1,721,073 research outputs found
CARDIAC STEM CELLS: ISOLATION, EXPANSION AND EXPERIMENTAL USE FOR MYOCARDIAL REGENERATION
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Adenine-induced hypoxanthine release from IMP-enriched human erythrocytes.
No full textAdenine uptake and hypoxanthine release by IMP-enriched human erythrocytes has been studied. The presence of IMP within the erythrocytes leads to an increase in the rate of adenine incorporation. Adenine is taken up by IMP-enriched erythrocytes as AMP, even when intracellular 5-phosphoribosyl-1-pyrophosphate concentration is undetectable and too low to allow IMP synthesis from hypoxanthine. During adenine uptake and AMP synthesis, hypoxanthine is released by the cells. The possibility that 5-phosphoribosyl-1-pyrophosphate, necessary for AMP synthesis, is formed through the hypoxanthine guanine phosphoribosyltransferase-catalyzed IMP pyrophosphorolysis is considered
Diabetic cardiomyopathy: a “cardiac stem cell disease” involving p66Shc, an attractive novel molecular target for heart failure therapy
No full textHuman hypoxanthine-guanine phosphoribosyltransferase. Steady state kinetics of the forward and reverse reactions
No full textA steady state kinetic study of the hypoxanthine-guanine phosphoribosyltransferase-catalyzed reaction in the forward and the reverse directions was carried out. The results obtained favor a sequential mechanism where the monomagnesium complexes of IMP and PP(i) bind to the enzyme in a rapid equilibrium random fashion while products must dissociate from the enzyme in ordered sequence, first the purine base and then the magnesium complex(es) of P-Rib-PP
Hypoxanthine-guanine phosphoribosyltransferase has a major role in the uptake of hypoxanthine and guanine by mammalian cells
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A continuous Spectrophotometric assay for hypoxanthine-guanine phosphoribosyltransferase.
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