1,720,975 research outputs found
Chemo‐enzymatic derivatization of glycerol‐based oligomers: structural elucidation and potential applications
No full text: Switching from oil-based to bio-based feedstocks to ensure the green transition to a sustainable and circular future is one of the most pressing challenges faced by many industries worldwide. For the cosmetics and personal and house care industries there is a strong drive to accelerate this transition from the customers that starts favoring the purchase of naturally derived and bio-degradable products over the traditionally available products. In this work we developed a series of fully biobased macromolecules constituted of a glycerol-based oligoester backbone. Based on the subsequent derivatization with fatty acids or peptides, the resulting products may find application as emulsifiers, wetting agents, and potential vectors for the delivery of bioactive peptides. All steps of the resulting macromolecules were conducted following the green chemistry principles with no toxic or environmentally damaging compounds that were used in the overall production process
Simple synthesis of P1P2-Diadenosine 5'-pyrophosphate
No full textPyrophosphate-linked coenzymes play essential roles in several biochemical systems. Symmetrical diadenosine-5'-pyrophosphate (Ap2A) has been synthesized from adenosine-5'-phosphate in virtually quantitative yield. The simple procedure is carried out in anhydrous pyridine using adenosine phosphoromorpholidate and adenosine monophosphate bis-(tri-n-butylammonium salt) as coupling reagents
A study on a primitive artificial esterase model. Reactivity of a calix[4]resorcinarene bearing carboxyl groups
No full textConjugation of Hydroxytyrosol with Other Natural Phenolic Fragments: From Waste to Antioxidants and Antitumour Compounds
No full textHydroxytyrosol, a natural polyphenol that can be extracted from olive mill waste waters, was converted into a series of more complex and lipophilic analogues by conjugation with other naturally derived (poly)phenolic fragments. Ether and triazole linkers were employed. A small library of compounds was prepared, stressing step economy and operational simplicity. Some of these substances were proven to have activity equal or superior to that of the parent hydroxytyrosol in radical scavenging assays as well as in cytotoxicity tests against tumour cells
Enantio- and Diastereoselective Synthesis of Highly Substituted Benzazepines by a Multicomponent Strategy Coupled with Organocatalytic and Enzymatic Procedures
No full textSintesi di pepdidomimetici ciclici contenenti sequenze RGD unite a scaffold di tipo azoninonico come potenziali inibitori delle integrine
No full textStudio della stereochimica dell’acido vanilmandelico mediante tecniche di cromatografia liquida accoppiata alla spettrometria di massa
No full textThioisomunchnones derivatives of mandelic acid and vanilmandelic acid : a serendipitous discovery with interesting applications
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Multicomponent reactions and organocatalysis: a suitable combination for stereoselective synthesis of highly substituted benzazepines
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