779 research outputs found
Lidia Shank
No full textPhotograph - Portrait of Lidia Shank, a member of the Canadian Women's Army Corps, in uniform. Athabasca, Albert
Ed and Lidia Loxam
No full textPhotograph - Ed Loxam and Lidia Loxam (nee Shank) inside a cabin, Athabasca, Albert
A Field Survey on Promotion of Safety in School Laboratories
No full textA training activity was conducted in a technical high school aimed at promoting
the health and safety culture in chemistry laboratories. 84 students were
involved. Three seminar meetings and three laboratory workshops were held. At
the beginning of the activity (T0) and at the end (T1) the following tools were
given to the students: a questionnaire on the topics covered by the training
activity; a questionnaire containing the general risk propensity scale and some
additional questions relating to the perception of risk. A comparison of the data
between T0 and T1 revealed an overall improvement in students’ ability to
identify specific hazards, but it also highlighted the need to improve the good
laboratory practices. Students tend to attribute a greater awareness to themselves
than they are willing to acknowledge in their peers. It emerged a more effective
promotion of risk-awareness rather than risk-management, as predictable,
considering the short intervention tim
Giovanni Casertano, Tra musica e filosofia: le passioni, l’anima e il logos (a cura di Lidia Palumbo),
No full textAbstract Between music and philosophy: passions, soul and logos
The paper presents a comment, in a musical key, of Encomium of Elena. Gorgias famous play, produced in the fifth century BC, is about passions, soul and speeches. The author then considers the influence of this text of Gorgias on the dialogues of Plato, in relation to the great themes of soul and body, human passions, the power of words. The musical register sustains the whole paper to show how philosophy is the megiste musiké of which Socrates speaks in Phd. 61a
Liquid Biopsy in Glioblastoma Management: From Current Research to Future Perspectives.
No full textGlioblastoma (GBM) is the most common primary tumor of the central nervous system. Arising from neuroepithelial glial cells, GBM is characterized by invasive behavior, extensive angiogenesis, and genetic heterogeneity that contributes to poor prognosis and treatment failure. Currently, there are several molecular biomarkers available to aid in diagnosis, prognosis, and predicting treatment outcomes; however, all require the biopsy of tumor tissue. Nevertheless, a tissue sample from a single location has its own limitations, including the risk related to the procedure and the difficulty of obtaining longitudinal samples to monitor treatment response and to fully capture the intratumoral heterogeneity of GBM. To date, there are no biomarkers in blood or cerebrospinal fluid for detection, follow-up, or prognostication of GBM. Liquid biopsy offers an attractive and minimally invasive solution to support different stages of GBM management, assess the molecular biology of the tumor, identify early recurrence and longitudinal genomic evolution, predict both prognosis and potential resistance to chemotherapy or radiotherapy, and allow patient selection for targeted therapies. The aim of this review is to describe the current knowledge regarding the application of liquid biopsy in glioblastoma, highlighting both benefits and obstacles to translation into clinical care. Implications for Practice To translate liquid biopsy into clinical practice, further prospective studies are required with larger cohorts to increase specificity and sensitivity. With the ever-growing interest in RNA nanotechnology, microRNAs may have a therapeutic role in brain tumors
Meningioma: Not always a benign tumor. A review of advances in the treatment of meningiomas
No full textMeningiomas are the most common primary intracranial tumors. The majority of meningiomas are benign, but they can present different grades of dedifferentiation from grade I to grade III (anaplastic/malignant) that are associated with different outcomes. Radiological surveillance is a valid option for low-grade asymptomatic meningiomas. In other cases, the treatment is usually surgical, aimed at achieving a complete resection. The use of adjuvant radiotherapy is the gold standard for grade III, is debated for grade II and is not generally indicated for radically resected grade I meningiomas. The use of systemic treatments is not standardized. Here we report a review of the literature on the clinical, radiological and molecular characteristics of meningiomas, available treatment strategies and ongoing clinical trials
Hypothyroidism in patients with hepatocellular carcinoma receiving cabozantinib: an unassessed issue
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Glioblastoma: Emerging treatments and novel trial designs
No full textSimple Summary Nowadays, very few systemic agents have shown clinical activity in patients with glioblastoma, making the research of novel therapeutic approaches a critical issue. Fortunately, the availability of novel compounds is increasing thanks to better biological knowledge of the disease. In this review we want to investigate more promising ongoing clinical trials in both primary and recurrent GBM. Furthermore, a great interest of the present work is focused on novel trial design strategies. Management of glioblastoma is a clinical challenge since very few systemic treatments have shown clinical efficacy in recurrent disease. Thanks to an increased knowledge of the biological and molecular mechanisms related to disease progression and growth, promising novel treatment strategies are emerging. The expanding availability of innovative compounds requires the design of a new generation of clinical trials, testing experimental compounds in a short time and tailoring the sample cohort based on molecular and clinical behaviors. In this review, we focused our attention on the assessment of promising novel treatment approaches, discussing novel trial design and possible future fields of development in this setting
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