1,721,075 research outputs found
The psychiatrists of the new millennium: training needs, clinical skills and professional risks
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Una strategia di trattamento combinato con cloripramina ed aripiprazolo nella depressione resistente
No full textRisposta al trattamento con inibitori del reuptake della serotonina nel disturbo ossessivo-compulsivo ad esordio precoce
No full textPathways to care, duration of untreated psychosis and duration of untreated illness in Italy: a retrospective survey
No full textPercorsi di cura, durata di psicosi non trattata e durata di malattia non trattata in Italia: un'indagine retrospettiva
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Obsessive-compulsive disorder with comorbid schizotypal personality disorder: A novel clinical form?
No full textDifferent studies have identified specific clinical characteristics of patients with obsessive-compulsive disorder (OCD) in comorbidity with schizotypal personality disorder (SPD), although no perspective evaluations of prognosis and response to treatment have been conducted so far. The aims of the present study were to evaluate: (1) the clinical and demographic correlates of OCD patients with comorbid SPD (OCD-SPD) using standardized instruments; (2) the response of OCD-SPD patients to long-term naturalistic pharmacological treatment. Socio-demographic and clinical characteristics of patients with OCD-SPD were compared to patients with “pure OCD”. OCD-SPD patients were characterized by a greater severity of obsessive-compulsive symptomatology, earlier age at onset, a higher rate of schizophrenia spectrum disorders in their first-degree relatives and a poorer insight. During the observational period, OCD-SPD patients were less likely to achieve remission of their symptomatology and required a greater number of trials with different antipsychotic drugs or received more frequently augmentation with antipsychotics. Our findings suggested that comorbidity with SPD is correlated to a poor treatment response in OCD patients and a reduced likelihood to recover from OCD symptoms, following standard pharmacological treatments. Further research is needed to identify alternative strategies for the management of this cohort of patients
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