2 research outputs found
Stochastic simulation algorithms for computational systems biology: Exact, approximate, and hybrid methods
No full textItaly 2Department of Computer Science, University of Pisa, Pisa, Italy Correspondence Luca Marchetti, The Microsoft Research— University of Trento Centre for Computational and Systems Biology (COSBI), Piazza Manifattura 1, 38068 Rovereto TN, Italy. Email: [email protected] | Corrado Priami1,2 | Luca Marchetti1 Abstract Nowadays, mathematical modeling is playing a key role in many different research fields. In the context of system biology, mathematical models and their associated computer simulations constitute essential tools of investigation. Among the others, they provide a way to systematically analyze systems perturbations, develop hypoth- eses to guide the design of new experimental tests, and ultimately assess the suitabil- ity of specific molecules as novel therapeutic targets. To these purposes, stochastic simulation algorithms (SSAs) have been introduced for numerically simulating the time evolution of a well-stirred chemically reacting system by taking proper account of the randomness inherent in such a system. In this work, we review the main SSAs that have been introduced in the context of exact, approximate, and hybrid stochastic simulation. Specifically, we will introduce the direct method (DM), the first reaction method (FRM), the next reaction method (NRM) and the rejection-based SSA (RSSA) in the area of exact stochastic simulation. We will then present the τ-leaping method and the chemical Langevin method in the area of approximate stochastic simulation and an implementation of the hybrid RSSA (HRSSA) in the context of hybrid stochastic-deterministic simulation. Finally, we will consider the model of the sphingolipid metabolism to provide an example of application of SSA to compu- tational system biology by exemplifying how different simulation strategies may unveil different insights into the investigated biological phenomenon
Use of analysis -based statements (CBCA) in criminal justice
No full textEl interés de este artículo es analizar a partir del estudio de los instrumentos legales y de un nuevo pensamiento procesal acerca de la importancia del uso del análisis de declaraciones basadas en criterios (CBCA), dando respuesta a la pregunta de si esta herramienta es el instrumento más idóneo para la evaluación de la veracidad de las declaraciones dentro del proceso penal en el entendido de que su uso sería más una técnica que una habilidad. Para lograr el objetivo, será necesario definir que existe la posibilidad de explorar los pasos que generan en avances y desarrollo en el Proceso Penal Acusatorio, dentro del cual el juicio oral es el escenario por excelencia donde la observancia de los principios probatorios de inmediación, concentración, publicidad y contradicción el Juez y las partes participan en la formación o práctica de la prueba testimonial, que requiere a su vez la aplicación de conocimientos teóricos – reglas de prueba y destrezas en la técnicas de oralidad; por lo que una vez constatada esta información se demostrará que sí es posible dar aplicación de esta técnica para generar mayor credibilidad en las declaraciones de los testigos.The interest of this paper is to analyze from a study of legal instruments and a new procedural thinking about the importance of using the analysis of statements based on criteria (CBCA), responding to the question of whether this tool is the instrument most suitable for the evaluation of the accuracy of statements in criminal proceedings on the understanding that their use would be more a technique than a skill. To achieve the goal, it is necessary to define what is possible to explore the steps that generate progress and development in the Adversarial Criminal Procedure, in which the trial is the setting par excellence where compliance with the evidentiary principles of immediacy, concentration, advertising and contradiction Judge and participant parties in training or practice of the testimony, which in turn requires the application of theoretical knowledge - rules of evidence and skills in oral techniques; so once observed this information will demonstrate that it is possible to apply this technique to generate greater credibility in the statements of witnesses
