrate the application of the method; however, the proposed approach can be replicated in different contexts, contributing to the ongoing discourse on walkability and equity in transport
Feasibility of a simplified index to improve active mobility infrastructure based on digital survey: the case of Dublin
No full textThe advantages associated with active mobility, i.e. walking and cycling, include not only the possibility of moving in an environmentally friendly way, but also health and economic benefits. Abessing the quality of infrastructures for active mobility should consider aspects related to geometric features, traffic volume and human perception; this can be a time and resources consuming procedure for administrations to be performed on the entire urban area, mostly due to the need to carry out on-site surveys. Based on this premise, the aim of this study is to abess the feasibility of a simplified index for the evaluation of the quality of pedestrian/cycling infrastructure fed by digital survey procedures. The results can be used to provide a first ranking of the roads under study, in order to identify the main criticalities to be analysed through on-site auditing
Richardson, Barbauld, and the construction of an early modern fan club
No full textMPhilMuch has been written about the life and long works of the eighteenth century epistolary novelist, Samuel Richardson, but the prospect of his position as the first celebrity novelist – responsible for courting his own fame as well as initiating his own fan club – has largely been ignored. The body of manuscripts housed at the National Art Library in the Victoria and Albert Museum in London provides the modern scholar with evidence of the skeletal beginnings of an early fan club. This thesis aims to show how these manuscripts were turned into a saleable commodity by the publisher and entrepreneur Richard Phillips, while under the guiding hand of another, slightly later, literary celebrity, Anna Laetitia Barbauld. In order to restore Richardson’s reputation amongst a new nineteenth century audience, Barbauld was required to construct her own idea of him as an eighteenth century celebrity author, and in doing so the insecurities of a self-professed, apparently diffident man, are revealed. Barbauld’s capacious, but heavily edited selection of letters is analyzed in this thesis, providing ample evidence that Richardson’s correspondents were more than just eager letter writers. By using Barbauld’s biography of Richardson this thesis aims to show how she manipulates the genre of life writing in her construction of him.
This thesis offers an alternative reading of how the Richardson manuscripts are viewed, redefining them as not simply a collection of letters, but as a collective entity, deliberately selected and archived as evidence of an early modern fan club, and its celebrity managing director
Selection of work by Anna Gerber
No full textVarious journals and magazines Anna Gerber has contributed to. Anna Gerber is a graphic designer and writer based in London.
She is the author and designer of All Messed Up: Unpredictable Graphics (Laurence King, 2004) and co-editor and co-designer
of Influences: A Lexicon of Contemporary Graphic Design (Die Gestalten Verlag, 2006) with Anja Lutz. She writes regularily for magazines such as Print, Eye, Creative Review, Varoom and Idea Magazine and her work has also been published in shift!, dot dot dot and +rosebud.
She teaches at the London College of Communication on the BA Graphic Design and MA Design Writing Criticism programmes. She has also held workshops and lectures across the U.K. (including Tate Modern and the V&A Museum), as well as in India, the U.S., Australia and Malaysia.
Anna Gerber is currently engaged in research and developing projects relating to sustainability and how it applies to graphic
design as well as exploring contemporary graphic design in India
- …
