1,720,975 research outputs found
Le malattie cutanee.
No full textRiassunto. Viene discussa la fisiologia della risposta cutanea a Noxae esogene e i meccanismi di difesa della cute. Le dermopatie professionali sono state classificate come Dermatiiti Allergiche da contatto, Dermatiti da contatto irriitante, Dermatiti tossiche , Dermatiti da infezione o infestazione da agenti biologici e Neoplasie cutanee. Per ciascuna categoria viene discusso il quadro clinico, l'etiopatogenesi, i protocolli diagnostici e diagnostico-differenziali. Infine vengono trattati gli aspetti preventivi, con particolare riguardo ai Dispositivi Individuali di Prevenzione e alle misure legate alla protezione della cute con adeguati detergenti e idratanti
Natural latex allergy. Patient management: from clinic to prevention. A review Allergia a latice naturale. Gestione del paziente: dalla clinica alla prevenzione. Rassegna critica
No full textAbstract
The widespread use of latex devices has been followed, in the last 25 years, by an increase in IgE mediated sensitization. The clinical manifestations of latex allergy affect the skin (urticaria and angioneurotic oedema), the lower and the upper respiratory tracts (rhinoconjunctivitis, asthma and glottis oedema), and the cardiovascular system (anaphylaxis). There is also an anaphylactic risk during surgery and invasive diagnostic procedures. Vegetable food cross-reacts with latex so that more than half of the patients show specific IgE against some food. Further than traditional groups at risk, as health care workers, other work categories have to be protected, because of the inappropriate use of latex gloves (food or drug industry workers, mechanics, panel beaters and so on). Recently the latex most important allergenic fractions have been characterized and recombinant allergens are now available. The recombinant allergens allow a better standardization of the extracts for diagnostic use, the production of safer extracts for immunotherapy as well as a more accurate evaluation of food cross-reactions. The recombinant allergens will allow a more accurate dosage of latex concentrations in air and in objects and, in future, to establish threshold limit values. The main aims of prevention are the replacement of latex with alternative elastomers, the reduction of work and extra work exposure and an efficient health survey in working environment. The use of latex gloves and devices among general population has to be discouraged. Specific immunotherapy has to be considered a second choice and restricted to highly qualified workers in order to realize a rehabilitation to their previous jobs. The actually obtained protection must be verified
Latex allergy: natural story
No full textAbstract. La sensibilizzazione IgE mediata a proteine presenti nei manufatti in latice naturale è responsabile non solo di manifestazioni cutanee come prurito od orticaria localizzata, spesso accompagnata da edema angioneurotico, ma anche di sintomi respiratori a carico delle alte come delle basse vie respiratorie, con quadri di oculorinite, di asma bronchiale e, talora, di edema della glottide. Si possono verificare inoltre manifestazioni cardiovascolari fino allo shock anafilattico. I sintomi compaiono in seguito a contatto ed assorbimento percutaneo, ma anche per via inalatoria. Gli antigeni presenti nei manufatti in latice possono infatti essere veicolati in aria dalla polvere lubrificante dei guanti per uso sanitario o di altri manufatti. Storia naturale. Le prime manifestazioni cliniche sono nella grande maggioranza a livello cutaneo, che in circa un terzo dei casi si complicano successivamente con interessamento delle vie respiratorie (Asma o rinite). In una piccola percentuale di soggetti, i sintomi possono tuttavia esordire a livello respiratorio, senza interessamento cutaneo. Dopo la cessazione dell'esposizione la sintomatologia cutanea regredisce prontamente, mentre i sintomi respiratori o l'iperesponsività alla metacolina possono persistere in oltre il 40% dei lavoratori affetti. Importanti fattori predisponenti la sensibilizzazione sono l'atopia e la preesistenza di patologie cutanee come la dermatite atopica, l'eczema da contatto e in genere tutte le situazioni che comportano soluzioni di continuo della cute. Frequente la sensibilizzazione crociata con alimenti vegetali, che può causare la cosiddetta "Latex-fruits Syndrome"
Eczema allergico da contatto (DAC) nel personale sanitario. Quali apteni sono maggiormente responsabili della sensibilizzazione?
No full textABSTRACT
In the last decades, the enhanced use of rubber gloves caused an increase of allergic dermatitis among health workers. The aim of our study was of finding out the most common sensitizing agents causing the diseases. We found that the accelerators are most often implicated. We recommend a panel of substances to be tested by patch test in skin symptomatic workers, in particular, carbamates, thiurams and metals
Prevalence of contact urticaria in health care workers.
No full textAbstract. Latex allergy is a major cause of IgE-mediated urticaria in occupational dermatology. Urticaria may be complicated by other pathological conditions, affecting the respiratory system: asthma and rhinitis. A cohort of 735 health workers examined at the Allergy Surgery of the Department of Environmental Medicine and Public health has been studied. All people (295 subjects, 40,1%) who experienced symptoms were examined. Latex exposure data were recorded, dividing the cases into three risk categories, high, medium and low, together with allergic symptoms and previous story of allergic diseases. In the group of 295 symptomatic patients, 130 workers (44.0%) reported symptoms of urticaria associated with occupational exposure. About half (46.1%) of these subjects were sensitized to natural latex. No correlation between risk exposure category and the latency to onset of symptoms was found, the prevalence of latex sensitization was similar in all groups. The likelihood of developing latex sensitization or allergy correlated only with the variable atopy
Orticaria ed angioedema da sensibilizzazione a caseina in ambiente di conceria: case report
No full textABSTRACT
In the last decades, the enhanced use of rubber gloves caused an increase of allergic dermatitis among health workers. The aim of our study was of finding out the most common sensitizing agents causing the diseases. We found that the accelerators are most often implicated. We recommend a panel of substances to be tested by patch test in skin symptomatic workers, in particular, carbamates, thiurams and metals
Environmental effects on immune system and allergy.
No full textIncidence and severity of allergic diseases of the upper and lower airwys has been increasing throughout this century. The hallmark of these disorders is increased IgE production. Many epoidemiological studies have provided indirect evidence for an increased incidence of asthma and atopy linked to airborne pollution in developed countries. In order to better understand the complex interaction(s) between pollution and allergic diseases, we suggest to consider four fundamentl mechanisms. 1. Increased concentration of airborne allergens in urban areas and workplaces. 2) Adjuvant effect. 3) Xenobiotic interaction(s) with immune system. 4) Effects of pollutants on target organs. In conclusion, although epidemiological and laboratory studies show contrasting results, there is evidence that xenobiotics are involved in the pathogenesis of allergic diseases through specific and non-specific mechanisms
Latex allergy
No full textNatural rubber latex (NRL) is a product derived from the cytosol of the commercial rubber tree, Heve brasiliensi. The essential functional unit in latex is a rubber particle, a spherical droplet of cis-1,4-polyisoprene that is coated by a layer of protein, lipid and phospholipid. Durin processing and production more than 200 different chemicals are added in order to improve product properties. About 90% of harvested rubber is processed by acid coagulation and the formed rubber products contain few latex proteins. The remaining 10% of harvested rubber is non coagulated and ammoniated, and it is used in manufacturing "dipped" rubber products such as gloves, condoms, and balloons. Currently, more than 40,000 articles on the market ar NRL made. Sice the beginning of the eighties there has been an increased number of reports about IgE-mediated allergy. Clinical symptoms of latex allergy range from urticaria, conjunctivitis and rhinitis to asthma and anaphylactic shock. Health care workers (HCW) children with spina bifida (SB), workers in industries that manifacture latex , are known to be the highest risk populations. A better knowledge of allergenic proteins and the productions of purified NRL allergens will be useful o develop more specific extracts for skin test and in vitro studies, improving diagnostic procedures. Measurement of natural rubber latex allergens in medical gloves and airborne disoered latex allergens in the workplace would be helpful for preventive purposes
Allergeni indoor: non solo acari.
No full textSummary: The indoor environment is a source of airway risk factors. The main agents related to exacerbation and development of rhinoconjunctivitis and asthma are house dust mites, pet’s epithelia, moulds, environmental tobacco smoke, and outdoor and indoor chemical pollutants. This paper reports the relationship between the outdoor and indoor concentrations of pollen and mould spores
Airborne pollen in Padua (NE-Italy): A comparison between two pollen samplers
No full textAbstract
During recent years a gradual decrease in allergenic airborne pollen concentration has been observed in the
monitoring station of Padua (Italy). Because technical checks of the sampler were not able to explain this trend, the
results obtained from two twin pollen-samplers (Lanzoni VPPS 2000), placed two metres apart, were compared. An
eight-week sampling was carried out during the year 2000 from July to September. Subsequent analysis revealed
no statistically significant difference between the data obtained with the two instruments. On the other hand, both
samplers captured high levels of fungal spores.We conclude that the observed negative trend in pollen count is real
and not related to technical biases
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