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Cross-tolerance and convergent dependence between morphine and cannabimimetic agent WIN 55,212-2 in the guinea-pig ileum myenteric plexus
No full textSerum corticosterone as a quantitative test of the phlogistic potency of various agents topically applied in the rat..Arch Int Pharmacodyn Ther. 1976 Dec;224(2):263-74.
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Cerebral sites of central action of dermorphin on intestinal motility in the rat.Peptides. 1985;6 Suppl 3:149-53
No full textInfluence of ω-conotoxin on morphine analgesia and withdrawal syndrome in rats
No full textThe effect of ω-conotoxin on opiate analgesia and withdrawal syndrome was investigated in rats. ω-Conotoxin given i.c.v. and i.p. caused weak analgesia in the tail-flick test. When the toxin (20 ng/rat) was given i.c.v. immediately before morphine (1.5 μg/rat i.c.v.) the resultant analgesic effect was additive. In contrast, the analgesia elicited by morphine (3 μg/rat i.c.v.) was greatly reduced after 24-h pretreatment with the toxin (20 ng/rat i.c.v.). The systemic administration of the toxin (10 μg/kg i.p.) did not affect morphine analgesia whether ω-conotoxin was coadministered with morphine (2.5 mg/kg i.p.) or was given 24 h before the opiate (5 mg/kg i.p.). ω-Conotoxin i.c.v. injected in morphine-dependent rats 15 min before naloxone challenge significantly attenuated the abstinence syndrome. On the contrary systemic administration of ω-conotoxin failed to suppress the morphine withdrawal syndrome. The present results suggest that ω-conotoxin affects both acute and chronic effects of morphine. © 1992
Liver tyrosine-alpha-ketoglutarate transaminase as a quantitative test of the phlogistic potency of agents topically applied... 1976 Oct;8(5):463-8
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