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Laparoscopic sentinel lymph node mapping in endometrial cancer
Full text linkPREFACE OF THE PhD THESIS: The sentinel lymph node mapping represents one of the research lines of the candidate during her PhD activity at the Department of Gynecology and Obstetrics, at the University of Bern, under the supervision of Prof. MD Mueller.
During this period, the candidate authored/coauthored 16 articles in the field of sentinel lymph
node mapping in uterine cancers; part of them were multicentric trials, edited in cooperation with
several other European Academic Institutions.
In this thesis, the candidate focused the main results achieved in this period, in the setting of the
clinical application of lymph node mapping in endometrial cancer
Effect of neoadjuvant chemotherapy on primary treatment interval in patients with advanced ovarian cancer
No full text
Successfull laparotomic miomectomy of a large subserosal myoma causing hydronephrosis at 16th week of pregnancy
No full textEndometrial and cervical cancer patients with multiple sentinel lymph nodes at laparoscopic ICG mapping: How many are enough?
No full textPurpose The adoption of a sentinel lymph node (SLN)
algorithm and the presence of high bilateral detection rates
have been associated with increased accuracy of SLN mapping
in cervical and endometrial cancer patients. In this
context, the significance of the number of SLNs removed
has not yet been investigated. The aim of this study was to
evaluate (a) whether or not a higher SLN removal count
is associated with a reduced false-negative rate and (b)
which clinical factors correlate with the number of SLNs
removed.
Methods Patients with cervical or endometrial cancer who
underwent SLN mapping with bilateral SLN detection followed
by lymphadenectomy were evaluated retrospectively.
On the basis of the mean number of the SLNs removed,
the patients were divided in two groups: Group 1 included
patients with up to 3 SLNs removed and Group 2 included
patients with more than 3 SLNs removed. Factors predicting
a higher SLN count were evaluated using univariate and
multivariate analysis.
Results Eighty-four patients met the inclusion criteria.
The two groups consisted of 42 patients each and differed
only by the median SLN count. Two endometrial cancer
patients in Group 1 had false-negative pelvic SLNs and isolated
para-aortic metastases; no false-negative SLNs were
recorded in Group 2 (p = n.s.). The results of multivariate analysis indicted that the number of SLNs removed was
influenced only in cases where the operating surgeon had
performed more than 20 laparoscopic ICG SLN mappings.
Conclusions A higher SLN count does not seem to increase
the accuracy of SLN mapping in cervical and endometrial
cancer patients
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