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Neuropeptide Y inhibits forskolin-stimulated adenylate cyclase activity in rat hippocampus. Petrenko S, Olianas MC, Onali P, Gessa GL.
No full textNeuropeptide Y inhibited the forskolin-stimulated adenylate cyclase activity in rat hippocampus with the half-maximal effect occurring at 73 nM. The maximal inhibition corresponded to a 17-22% decrease of the control level of enzyme activity. The effect of neuropeptide Y was mimicked by the peptide YY but not by the avian pancreatic polypeptide and required micromolar concentrations of GTP. These results indicate that, in the brain, the inhibition of adenylate cyclase activity constitutes a mechanism by which the receptor for neuropeptide Y transduces its signal
Alcohol: an overview
No full textIl consumo di alcol rappresenta uno dei principali fattori di rischio pe la salute. La diagnosi precoce del consumo eccessivo di alcol permette l'attuazione dell'intervento breve, un intervento efficace nel prevenire la comparsa di dipendenza da alcol
A simple radioenzymatic method to measure picogram amounts of DOPA in brain and biological fluids
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