1,720,992 research outputs found
Electrocardiographic alterations as a result of acute intoxication with fluvoxamine and pipamperone
No full textThe cardiologic effects of psychotropic drugs (especially antidepressants and antipsychotics) are well known and debated both when prescribing them to psychiatric patients and when used by patients themselves in suicide attempts. We review the litearture concerning electrocardiographic alterations secondary to the use of psychotropic drugs and describe a case of intoxication (overdose during an attempted suicide) by a patient receiving fluvoxamine and pipamperone
Quadriplegia due to pachymeningitis, vasculitis and sepsis in a patient with rheumatoid arthritis: A case report
No full textWe report the case of a 84-year-old man, with history of rheumatoid arthritis, admitted the Hospital for a fall and complaining of dysaesthesia and pain located to the cervical spine and arms. Within a few hours after admission, fever and acute, progressive, ascendant quadriplegia became evident. Magnetic resonance imaging (MRI) of cervical spine showed spinal canal stenosis between C4-C6 with spinal cord compression. Hemocultures resulted positive for Staphylococcus aureus. The clinical picture rapidly evolved to sepsis with a fatal multi-organ failure. An autopsy found a osteosclerosis narrowing the neurocanal at the level of C3-C6, and recent cervical medulla infarction. A histological exam revealed the presence of a suppurative pachymeningitis with local phenomenas of periradiculitis, vasculitis and thrombosis of the anterior medullar artery, associated with coagulative necrosis of the neural tissue
Reversible hyperthyroidism and cardiomyopathy caused by consumption of iodocasein
No full textWe report the case of a 52-year-old woman with recent diagnosis of acute myocarditis and pericarditis, admitted for fever, tachycardia, and dyspnea upon exertion. Hematochemical parameters and instrumental examinations suggested iatrogenic hyperthyroidism and secondary dilated cardiomyopathy. Although gathering information about the medication used at home was initially difficult because of the patient’s refusal to cooperate, she ended up by disclosing the regular assumption of an iodocasein drug. A complete and stable regression of the clinical picture was reached by suspending the iodine derivative and using cardiovascular drugs
Occipital Headache and septicemia. An unusual case of isolated sphenoid sinusitis
No full textIsolated sphenoid sinusitis is a rare disease with potential devastating complications such as cranial nerve involvement, brain abscess, and meningitis. We report a case of unilateral sphenoid sinusitis presenting as persistent occipital headache and septicemia
Risk of hospitalization for upper gastrointestinal tract bleeding
No full textObjective: This study evaluates the hospitalization risk for upper gastrointestial bleeding (UGIB) with reference to the clinical characteristics of patients and drugs taken before admission. Methods: This study is based on the GIFA (Italian Group for the Pharmacosurveillance in the Elderly) database. Cases with an ICD-9 code of esophagus, stomach or duodenum bleeding, or acute esophago-gastroduodenal disease associated with anemia have been classified as UGIB. Sex, age, year of observation, drugs taken at home, comorbidity, smoking, alcohol, and use of gastroprotectants have been also taken into account. Statistical analysis has been conducted using multivariate logistic regression models. Results: 32,388 patients have been enrolled, 940 of which presented UGIB. Age, comorbidity, use of smoke and alcohol, hospitalization duration, and mortality during hospitalization were significantly higher in UGIB than nonUGIB patients. Increased UGIB risk has been found in patients taking NSAIDs(both when aspirin was included or excluded), acetaminophen, constipating agents, iron, ethacrynic acid, propranolol. Reduced UGIB risk has been found in patients taking nitrates. Conclusions: UGIB risk appears to correlate with clinical characteristics of the patient: it increases with age, comorbidity, and smoke and alcohol consumption. Among drugs, NSAIDs are associated with the highest UGIB risk, while nitrates with a reduction of risk
Variations in serum ion levels in acute myocardial ischemia: Possible insights for diagnosis and therapy
No full textVariations in serum levels of calcium (Ca2+), sodium (Na+, potassium (K+), chloride (CI-), phosphorus (HPO42-, H2PO4-), and magnesium (Mg2+) ions during acute myocardial ischemia were analyzed in 55 patients with acute myocardial infarction (AMI), 60 patients with episodes of angina (EA), and 76 patients with noncardiac chest pain (NCP). Serum levels of Na+, phosphorus ions, and Mg2+ were lower in patients with AMI and EA than in patients with NCP; patients in the AMI and EA groups had lower serum levels of Ca2 and Cl- compared with the NCP group. A significant negative correlation was found between creatine phosphokinase and Na+, phosphorus ion, and Mg2+ levels
Acute myocardial infarction: Circadian, weekly, and seasonal patterns of occurrence
No full textConvincing evidence has demonstrated that cardiovascular diseases do not occur randomly throughout the day, the week, or the year but show a well defined temporal organization. This article will review circadian, weekly, and seasonal patterns of occurrence of acute myocardial infarction, along with their underlying pathophysiological triggering factors
Circadian circannual rhythmicity in the occurence of the subarachnoid hemorrhages
No full textInvestigation of the temporal pattern of SH and differences related to sex, age and risk factors
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