1,721,026 research outputs found
La scintigrafia salivare sequenziale nella sindrome di Sjögren: utilità di un nuovo parametro di lettura
No full textSequential salivary scintigraphy in Sjögren's syndrome: proposal for a new method of evaluation.
No full textThirty-seven non-elderly primary Sjögren's syndrome (I SS) patients, and 27 controls complaining of xerostomia and/or recurrent or persistent swelling of at least one parotid or submandibular gland due to other selected disorders, were studied. A new scintigraphic score (scsc) is proposed for a standardised semiquantitative evaluation of salivary involvement by qualitative sequential salivary scintigraphy (SSS), and is compared with two other well-known methods generally used for this purpose. The scsc proved to be much more suitable for such an evaluation: the other criteria did not allow us either to classify or to score a great number of cases. Furthermore, the scsc allowed us to obtain better SSS sensitivity (89.2%) and specificity (96.3%) values for I.SS (33 of the 37 I SS patients and 26 of the 27 controls were correctly classified by discriminant analysis, for scsc values greater than 8). This was made possible by the different "weights" which we assigned to the various glandular and oral parameters in the scsc determination
Danno glomerulare progressivo in cancerosi trattati con dd-platino (DDP); ulteriori osservazioni.
No full text
Bone Scan for Baseline Staging in Invasive Breast Cancer at the Time of Primary Presentation
No full textTechnetium-labeled methylene diphosphonate bone scan (BS) is the most commonly used imaging test to screen for skeletal metastases in patients with breast cancer. Since its introduction into clinical practice, a large number of studies have been conducted to explore the role of BS in the baseline staging work-up at the time of breast cancer diagnosis. Even though the policy of offering preoperative or perioperative BS is still widely diffuse, a lot of evidence in the literature suggests that routine BS examinations are not cost-effective and should be recommended in selected cases only. Based on current guidelines, the use of BS as a staging procedure is considered appropriate in patients with a high pre-test probability (prevalence) of bone metastases. This category is represented by patients with newly diagnosed high-risk breast cancer (i.e. pN2 or T4/pT4) or with symptoms or laboratory signs suspicious for bone involvemen
RELATIVE 201-TI AND TC-99M-MIBI UPTAKE IN PARATHYROID ADENOMAS - THE EFFECT OF CELLULAR TYPE AND SERUM PTH CONCENTRATION
No full textMOLECULAR ANALYSES OF SENTINEL LYMPH NODES: AN OPEN QUESTION
No full textAims To detect micrometastases in the sentinel lymph nodes (SLN) of melanoma patients the authors analysed 52 lymph nodes (47 SLNs and five non-sentinel) and 17 corresponding primary skin melanomas using reverse transcriptase–polymerase chain reaction assays in paraffin-embedded tissues to detect the mRNAs of tyrosinase, MAGE1, MAGE3, MIA, MART-1 and mRNA coding for telomerase catalytic component.
Results Our data show that the use of molecular markers for melanoma micrometastases detection in SLN is still in a very preliminary stage. In comparing the molecular analysis results with the pathological staging we did not find any evident correlation with the expression of the analysed genes in SLN. There are no data for judging the prognostic significance of the detection of circulating tumour cells in patients without clinically recognizable metastases. Despite progress in the field with simultaneous detection of several markers it was assumed that tyrosinase mRNA remains the best target for the detection of metastatic melanoma cells
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