1,720,969 research outputs found
Borrelia burgdorferi, a great chameleon: know it to recognize it!
No full textBorrelia burgdorferi is a spirochaete that can penetrate the blood-brain barrier in early infection and can cause endothelial damage other than central nervous system lesions. We describe a clinical case of neuroborreliosis that occurred in the absence of classical erythema migrans or arthralgia. Magnetic resonance imaging findings compatible with simil-vasculitis and demyelinating lesions associated with the presence of anti-B. burgdorferi antibodies in the plasma or cerebrospinal liquid is an indication for antimicrobial treatment against B. burgdorferi. An early diagnosis and a prompt establishment of an adequate antibiotic treatment is needed for a successful recovery
AUTOIMMUNE HEMOLYTIC-ANEMIA ASSOCIATED WITH CANCER
No full textTwelve patients with autoimmune hemolytic anemia (AIHA) associated with carcinoma are presented. Ten were affected with anemia during the course of the neoplastic disease. In two patients, severe autoimmune hemolysis manifested the presence of cancer. Corticosteroid therapy, successfully employed in idiopathic AIHA, was ineffective or showed only an initial partial response. In one case, therapy for carcinoma with chemo-radiotherapy led to the disappearance of antibodies and anemia. In two cases, surgical removal of the tumor caused remission of the AIHA. The possibility of an occult tumor in patients with apparently idiopathic AIHA and the possible autoimmune etiology of anemia in cancer should therefore be considered although the pathogenic mechanisms of autoimmune hemolytic disease in cancer patients has still not been well defined
AUTOIMMUNE THROMBOCYTOPENIC PURPURA ASSOCIATED WITH DIFFERENT FORMS OF CANCER
No full textTwenty-two patients with autoimmune thrombocytopenic purpura (ATP) associated with different forms of neoplasms are presented. Cancer-related ATP appeared at the time of either the clinical manifestation or relapse of the neoplastic disease, sometimes one month to 10 years after surgery and/or radio-or chemotherapy. All the patients presented high levels of both platelet-associated IgG and less frequently of serum-platelet bindable IgG. The surgical removal of the tumor performed in some thrombocytopenic patients did not induce the remission of ATP. The clinical and hematological response to steroid therapy was generally poor. The possibility of an occult tumor in patients with apparently idiopathic ATP and the possible autoimmune etiology of thrombocytopenia in cancer should therefore be considered, although the pathogenetic mechanisms of autoimmune diseases in neoplastic patients have not yet been well defined
ISOLATION AND EX VIVO EXPANSION OF BONE MARROW-DERIVED PORCINE MESENCHYMAL STROMAL CELLS:POTENTIAL FOR APPLICATION IN AN EXPERIMENTAL MODEL OF SOLID ORGAN TRANSPLANTATION IN LARGE ANIMALS
No full textInterphase cytogenetics of bladder cancer progression: relationship between aneusomy, DNA ploidy pattern, histopathology, and clinical outcome
No full textIn the present study, different stages of transitional cell carcinoma of the bladder were analyzed by fluorescent in situ hybridization, using probes specific for pericentromeric classical satellite. Seventy primary tumors were evaluated for chromosomes 1, 7, 9, 17, and ploidy by flow cytometry. The results were correlated, after a mean follow-up period, with ploidy, histopathological characteristics, recurrence, and progression. Firstly, our data demonstrated that the sensitivity of fluorescence in situ hybridization in detecting quantitative DNA. aberrations exceeds that of flow cytometry. The frequency of chromosome I and 9 aberrations was not significantly different in diploid and aneuploid tumors of different stage and grade. In contrast, the chromosome 7 and 17 aneusomy showed greater differences between pT1 and pT2-3 tumors (P<0.032 and P<0.0006, respectively) than between stage pTa and pT1. An increasing number of aberrations was observed in all chromosomes examined from turners of patients that afterwards underwent cystectomy and/or had recurrent tumors. This study indicates that fluorescence in situ hybrization could be used to detect genetic changes relevant to patient outcome. These genetic changes could identify patients at high risk of recurrence and possible progression
Age-related prevalence of platelet-associated Immunoglobulins G in nonthrombocytopenic patients with autoimmune thyroid disease and autoimmune polyglandular syndrome
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