4,214 research outputs found
The Great Theatre of the World. Salvator Rosa and the Academies
No full textLa mostra organizzata con Dulwich Picture Gallery di Londra e Kimbell Art Museum di Fort Worth dall’autrice con Helen Langdon e Xavier Salomon, presenta un ingente numero di capolavori di Salvator Rosa. Nel catalogo la studiosa ha redatto numerose schede e un saggio sul rapporto fondamentale dell’artista con il mondo accademico –letterario, teatrale ed artistico- del suo tempo. Attraverso documenti per lo più inediti (componimenti, lettere, inventari), l’autrice ricostruisce un pezzo di vita culturale e artistica tra Firenze e Roma a cavallo del quinto e settimo decennio del Seicento. Si tratta di uno scenario in cui, insieme al protagonista Rosa, si intrecciano artisti del calibro di Pier Francesco Mola e Carlo Dolci, e committenti quali Flavio Chigi o Giovan Carlo de Medici. The exhibition, organized with the Dulwich Picture Gallery in London and the Kimbell Art Museum in Fort Worth by the author toghether with Helen Langdon and Xavier Salomon, had shown many of the Salvator Rosa’s masterpieces. In the catalogue the scholar did many entries and an essay on the really essential relation among the artist and the Seventeenth Century Academies of Florence and Rome. Academies that were not only artistic but also of music, theatre and poetry. Thanks to unpublished documents (poems, letters and inventories) the author can reconstruct the artistic and cultural life in Florence and Rome between 1640th and 1650th. Together with Salvator Rosa are others leading artists and patrons such as Pier Francesco Mola, Carlo Dolci, Pietro da Cortona, and Flavio Chigi or Giovan Carlo de Medici.
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Chondroitin sulfate. Structure, role and pharmacological activity. Nicola Volpi (Editor)
No full textContents
STRUCTURE Isolation, purification and analysis of chondroitin sulfate proteoglycans Fumiko Matsui and Atsuhiko Oohira Isolation and Purification of Chondroitin Sulfate Luiz-Claudio F. Silva Structure of chondroitin sulfate Fotini N. Lamari and Nikos K. Karamanos Progress in the structural biology of chondroitin sulfate Barbara Mulloy The biosynthesis and catabolism of galactosaminoglycans Vikas Prabhakar and Ram Sasisekharan Biosynthesis of chondroitin sulfate: from the early, precursor discoveries to nowadays, genetic approaches Mauro S.G. Pavao, Ana Christina Vilela-Silva and Paulo A.S. Mourao Advances in the analysis of chondroitin/dermatan sulfate M. Stylianou, I.-E. Triantaphyllidou and D.H. Vynios Chondroitin sulfate lyases - their applications in analysis and glycobiotechnology Emmanuel Petit, Cedric Delattre, Dulce Papy-Garcia and Phillipe Michaud Chondroitin sulfate Lyases: Structure, Activity and Applications in Analysis and the Treatment of Diseases Robert J. Linhardt, Fikri Y Avci, Toshohiko Toida, Yeong Shik Kim and Miroslaw Cygler BIOLOGICAL ROLE OF CHONDROITIN SULFATE Structure, metabolism and tissue roles of chondroitin sulfate proteoglycans Christopher J. Handley, Tom Samiric and Mina Z. Ilic Emergence and structural characteristics of chondroitin sulfates in the animal kingdom Lucia O. Sampaio and Helena B. Nader Role of the sulfation pattern of chondroitin sulfate in its biological activities and the binding of growth factors Chilkunda D. Nandini and Kazuyuki Sugahara Chondroitin sulfate as a key molecule in the development of atherosclerosis and cancer progression A.D. Theocharis, G.N. Tzanakakis and N.K. Karamanos Chondroitin sulfate proteoglycans in tumor progression Yanusz Wegrowski and Francois-Xavier Maquart Chondroitin sulfate proteoglycans in the brain Sachiko Aono and Atsuhiko Oohira Chondroitin/dermatan sulfate in the central nervous system: structures and functions in health and disease Uwe Rauch and Joachim Kappler Chondroitin sulfate proteoglycan and its degradation products in CNS repair Asya Rolls and Michal Schwartz Role of Chondroitin 4-Sulfate in Pregnancy-Associated Malaria D. Channe Gowda PHARMACOLOGICAL ACTIVITIES OF CHONDROITIN SULFATE Immunological activity of chondroitin sulfate Toshihiko Toida, Shinobu Sakai, Hiroshi Akiyama and Robert J. Lindhardt Antioxidant activity of chondroitin sulfate G.M. Campo, A. Avenoso, S. Campo, A.M. Ferlazzo and A. Caltroni Effects of chondroitin sulfate on the cellular metabolism N. Brandl, J. Holzmann, R. Schabus and M. Huettinger In vitro effects of chondroitin sulfate A. Fioravanti, R. Marcolongo and G. Collodel Effect of chondroitin sulfate as nutraceutical in dogs with arthropathies Britta Dobenecker Chondroitin sulfate as a structure modifying agent Daniel Uebelhart, Ruud Knols, Elling D. de Bruin and Gust Verbruggen CLINICAL EFFICACY AND TRIALS Chondroitin sulfate in the management of erosive osteoarthritis of the interphalangeal finger joints Gust Verbruggen Chondroitin sulfate in the management of hip and knee osteoarthritis: an overview Geraldine Bana, Benedicte Jamard, Evelyne Verrouil and Bernard Mazieres Treatment of knee osteoarthritis with oral chondroitin sulfate Daniel Uebelhart, Ruud Knols, Elling D. de Bruin and Gust Verbrugge
In ricordo di Franco Volpi
No full textIl testo ricorda il filosofo Franco Volpi, condirettore di "Ars interpretandi", scomparso nel 2009, ricostruendone il percorso intellettuale e le linee di ricerca orientate ai temi della razionalità pratica e delle modalità del comprendere e dell'interpretare
Analysis of flavonoids from propolis by on-line HPLC-electrospray mass spectrometry
No full textIn this paper, the qualitative and quantitative separation and determination of the polyphenolic component of propolis preparations in the form of ethanolic extract, usually used for commercial pharmaceutical preparations, has been investigated by means of on-line HPLC-ESI/MS technique. Propolis of different origin have been evaluated for their components and a specific fingerprint has been determined potentially useful for the quality control of extracts in pharmaceutical preparations. The ethanolic extracts of propolis from Argentina, Italy and Spain shows approximately the same total ion chromatogram (TIC) profile due to the presence of the same molecular species, identified by the negative ESI-MS. On the contrary, the samples from Azerbaijan, China, Ethiopia and Kenya show a very peculiar TIC profiles. By using many purified flavonoids and calibration curves over a wide concentration range, from 0.05 (5 mu g/ml) to 5 mu g (500 mu g/ml), an accurate assessment of the contents of several bioactive compounds in extract samples was performed. The propolis from Argentina, Italy and Spain show a great amount of pinocembrin (approximately 49%, 48% and 39% of the total identified flavonoids, respectively) and variable but similar percentages of the other species. On the contrary, the propolis from China, Azerbaijan and Ethiopia have a great amount of pinocembrin (approximately 63%, 46% and 62%, respectively) but no presence of genistein, kaempferol, apigenin and chrysin for the sample from China, genistein, kaempferol, acacetin and chrysin for the propolis from Azerbaijan, and no kaempferol and acacetin for the sample from Ethiopia. The ethanolic extract from propolis of Kenya has no identified flavonoid species but just a peak possessing a m/z of 253.0. Finally, an evaluation of the presence of total flavonoids for the various propolis samples was performed, with extracts from Argentina, Italy and Spain more rich in polyphenols than those from Azerbaijan, China, Ethiopia and Kenya. The HPLC-ESI/MS under the experimental conditions illustrated represents a valuable method for the qualitative and quantitative assay of the most relevant components of propolis. On-line HPLC-ESI/MS analysis constitutes an alternative to obtain typical fingerprints of propolis and a reliable identification of a large number of propolis polyphenolic components. (c) 2006 Elsevier B.V. All rights reserved
DYNAMICS CHANGES IN ENDOTHELIAL EXTRACELLULAR MATRIX INDUCED BY VERY LOW DENSITY LIPOPROTEIN
No full textPreviously we described the vascular extracellular matrix remodeling
induced by normal VLDL at physiological levels
1) Particularly, we described the differences in chondroitin sulfate/
dermatan sulfate proteoglycans (CS/DS-PGs) according to
the endothelial cell phenotypes. 2) The aim of the present study was to analyze the expression
pattern of CS/DS-PGs in the presence of increasing levels of
N-VLDL. Human N-VLDL were isolated by ultracentrifugation
from healthy volunteers. Human umbilical vein endothelial
cells (HlNEC) were obtained and cultured as described by Ulrich-
Merzenic.
3) Then, HlNEC were incubated with 0,75 and 100 mcg/mL of
lipoprotein for 24 h.
Protocols were approved by the Bioethics Committee of the University
of Buenos Aires, Argentina. After treatment, CS/DS-PGs
were characterized through:
1) PG core protein secretion, specifically decorin, biglycan, and
versican analysis by immunoblot;
2) glycosaminoglycans (GAGs) content studied by reverse phase
HPLC;
3) the levels of chondroitin N-acetylgalactosaminyltransferase-2
(ChGn-2) and chondroitin-4-0-sulfotransferase-1 (C4ST-1)
mRNA by RT-PCR.
A significant increase in the protein core of decorin and biglycan
was detected after treatment (0 vs 75 and 0 vs 100 mcg/mL
N-VLDL,p<0.05, n=3), whereas for versican the increase was only
observed at 75 mcg/mL (0 vs 75 mcg/mL N-VLDL,p<O.OOl,n=3).
A significant increase in CS and DS chains was detected at both
levels of N-VLDL (38.5±15.0; 388.0±20.0 and 82.5±50.0 ng/mL; 0,
75 and 100 mcg/mL N-VLDL,p<0.05, n=3), accompanied by an increase
in the sulfation ratio 4S/0S of CS and DS chains (4.88±0.13;
13.97±1.8; 14.53±11.46; 0, 75 y 100 mcg/mL, n=3). No differences
were observed in ChGn-2 and C4ST-1. At physiological levels,
VLDL induced a CS/DS-PG secretion pattern that may contribute
to the atheroprotective properties of this endothelial phenotype;
such characteristics were lost in the presence of higher levels of
the lipoprotein. Our results highlight the importance of CS/DS
PGs as a new target for atherosclerosis treatment,
Bibliografia
1. Oberkersch R, Rasente Y, Barakian B., Yuschak S., Volpi N., Calabrese
G. Extracellular matrix remodeling of endothelial cell was induced by
very low density lipoproteins through NFKB activation. 28° Congresso
Nazionale della Societa ltaliana per 10 Studio dell'Arteriosclerosi. Roma,
Italia. November 23·25, 2014. .
2. Oberkersch R, Rasente Y, Gualco L, Yuschak S, Calabrese G. Very low
density lipoproteins induce differential vascular extracellular remodeling
according to the endothelial phenotype. Angiogenesis and Leukocytes
Atherosclerosis. Geneve, Switzerland. January 30-31, 2014.
3. Ulrich-Merzenich G, Metzner C, Bhonde R, MaIsch G, Schiermeyer
B, Vetter H. Simultaneous isolation of endothelial and smooth muscle
cells from human umbilical artery or vein and their growth response to
low-density lipoproteins
Marisa Volpi. Legami a doppio filo fra pittura, scrittura, lettura
No full textIl contributo presenta la figura della critica e storica dell'arte Marisa Volpi (1928-2015), personalità di spicco della critica d'arte degli anni Sessanta e Settanta, nonché scrittrice (premio Viareggio 1986) e autrice di racconti ispirati alle vite d'artista. Con alcuni esempi, viene messo in luce lo stretto legame fra l'attività di ricerca storica, l'elaborazione critica e la scrittura di Marisa Volpi.The contribute focuses on the intellectual figure of Marisa Volpi (1928-2015): art historian, professor, art critic, curator and writer (Viareggio Prix 1986). The author of this contribute runs the website www.marisavolpi.it, with the patronage of the Department of Art History and Performing media at Sapienza University, where Marisa Volpi's archive is situated
Dalla punta della lingua, lo spirito : Il canto ikaro come mezzo di comunicazione interspecifica e come essere sonoro
No full textIn the Peruvian Amazon, the ability to exchange information
with non-human entities is considered a major way of accessing
knowledge. This essay examines the ikaro, a shamanic song used
for healing and for communicating with plants and spirits. Draw
ing on my experience with the Kichwa Runakuna, I suggest that
the music emitted through shamanic whistles and intonations is
not considered a mere immaterial element. On the contrary, the
sound of the ikaro represents a kind of incorporation of the healing
properties of plants. By assuming a tangible form through chant
ing, they can generate real effects in the world and influence the
subjects living there. The essay is divided into three sections. The
first one outlines the shamanic learning process, illustrating how
healers are encouraged from a young age to interact with medici
nal plants through preparations, dietary restrictions, and extended
isolations. The second presents the local ethnophysiology, show
ing that in the Amazon region all knowledge is expressed mainly
through the body. The third part focuses on the analysis of field
recorded ikaros: by focusing on the spiral progression of the texts
and the redundancy of the melodies, I will show how the native
healers try to give concreteness to these songs, while maintaining
their own agency. In a context where intentions and words belong
to the same material order as corporeality, it is not surprising that
music is considered as a “sonic being” that intentionally partici
pates in the everyday life of both humans and non-humans
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