682 research outputs found
A Goal-based Framework for Contextual Requirements Modeling and Analysis
No full textRequirements Engineering (RE) research often ignores, or presumes a uniform nature of the context in which the system operates. This assumption is no longer valid in emerging computing paradigms, such as ambient, pervasive and ubiquitous computing, where it is essential to monitor and adapt to an inherently varying context. Besides influencing the software, context may influence stakeholders' goals and their choices to meet them. In this paper, we propose a goal-oriented RE modeling and reasoning framework for systems operating in varying contexts. We introduce contextual goal models to relate goals and contexts; context analysis to refine contexts and identify ways to verify them; reasoning techniques to derive requirements reflecting the context and users priorities at runtime; and finally, design time reasoning techniques to derive requirements for a system to be developed at minimum cost and valid in all considered contexts. We illustrate and evaluate our approach through a case study about a museum-guide mobile information system
“but I am also influenced by no such thing”-The Radical Pietist and Theological Author Johanna Eleonora Petersen
No full textJohanna Eleonora von und zu Merlau, verheiratete Petersen, von jeher tief gläubig, veränderte die religiöse Welt des 17. Jahrhunderts. Sie bekannte sich zur Bewegung des Pietismus und vertrat radikale Ansichten, nicht nur im privaten Kreis, sondern als anerkannte und heftig kritisierte theologische Autorin. Ihrem Werk ist eine Studie gewidmet, in der neue Forschungsergebnisse vorgestellt und Leben und Werk dieser bedeutenden Autorin in zeitgenössische Diskurse eingebunden werden.The deeply devout Johanna Eleonora Petersen, whose maiden name was „von und zu Merlau,” changed the religious world of the seventeenth century. She avowed herself to Pietism and held radical views, not only in private but also as an acknowledged and sharply criticized theological author. This study attends to her work. It presents new research results and weaves the life and work of this important author into contemporary discourses
La notion de défectuosité du produit dans les jurisprudences des pays européens
No full textThis work analyses the notion of defective product originally developed by US Courts, then ambiguously defined by the European directive n. 374 of 1985 and differently interpreted and applied by the respective domestic Courts. In particular, some European jurisdictions apply the risk / utility test introduced by the US Courts for design defects cases, although this test is not mentioned by the European Directive. The author, having highlighted the inconsistences of the risk / utility test, proposes an alternative model of classification of defective products according to the elements actually used by judges in order to allocate the liability, as emerging from the text of their decisions. This classification leads to held the manufacturer strictly liable not only for manufacturing defects, but also for those design defects which he was aware of (as in some cases of defective vaccine).Cette étude examine la notion de défectuosité du produit initialement élaborée par les Cours américaines, définie de manière ambigüe par le législateur européen avec la directive n° 374 de 1985, puis différemment interprétée et appliquée par les Cours respectives des pays membres. Notamment certains systèmes juridiques européens appliquent le risk/ utility test élaboré par les Cours américaines pour les cas de défaut de conception du produit, bien que ce test ne soit pas mentionné par la directive européenne. L’auteur, après avoir mis en évidence les incongruences du risk/ utility test, propose un modèle alternatif de classification des cas de produits défectueux sur la base des critères d’imputation de la responsabilité qui sont concrètement utilisés par les juges et tels qu’imagés dans les textes de leurs décisions. Cette reconstruction amène à imputer au fabricant une responsabilité objective non seulement pour les cas de défaut de production, mais aussi pour les cas de défaut de conception dont il était averti (tel que certain cas de vaccin défectueux).Rajneri Karageorgevitch Eleonora. La notion de défectuosité du produit dans les jurisprudences des pays européens. In: Revue internationale de droit comparé. Vol. 67 N°1,2015. pp. 185-205
TO THE JUBILEE OF PROFESSOR STEPANOVA ELEONORA FEDOROVNA
No full textThe article is devoted to the anniversary of Professor Eleonora Fedorovna Stepanova – a bright representative of the Russian intelligentsia: a talented lecturer, an inventor, an author of numerous books, an internationally recognized scholar
IL BYPASS GASTRICO SU VBG COME TRATTAMENTO DEL FALLIMENTO DELLA GASTROPLASTICA VERTICALE.
No full textRiportiamo i risultati e la tecnica ottenuti trattando le complicanze di interventi restrittivi con una nuova variante tecnica del Bypass Gastrico su ansa alla Rou
Il Bypass Gastrico: evoluzione di una tecnica
No full textRiportiamo l'evoluzione della nostra esperienza in chirurgia bariatrica con l'evoluzione da tecniche tradizionali di Bypass Gastrico su ansa alla Roux a nuove soluzioni per consentire lo studio endoscopico e radiologico dello stomaco esclus
GASTROPLASTICA VERTICALE: 973 CASI CON TECNICA OPEN
No full textRiportiamo i risultati e la tecnica operatoria della Gastroplastica Verticale secondo Mason con le soluzioni tecniche da noi introdotte e i risultati in termini di decremento ponderale e di complicanz
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No full textHebb's idea of a cell assembly as the fundamental unit of neural information processing has dominated neuroscience like no other theoretical concept within the past 60 years. A range of different physiological phenomena, from precisely synchronized spiking to broadly simultaneous rate increases, has been subsumed under this term. Yet progress in this area is hampered by the lack of statistical tools that would enable to extract assemblies with arbitrary constellations of time lags, and at multiple temporal scales, partly due to the severe computational burden. Here we present such a unifying methodological and conceptual framework which detects assembly structure at many different time scales, levels of precision, and with arbitrary internal organization. Applying this methodology to multiple single unit recordings from various cortical areas, we find that there is no universal cortical coding scheme, but that assembly structure and precision significantly depends on the brain area recorded and ongoing task demands
Rescate y conservación del Acervo Histórico del Palacio de Minería: Informe de las labores de conservación preventiva e intervenciones menores en material Bibliohemerográfico y actividades en apoyo al Acervo Histórico : octubre 2011 - febrero 2012
No full textEl presente informe tiene como finalidad dar constancia de los trabajos realizados en el Acervo Histórico del Palacio de Minería, por los restauradores Roderick Palacios, Isabel Ritter y Eleonora Cruz, pasantes de la Licenciatura en Restauración de Bienes Culturales como prestación de su servicio social.</p
Saponins Effect on Human Insulin Amyloid Aggregation
No full textThe misfolding and amyloid aggregation of proteins have been attracting scientific interest for a few decades, due to their link with several diseases, particularly neurodegenerative diseases. Proteins can assemble and result in insoluble aggregates that, together with intermediate oligomeric species, modify the extracellular environment. Many efforts have been and are devoted to the search for cosolvents and cosolutes able to interfere with amyloid aggregation. In this work, we intensively study the effect of saponins, bioactive compounds, on human insulin aggregation. To monitor the kinetic of amyloid aggregation following secondary structure changes, we perform fluorescence and UV-Visible absorption spectroscopies, using Thioflavin T and Congo Red as amyloid specific probes, and Circular Dichroism. To study the overall structural features and size of aggregates, we perform Synchrotron Small-Angle X-ray Scattering and Dynamic Light Scattering experiments. The morphology of the aggregates was assessed by Atomic Force Microscopy. To deepen the understanding of the saponins interaction with insulin, a Molecular Dynamics investigation is performed, too. The reported data demonstrate that saponins interfere with the amyloid aggregation by inducing a strong inhibition on the formation of insulin fibrils, likely through specific interactions with insulin monomers. A dose-dependent effect is evident, and amyloid inhibition is already clear when saponins are just 0.01% w/w in solution. We suggest that saponins, which are natural metabolites present in a wide range of foods ranging from grains, pulses, and green leaves to sea stars and cucumbers, can be promising metabolites to inhibit human insulin aggregation. This basic research work can pave the way to further investigations concerning insulin amyloidosis, suggesting the use of saponins as amyloid inhibitors and/or stabilizing agents in solution
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